Superfund Research Program

Mechanisms and Impacts of PCB Resistant Fish

Project Leader: Mark E. Hahn (Woods Hole Oceanographic Institution)
Co-Investigators: Sibel I. Karchner (Woods Hole Oceanographic Institution), Neelakanteswar Aluru (Woods Hole Oceanographic Institution)
Grant Number: P42ES007381
Funding Period: 1995-2021

Project-Specific Links

Publications

2024

• Miller JT, Clark BW, Reid NM, Karchner SI, Roach J, Hahn ME, Nacci DE, Whitehead A. 2024. Independently evolved pollution resistance in four killifish populations is largely explained by few variants of large effect. Evol Appl 17(1):doi:10.1111/eva.13648 PMID:38293268 PMCID:10824703

2022

• Zhang W, Xie HQ, Li Y, Zhou M, Zhou Z, Wang R, Hahn ME, Zhao B. 2022. The aryl hydrocarbon receptor: A predominant mediator for the toxicity of emerging dioxin-like compounds. J Hazard Mater 426:doi:10.1016/j.jhazmat.2021.128084 PMID:34952507

2021

• Bozinovic G, Shea D, Feng Z, Hinton DE, Sit TL, Oleksiak MF. 2021. PAH-pollution effects on sensitive and resistant embryos: Integrating structure and function with gene expression. PLoS One 16(4):e0249432. doi:10.1371/journal.pone.0249432 PMID:33822796 PMCID:PMC8023486

2020

• Aranguren-Abadia L, Lille-Langoy R, Madsen AK, Karchner SI, Franks DG, Yadetie F, Hahn ME, Goksoyr A, Karlsen OA. 2020. Molecular and Functional Properties of the Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a. Environ Sci Technol 54,2:1033-1044. doi:10.1021/acs.est.9b05312 PMID:31852180 PMCID:PMC7003535
• Avilla MN, Malecki K, Hahn ME, Wilson RH, Bradfield CA. 2020. The ah receptor: adaptive metabolism, ligand diversity, and the xenokine model. Chem Res Toxicol 33:860-879. doi:10.1021/acs.chemrestox.9b00476 PMID:32259433 PMCID:PMC7175458
• Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Hahn ME, Nacci DE, Schlezinger JJ. 2020. Tributyltin disrupts fin development in Fundulus heteroclitus from both PCB-sensitive and resistant populations: Investigations of potential interactions between AHR and PPARy. Aquat Toxicol 218:105334. doi:10.1016/j.aquatox.2019.105334 PMID:31743820 PMCID:PMC6935467
• Hahn ME, Sadler K. 2020. Casting a Wide Net: Use of Diverse Model Organisms to Advance Toxicology. Dis Model Mech 13:4. doi:10.1242/dmm.043844 PMID:32094287 PMCID:PMC7132827
• Kazzaz SA, Tagliabue SG, Franks DG, Denison MS, Hahn ME, Bonati L, Powell WH. 2020. An aryl hydrocarbon receptor from the caecilian Gymnopis multiplicata suggests low dioxin affinity in the ancestor of all three amphibian orders. Gen Comp Endocrinol 299(10):doi:10.1016/j.ygcen.2020.113592 PMID:32858041 PMCID:PMC7771225
• Shankar P, Dasgupta S, Hahn ME, Tanguay RL. 2020. A review of the functional roles of the zebrafish aryl hydrocarbon receptors. Toxicol Sci 178:215-238. doi:10.1093/toxsci/kfaa143 PMID:32976604 PMCID:PMC7706399

2019

• Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Claus Henn B, Griffith KN, Howes BL, Schlezinger DR, Hahn ME, Nacci DE, Schlezinger JJ. 2019. Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A. Aquat Toxicol 210:30-43. doi:10.1016/j.aquatox.2019.02.011 PMID:30822701 PMCID:PMC6544361
• McDonough CA, Franks DG, Hahn ME, Lohmann R. 2019. Aryl hydrocarbon receptor-mediated activity of gas-phase ambient air derived from passive sampling and an in vitro bioassay. Environ Toxicol Chem 38(4):748-759. doi:10.1002/etc.4361 PMID:30648756 PMCID:PMC6467651
• Zhang W, Xie HQ, Li Y, Jin T, Li J, Xu L, Zhou Z, Zhang S, Ma D, Hahn ME, Zhao B. 2019. Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure. Sci Total Environ 669:621-630. doi:10.1016/j.scitotenv.2019.02.440 PMID:30893621 PMCID:PMC6581032
• Zhang W, Xie HQ, Li Y, Zou X, Xu L, Ma D, Li J, Ma Y, Jin T, Hahn ME, Zhao B. 2019. Characterization of the aryl hydrocarbon receptor (AhR) pathway in anabas testudineus and mechanistic exploration of the reduced sensitivity of AhR2a. Environ Sci Technol 53:12803-12811. doi:10.1021/acs.est.9b04181 PMID:31566365 PMCID:PMC6832778

2018

• Glazer L, Kido Soule MC, Longnecker K, Kujawinski EB, Aluru N. 2018. Hepatic metabolite profiling of polychlorinated biphenyl (PCB)-resistant and sensitive populations of Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol 205:114-122. doi:10.1016/j.aquatox.2018.10.007 PMID:30368057 PMCID:PMC6246827
• Hahn ME. 2018. Evolutionary concepts can benefit both fundamental research and applied research in toxicology (A comment on Brady et al. 2017). Evol Appl 12:350-352. doi:10.1111/eva.12695 PMID:30697345 PMCID:PMC6346646
• Lemaire B, Karchner SI, Goldstone JV, Lamb DC, Drazen JC, Rees F, Hahn ME, Stegeman JJ. 2018. Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochim Biophys Acta 1866:155-165. doi:10.1016/j.bbapap.2017.06.026 PMID:28694077 PMCID:PMC5693637

2017

• Hahn ME, Karchner SI, Merson RR. 2017. Diversity as opportunity: insights from 600 Million years of AHR evolution. Curr Opin Toxicol 2:58-71. doi:10.1016/j.cotox.2017.02.003 PMID:28286876 PMCID:PMC5343764
• Holland EB, Goldstone JV, Pessah IN, Whitehead A, Reid NM, Karchner SI, Hahn ME, Nacci DE, Clark BW, Stegeman JJ. 2017. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): a phylogenetic and population-based comparison. Aquat Toxicol 192:105-115. doi:10.1016/j.aquatox.2017.09.002 PMID:28942070 PMCID:PMC5662517
• Reid NM, Jackson CE, Gilbert D, Minx P, Montague MJ, Hampton TH, Helfrich LW, King BL, Nacci DE, Aluru N, Karchner SI, Colbourne JK, Hahn ME, Shaw JR, Oleksiak MF, Crawford DL, Warren WC, Whitehead A. 2017. The landscape of extreme genomic variation in the highly adaptable Atlantic killifish. Genome Biol Evol 9:659-676. doi:10.1093/gbe/evx023 PMID:28201664 PMCID:PMC5381573
• Sant KE, Hansen JM, Williams LM, Tran NL, Goldstone JV, Stegeman JJ, Hahn ME, Timme-Laragy AR. 2017. The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biol 13:207-218. doi:10.1016/j.redox.2017.05.023 PMID:28582729 PMCID:PMC5458767
• Timme-Laragy AR, Hahn ME, Hansen JM, Rastogi A, Roy MA. 2017. Redox stress and signaling during vertebrate embryonic development: regulation and responses. Semin Cell Dev Biol 80:17-28. doi:10.1016/j.semcdb.2017.09.019 PMID:28927759 PMCID:PMC5650060
• Wang Z, Monti S, Sherr DH. 2017. The diverse and important contributions of the AHR to cancer and cancer immunity. Curr Opin Toxicol 2:93-102. doi:10.1016/j.cotox.2017.01.008 (in press)
• Whitehead A, Clark BW, Reid NM, Hahn ME, Nacci DE. 2017. When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations. Evol Appl 10:762-783. doi:10.1111/eva.12470 PMID:29151869 PMCID:PMC5680427

2016

• Nacci DE, Hahn ME, Karchner SI, Jayaraman S, Mostello C, Miller KM, Blackwell CG, Nisbet IC. 2016. Integrating monitoring and genetic methods to infer historical risks of PCBs and DDE to common and roseate terns nesting near the New Bedford Harbor Superfund site (Massachusetts, USA). Environ Sci Technol 50(18):10226-10235. doi:10.1021/acs.est.6b02108 PMID:27564328 PMCID:PMC5110212
• Parente T, Moreira DA, Magalhaes M, Andrade PC, Furtado C, Haas B, Stegeman JJ, Hahn ME. 2016. The liver transcriptome of suckermouth armoured catfish (Pterygoplichthys anisitsi, Loricariidae): Identification of expansions in defensome gene families. Mar Pollut Bull 115:352-361. PMID:28062095 PMCID:PMC5310677
• Reid N, Proestou DA, Clark BW, Warren WC, Colbourne JK, Shaw JR, Karchner SI, Hahn ME, Nacci DE, Oleksiak MF, Crawford DL, Whitehead A. 2016. The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. Science 354(6317):1305-1308. doi:10.1126/science.aah4993 PMID:27940876 PMCID:PMC5206662
• Townley IK, Karchner SI, Skripnikova E, Wiese T, Hahn ME, Rees BB. 2016. Sequence and functional characterization of hypoxia inducible factors, HIF1α, HIF2αa, and HIF3α, from the estuarine fish, Fundulus heteroclitus. Am J Physiol Regul Integr Comp Physiol 312(3):R412-R425. doi:10.1152/ajpregu.00402.2016 PMID:28039194 PMCID:PMC5402000
• Wincent E, Kubota A, Timme-Laragy A, Jonsson ME, Hahn ME, Stegeman JJ. 2016. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol 110-111:117-129. doi:10.1016/j.bcp.2016.04.012 PMID:27112072 PMCID:PMC4887394

2015

• Aluru N, Karchner SI, Franks DG, Champlin D, Hahn ME. 2015. Targeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol 158:192-201. doi:10.1016/j.aquatox.2014.11.016 PMID:25481785 PMCID:PMC4272816
• DeGroot DE, Franks DG, Higa T, Tanaka J, Hahn ME, Denison MS. 2015. Naturally occurring marine brominated indoles are aryl hydrocarbon receptor ligands/agonists. Chem Res Toxicol 28(6):1176-1185. doi:10.1021/acs.chemrestox.5b00003 PMID:26001051 PMCID:PMC4469569
• Grans J, Wassmur B, Fernandez-Santoscoy M, Zanette J, Woodin BR, Karchner SI, Nacci DE, Champlin D, Jayaraman S, Hahn ME, Stegeman JJ, Celander MC. 2015. Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor. Aquat Toxicol 159:198-207. doi:10.1016/j.aquatox.2014.12.010 PMID:25553538 PMCID:PMC4311260

2014

• Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger JJ, Sherr DH, Silverstone AE, Hahn ME, McCune JM. 2014. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 9(2):15. doi:10.1371/journal.pone.0087877 PMID:24498387 PMCID:PMC3912126
• Parks A, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. 2014. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol 86(5):593-608. doi:10.1124/mol.114.093369 PMID:25159092 PMCID:PMC4201140
• Reitzel AM, Karchner SI, Franks DG, Evans BR, Nacci DE, Champlin D, Vieira VM, Hahn ME. 2014. Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. BMC Evol Biol 14:6. doi:10.1186/1471-2148-14-6 PMID:24422594 PMCID:PMC3899389

2013

• Harbeitner RC, Hahn ME, Timme-Laragy AR. 2013. Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus). Ecotoxicology 22:387-401. doi:10.1007/s10646-012-1033-x PMID:23329125 PMCID:PMC3573531
• Timme-Laragy AR, Goldstone JV, Imhoff BR, Stegeman JJ, Hahn ME, Hansen JM. 2013. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free Radic Biol Med 65:89-101. doi:10.1016/j.freeradbiomed.2013.06.011 PMID:23770340 PMCID:PMC3823629

2011

• Hahn ME. 2011. Mechanistic research in aquatic toxicology: perspectives and future directions. Aquat Toxicol 105:67-71. doi:10.1016/j.aquatox.2011.06.001 PMID:22099346 PMCID:PMC3220193
• Oleksiak MF, Karchner SI, Jenny MJ, Franks DG, Mark Welch DB, Hahn ME. 2011. Transcriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund site. BMC Genomics 12:263. doi:10.1186/1471-2164-12-263 PMID:21609454 PMCID:PMC3213123
• Whitehead A, Galvez F, Zhang S, Williams LM, Oleksiak MF. 2011. Functional genomics of physiological plasticity and local adaptation in Killifish. J Hered 102:499-511. doi:10.1093/jhered/esq077 PMID:20581107 PMCID:PMC3156563

2010

• Aluru N, Karchner SI, Hahn ME. 2010. Role of DNA methylation of AHR1 and AHR2 promoters in differential sensitivity to PCBs in Atlantic Killifish, Fundulus heteroclitus. Aquat Toxicol 101:288-94. doi:10.1016/j.aquatox.2010.10.010 PMID:21111492 PMCID:PMC3019765
• Howard G, Schlezinger JJ, Hahn ME, Webster TF. 2010. Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists. Environ Health Perspect 118(5):666-672. doi:10.1289/ehp.0901312 PMID:20435555 PMCID:PMC2866683

2009

• Hahn ME, Allan LL, Sherr DH. 2009. Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor. Biochem Pharmacol 77(4):485-497. doi:10.1016/j.bcp.2008.09.016 PMID:18848529 PMCID:PMC2701375
• Karchner SI, Jenny MJ, Tarrant AM, Evans BR, Kang HJ, Bae I, Sherr DH, Hahn ME. 2009. The active form of human aryl hydrocarbon receptor (AHR) repressor lacks exon 8, and its Pro 185 and Ala 185 variants repress both AHR and hypoxia-inducible factor. Mol Cell Biol 29(13):3465-3477. doi:10.1128/MCB.00206-09 PMID:19380484 PMCID:PMC2698758

2008

• Evans BR, Karchner SI, Allan LL, Pollenz RS, Tanguay RL, Jenny MJ, Sherr DH, Hahn ME. 2008. Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. Mol Pharmacol 73(2):387-98. PMID:18000031
• Hansson MC, Hahn ME. 2008. Functional properties of the four Atlantic salmon (Salmo salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms. Aquat Toxicol 86(2):121-30. PMID:18063141
• Oleksiak MF. 2008. Changes in gene expression due to chronic exposure to environmental pollutants. Aquat Toxicol 90(3):161-171. doi:10.1016/j.aquatox.2008.08.010 PMID:18929415 PMCID:PMC2584160
• Oleksiak MF. 2008. Toxicogenomics. Chapter 2 in: Molecular and Biochemical Toxicology, 4th Edition. Wiley, pp.25-39.
• Whalen KE, Morin D, Lin C, Tjeerdema RS, Goldstone JV, Hahn ME. 2008. Proteomic identification, cDNA cloning and enzymatic activity of glutathione S-transferases from the generalist marine gastropod, Cyphoma gibbosum. Arch Biochem Biophys 478(1):7-17. doi:10.1016/j.abb.2008.07.007 PMID:18671936

2007

• Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Rees BB, Singer TD, Stegeman JJ, Towle DW, van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL, Oleksiak MF. 2007. Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comp Biochem Physiol Part D Genomics Proteomics 2(4):257-286. doi:10.1016/j.cbd.2007.09.001 PMID:18071578 PMCID:PMC2128618
• Carvan MJ, Gallagher EP, Goksoyr A, Hahn ME, Joakim DG. 2007. Fish models in toxicology. Zebrafish 4(1):9-20. doi:10.1089/zeb.2006.9998 PMID:18041939
• Hahn ME, Hestermann EV. 2007. Receptor-mediated mechanisms of toxicity. Chapter 5 in: The Toxicology of Fishes. Taylor & Francis, Boca Raton, FL. pp.235-272.
• Jonsson ME, Jenny MJ, Woodin BR, Hahn ME, Stegeman JJ. 2007. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 100(1):180-93. PMID:17686920
• Reddy CM, Stegeman JJ, Hahn ME. 2007. Organic Pollutants: Presence and Effects in Humans and Marine Animals. Chapter 7 in: Oceans and Human Health: Risks and Remedies from the Seas. pp.121-144.

2006

• Hahn ME, Karchner SI, Evans BR, Franks DG, Merson RR, Lapseritis JM. 2006. Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomic. J Exp Zool 305(9):693-706. PMID:16902966
• Merson RR, Franks DG, Karchner SI, Hahn ME. 2006. Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitus. Comp Biochem Physiol C Toxicol Pharmacol 142(1-2):85-94. doi:10.1016/j.cbpc.2005.10.013 PMID:16364694
• Tarrant AM, Greytak SR, Callard GV, Hahn ME. 2006. Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness. J Mol Endocrinol 37(1):105-20. PMID:16901928

2005

• Evans BR, Karchner SI, Franks DG, Hahn ME. 2005. Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo. Arch Biochem Biophys 441(2):151-167. doi:10.1016/j.abb.2005.07.008 PMID:16122694
• Timme-Laragy AR, Meyer JN, Waterland RA, Di Giulio RT. 2005. Analysis of CpG methylation in the killifish CYP1A promoter. Comp Biochem Physiol C Toxicol Pharmacol 141(4):406-411. PMID:16257583
• Yang X, Liu D, Murray TJ, Mitchell GC, Hesterman EV, Karchner SI, Merson RR, Hahn ME, Sherr DH. 2005. The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells. Oncogene 24(53):7869-7881. doi:10.1038/sj.onc.1208938 PMID:16091746

2004

• Hahn ME, Karchner SI, Franks DG, Merson RR. 2004. Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus). Pharmacogenet Genomics 14(2):131-143. PMID:15077014
• Powell WH, Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ, Hahn ME. 2004. Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus). Mar Environ Res 58(2-5):119-124. PMID:15178023

2003

• Meyer JN, Wassenberg DM, Karchner SI, Hahn ME, Di Giulio RT. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environ Toxicol Chem 22(10):2337-2343. PMID:14551997

2002

• Bard SM, Bello SM, Hahn ME, Stegeman JJ. 2002. Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics. Aquat Toxicol 59(3-4):237-251. PMID:12127740
• Karchner SI, Franks DG, Powell WH, Hahn ME. 2002. Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. J Biol Chem 277(9):6949-6959. doi:10.1074/jbc.M110779200 PMID:11742002
• Powell WH, Hahn ME. 2002. Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants. J Exp Zool 294(1):17-29. PMID:11932946

2001

• Bello SM, Franks DG, Stegeman JJ, Hahn ME. 2001. Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes. Toxicol Sci 60(1):77-91. PMID:11222875
• Hahn ME. 2001. Dioxin toxicology and the aryl hydrocarbon receptor: insights from fish and other non-traditional models. Mar Biotechnol (NY) 3:S224-S238. PMID:14961319
• Toomey BH, Bello SM, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Giulio RT. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquat Toxicol 53(2):127-138. PMID:11311389

2000

• Karchner SI, Kennedy SW, Trudeau S, Hahn ME. 2000. Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian. Mar Environ Res 50(1-5):51-56. PMID:11460741
• Oleksiak MF, Wu S, Parker C, Zeldin DC. 2000. Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns. J Biol Chem 275(4):2312-2321. PMID:10644680
• Powell WH, Bright R, Bello SM, Hahn ME. 2000. Developmental and tissue-specific expression of AHR1, AHR2, and ARNT2 in dioxin-sensitive and -resistant populations of the marine fish, Fundulus heteroclitus. Toxicol Sci 57(2):229-239. PMID:11006353
• Powell WH, Hahn ME. 2000. The evolution of aryl hydrocarbon signaling proteins: diversity of ARNT isoforms among fish species. Mar Environ Res 50(1-5):39-44. PMID:11460724
• Quadri SA, Qadri AN, Hahn ME, Mann KK, Sherr DH. 2000. The bioflavonoid galangin blocks aryl hydrocarbon receptor (AhR) activation and polycyclic aromatic hydrocarbon-induced Pre-B cell apoptosis. Mol Pharmacol 58:515-525. PMID:10953044
• Toomey BH, Bello SM, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Giulio RT. 2000. TCDD induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquat Toxicol

1999

• Bello SM. 1999. Characterization of resistance to halogenated aromatic hydrocarbons in a population of Fundulus heteroclitus from a marine Superfund site. Ph.D. Thesis, Woods Hole Oceanographic Institution / Massachusetts Institute of Technology.
• Black VH, Shaw PM, Karchner SI, Powell WH, Hahn ME. 1999. Differential expression of CYP1A1 and CYP1A2, but not AHR or ARNT, in guinea pig adrenal and liver. Endocr Res 24:631-632.
• Elskus AA, Monosson E, McElroy AE, Stegeman JJ, Woltering DS. 1999. Altered CYP1A expression in Fundulus heteroclitus adults and larvae: a sign of pollutant resistance?. Aquat Toxicol 45(2-3):99-113.
• Karchner SI, Powell WH, Hahn ME. 1999. Structural and functional characterization of two highly divergent aryl hydrocarbon receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus. Evidence for a novel class of ligand-binding basic helix-loop-helix Per-ARNT-Sim (bHLH-PAS) factors. J Biol Chem 274:33814-33824.
• Mann KK, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of DMBA metabolites in preB cell apoptosis. Toxicol Sci 48(1-S):
• Mann KK, Matulka RA, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenzanthracene-induced pre-B cell apoptosis. Toxicol Appl Pharmacol 161:10-22.
• Powell WH, Karchner SI, Bright R, Hahn ME. 1999. Functional diversity of vertebrate ARNT proteins: identification of ARNT2 as the predominant form of ARNT in the marine teleost, Fundulus heteroclitus. Arch Biochem Biophys 361(1):156-163. doi:10.1006/abbi.1998.0992 PMID:9882441

1998

• Bello SM, Franks DG, Stegeman JJ, Hahn ME. 1998. Dioxin Resistance in Killifish (Fundulus heteroclitus) from the New Bedford Harbor Superfund Site: In Vivo and In Vitro studies of CYP1A1 Inducibility. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19^th Annual Meeting. Charlotte, NC. pp.168.
• Hahn ME. 1998. Mechanisms of innate and acquired resistance to dioxin-like compounds. Reviews in Toxicology 2:395-443.
• Hahn ME. 1998. The aryl hydrocarbon receptor: a comparative perspective. Comp Biochem Physiol 121(1-3):23-53. PMID:9972449
• Hahn ME, Karchner SI, Shapiro MA, Perera SA. 1998. The aryl hydrocarbon receptor in early vertebrates. Mar Environ Res 46(1-5):41-44.
• Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ. 1998. Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1A genes: Update with new sequences. Comp Biochem Physiol 121C:231-240. PMID:9972465
• Powell WH, Karchner SI, Hahn ME. 1998. Aryl Hydrocarbon Signaling Components in Fundulus heteroclitus: A Phylogenetic Perspective. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19^th Annual Meeting. Charlotte, NC.
• Schlezinger JJ, Parker C, Zeldin DC, Stegeman JJ. 1998. Arachidonic acid metabolism in the marine fish Stenotomus chrysops (scup) and the effects of cytochrome P4501A inducers. Arch Biochem Biophys 353(2):265-275. PMID:9606961
• Schlezinger JJ, Struntz WD, Stegeman JJ. 1998. Cytochrome P4501A (CYP1A) and planar halogenated hydrocarbons (pHAH): Oxidative inactivation and reactive oxygen production. In: Proceedings of the 37^th Society of Toxicology Annual Meeting, March 1-5. Seattle, WA.
• Yawetz A, Woodin BR, Stegeman JJ. 1998. Cytochromes P450 (CYP) in liver of the turtle, Chrysemes picta picta and the induction and partial purification of CYP1A-like proteins. Biochim Biophys Acta 1381(1):12-26. PMID:9659368

1997

• Bello SM, Stegeman JJ, Hahn ME. 1997. Lack of cytochrome P450-1A inducibility in Fundulus heteroclitus from New Bedford Harbor: A case of dioxin resistance?. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
• Hahn ME, Karchner SI, Perera SA, Shapiro MA. 1997. Evolution of the Ah receptor: evidence for two AhR genes in early vertebrates. Environ Health Perspect 36:242.
• Hahn ME, Karchner SI, Shapiro MA, Perera SA. 1997. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family. Proc Natl Acad Sci U S A 94(25):13743-13748. PMID:9391097 PMCID:PMC28377
• Karchner SI, Hahn ME. 1997. Molecular Characterization of Two Aryl Hydrocarbon (Ah) Receptors in the Mummichog Fundulus heteroclitus. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA. pp.426.
• Schlezinger JJ, White RD, Stegeman JJ. 1997. Inactivation of cytochrome P4501A1 by 3,3',4,4'-tetrachlorobiphenyl and the formation of reactive oxygen species. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.

1996

• Hahn ME, Karchner SI, Perera SA. 1996. Molecular studies on the Ah receptor (AhR) in early vertebrates (bony and cartilaginous fish) and evidence for a second vertebrate AhR gene. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.232.
• Schlezinger JJ, White RD, Stegeman JJ. 1996. 3,3',4,4'-tetrachlorobiphenyl stimulates release of active oxygen from hepatic microsomes and the oxidative inactivation of cytochrome P4501A1. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.192.