Superfund Research Program
Nutrition and Superfund Chemical Toxicity
Center Director: Kelly G. Pennell
Grant Number: P42ES007380
Funding Period: 1997-2025
Program Links
Title: 16S rDNA sequencing data of Ldlr-/- mouse gut microbiomes
Accession Number: E-MTAB-8798
Link to Dataset: https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-8798
Repository: ArrayExpress
Data Type(s): Gene Expression
Experiment Type(s): DNA-seq
Organism(s): Mus musculus
Summary: We have previously demonstrated that the gut microbiota can play a role in the pathogenesis of conditions associated with exposure to environmental pollutants. It is well accepted that diets high in fermentable fibers such as inulin can beneficially modulate the gut microbiota and lessen the severity of pro-inflammatory diseases. Therefore, we aimed to test the hypothesis that hyperlipidemic mice fed a diet enriched with inulin would be protected from the pro-inflammatory toxic effects of PCB 126.