Superfund Research Program
Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)
Center Director: Akram N. Alshawabkeh
Grant Number: P42ES017198
Funding Period: 2010-2025
Program Links
Title: Expression data from fetal membranes
Accession Number: GSE96557
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE96557
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Expression profiling by array
Organism(s): Homo sapiens
Summary: Genome wide expression profiling was used to identify signifnificantly changed genes in fetal membranes after GBS treatment. Genome-wide expression profiles in GBS-inoculated human extraplacental membranes in vitro were used to identify transcriptomic pathways altered by GBS . Using bioinformatics analysis of these expression profiles we aimed to test our hypothesis that GBS activates pathways related to inflammation and premature birth in human extraplacental membranes.
Publication(s) associated with this dataset:- Park H, Harris SM, Boldenow E, McEachin RC, Sartor MA, Chames MC, Loch-Caruso R. 2017. Group B streptococcus activates transcriptomic pathways related to premature birth in human extraplacental membranes in vitro. Biol Reprod 98(3):396-407. doi:10.1093/biolre/iox147 PMID:29155939 PMCID:PMC6248496