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Person Details: Alan R. Buckpitt

Superfund Research Program

Alan R. Buckpitt

University of California-Davis
School of Veterinary Medicine
Department of Molecular Biosciences
220 Everson Hall
Davis, California 95616
Phone: 530-752-7674
Fax: 530-752-4698


Research Briefs





  • Schebb N, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH. 2014. Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Dispos 42(7):1098-1102. doi:10.1124/dmd.114.058206 PMID:24733789 PMCID:PMC4170114




  • Morisseau C, Newman JW, Wheelock CE, Hill T, Morin D, Buckpitt AR, Hammock BD. 2008. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chem Res Toxicol 21(4):951-957. doi:10.1021/tx700446u PMID:18363382


  • Lin C, Boland BC, Lee YJ, Salemi MR, Morin D, Miller LA, Plopper CG, Buckpitt AR. 2006. Identification of proteins adducted by reactive metabolites of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques. Proteomics 6(3):972-982. PMID:16453347
  • Wheelock AM, Morin D, Bartosiewicz MJ, Buckpitt AR. 2006. Use of a fluorescent internal protein standard to achieve quantitative two-dimensional gel electrophoresis. Proteomics 6(5):1385-1398. PMID:16429456


  • Baldwin RM, Shultz MA, Buckpitt AR. 2005. Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4. J Pharmacol Exp Ther 312(2):857-865. PMID:15509722
  • Isbell MA, Morin D, Boland BC, Buckpitt AR, Salemi MR, Presley JM. 2005. Identification of proteins adducted by reactive naphthalene metabolites in vitro. Proteomics 5(16):4197-4204. PMID:16206326
  • Lee MG, Phimister AJ, Morin D, Buckpitt AR, Plopper CG. 2005. In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation. J Pharmacol Exp Ther 314(1):103-110. PMID:15833892
  • Lin C, Isbell MA, Morin D, Boland BC, Salemi MR, Jewell WT, Weir AJ, Fanucchi MV, Baker GL, Plopper CG, Buckpitt AR. 2005. Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs. lung rway incubation in situ vs. lung microsomes. Chem Res Toxicol 18(5):802-813.
  • Phimister AJ, Nagasawa HT, Buckpitt AR, Plopper CG. 2005. Prevention of naphthalene-induced pulmonary toxicity by glutathione prodrugs: roles for glutathione depletion in adduct formation and cell injury. J Biochem Mol Toxicol 19(1):42-51. PMID:15736154
  • Wheelock AM, Boland BC, Isbell MA, Morin D, Wegesser TC, Plopper CG, Buckpitt AR. 2005. In Vivo effects of ozone exposure on protein adduct formation by 1-nitronaphthalene rat lung. Am J Respir Crit Care Med 33(2):130-137. PMID:15845863
  • Wheelock AM, Buckpitt AR. 2005. Software-induced variance in two-dimensional gel electrophoresis image analysis. Electrophoresis 26:4508-4520. PMID:16315176


  • Boland BC, Lin C, Morin D, Miller LA, Plopper CG, Buckpitt AR. 2004. Site specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of Rhesus macaques. J Pharmacol Exp Ther 310(2):546-554. PMID:15082753
  • Phimister AJ, Lee MG, Morin D, Buckpitt AR, Plopper CG. 2004. Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice. Toxicol Sci 82(1):268-278. PMID:15319489
  • Shultz MA, Zhang L, Gu Y, Baker GL, Fanucchi MV, Padua AM, Gurske WA, Morin D, Penn SG, Jovanovich SB, Plopper CG, Buckpitt AR. 2004. Gene expression analysis in response to lung toxicants: I Sequencing and microarray development. Am J Respir Cell Mol Biol 30(3):296-310. doi:10.1165/rcmb.2003-0214OC PMID:12947022
  • Wheelock AM, Zhang L, Tran M, Morin D, Penn SG, Buckpitt AR, Plopper CG. 2004. Isolation of rodent airway epithelial cell proteins facilitates in vivo proteomics studies of lung toxicity. Am J Physiol 286(2):L399-L410. doi:10.1152/ajplung.00072.2003 PMID:14594729


  • Buckpitt AR, Boland BC, Isbell MA, Morin D, Shultz MA, Baldwin RM, Chan K, Karlsson A, Lin C, Taff A, West JA, Fanucchi MV, Van Winkle LS, Plopper CG. 2002. Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity. J Mol Biol 34(4):791-820. PMID:12487150
  • Pakehham G, Lango J, Buonarati M, Morin D, Buckpitt AR. 2002. Urinary naphthalene mercapturates as biomarkers of exposure and stereoselectivity of naphthalene epoxidation. Drug Metab Dispos 30(3):247-253. PMID:11854141
  • West JA, Williams KJ, Toskala E, Nishio SJ, Fleschner CA, Forman HJ, Buckpitt AR, Plopper CG. 2002. Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the glutathione pool. Am J Pathol 160(3):1115-1127. PMID:11891208


  • Bartosiewicz MJ, Jenkins D, Penn SG, Emery J, Buckpitt AR. 2001. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. J Pharmacol Exp Ther 297(3):895-905. PMID:11356909
  • Bartosiewicz MJ, Penn SG, Buckpitt AR. 2001. Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene. Environ Health Perspect 109(1):71-74. PMID:11171528
  • Plopper CG, Van Winkle LS, Fanucchi MV, Malburg SR, Nishio SJ, Chang A, Buckpitt AR. 2001. Early events in naphthalene-induced acute Clara cell toxicity - II. Comparison of glutathione depletion and histopathology by airway location. Am J Respir Cell Mol Biol 24(3):272-281. PMID:11245626
  • Shultz MA, Morin D, Chang A, Buckpitt AR. 2001. Metabolic capabilities of CYP2F2 with various pulmonary toxicants and its relative abundance in mouse lung subcompartments. J Pharmacol Exp Ther 296(2):510-519. PMID:11160638
  • West JA, Pakehham G, Morin D, Fleschner CA, Plopper CG, Buckpitt AR. 2001. Inhaled naphthalene causes dose dependent Clara cell toxicity in mice but not in rats. Toxicol Appl Pharmacol 173(2):114-119. PMID:11384213


  • Bartosiewicz MJ, Trounstine M, Barker D, Johnston R, Buckpitt AR. 2000. Development of a toxicological gene array and quantitative assessment of this technology. Arch Biochem Biophys 376(1):66-73. PMID:10729191
  • Fanucchi MV, Buckpitt AR, Murphy M, Storms DH, Hammock BD, Plopper CG. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicol Appl Pharmacol 168(3):253-267. PMID:11042098
  • Lakritz J, Winder BS, Noorouz-Zadeh J, Huang TL, Buckpitt AR, Hammock BD, Plopper CG. 2000. Hepatic and pulmonary enzyme activities in horses. American Journal of Veterinary Research 61(2):152-157. PMID:10685686
  • Watt KC, Buckpitt AR. 2000. Species differences in the regio- and stereo-selectivity of 1-nitronaphthalene metabolism. Drug Metab Dispos 28(4):376-378.
  • West JA, Buckpitt AR, Plopper CG. 2000. Elevated airway GSH resynthesis confers protection to Clara cells from naphthalene injury in mice made tolerant by repeated exposures. J Pharmacol Exp Ther 294(2):516-523. PMID:10900227
  • West JA, Chichester C, Buckpitt AR, Tyler NK, Brennan P, Helton C, Plopper CG. 2000. Heterogeneity of Clara cell glutathione - A possible basis for differences in cellular responses to pulmonary cytotoxicants. Am J Respir Cell Mol Biol 23(1):27-36. PMID:10873150


  • Shultz MA, Choudary P, Buckpitt AR. 1999. Role of murine CYP2F2 in the metabolic activation of naphthalene and in the metabolism of other xenobiotics. J Pharmacol Exp Ther 290(1):281-288. PMID:10381788
  • Watt KC, Morin D, Kurth M, Mercer RS, Plopper CG, Buckpitt AR. 1999. Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: Identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Chem Res Toxicol 12(9):831-839. PMID:10490505


  • Lakritz J, Plopper CG, Buckpitt AR. 1997. Validated high-performance liquid chromatography-electrochemical method for determination of glutathione and glutathione disulfide in small tissue samples. Anal Biochem 247(1):63-68. PMID:9126372


  • Lakritz J, Chang A, Weir AJ, Nishio SJ, Hyde D, Philpot RM, Buckpitt AR, Plopper CG. 1996. Cellular and metabolic basis of clara cell tolerance to multiple doses of cytochrome P450-activated cytotoxicants. I: Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenases in mice exposed to multiple doses of naphthalene. J Pharmacol Exp Ther 278(3):1408-1418. PMID:8819528
  • Van Winkle LS, Buckpitt AR, Plopper CG. 1996. Maintenance of differentiated murine clara cells in microdissected airway cultures. Am J Respir Cell Mol Biol 14(6):586-598. PMID:8652187


  • Buckpitt AR, Chang A, Weir AJ, Van Winkle LS, Duan X, Philpot RM, Plopper CG. 1995. Relationship of cytochrome P450 activity to Clara cell cytotoxicity. IV. Metabolism of naphthalene and naphthalene oxide in microdissected airways from mice, rats, and hamsters. Mol Pharmacol 47(1):74-81. PMID:7838135
  • Cho M, Chichester C, Plopper CG, Buckpitt AR. 1995. Biochemical factors important in Clara cell selective toxicity in the lung. J Mol Biol 27(1-2):369-386. PMID:7641583
  • Van Winkle LS, Buckpitt AR, Nishio SJ, Isaac JM, Plopper CG. 1995. Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice. Am J Physiol 269(6):L800-L818. PMID:8572242
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