Title: Methylation data of pediatric B-cell acute leukemias

Accession Number: GSE56600

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE56600

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Methylation profiling by genome tiling array

Organism(s): Homo sapiens

Summary: We investigated DNA methylomes of 227 pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. The current study identified a link between DNA methylome of B-cell acute lymphoblastic leukemias (B-ALLs) and embryonic stem cell (ESC) bivalency, through which tumor cells can mimic the pluripotency of ESCs.

Publication(s) associated with this dataset:

• Lee S, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith AJ, Martin-Subero JI, Heath S, Houseman EA, Roy R, Wrensch MR, Wiencke JK, Metayer C, Wiemels JL. 2015. Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. Nucleic Acids Res 43(5):2590-2602. doi:10.1093/nar/gkv103 PMID:25690899 PMCID:PMC4357708