Superfund Research Program

Burra V. Madhukar

Michigan State University
Department of Pediatrics and Human Development
B238B Life Sciences Bldg.
East Lansing, Michigan 48824
Phone: 517-432-3934
Fax: 517-432-4466
Email: madhukar@msu.edu

Projects

• Michigan State University: Activation of AhR-Dependent and AhR-Independent Signaling Cascades in PCB-Induced Immune Dysfunction (2000-2021)
• Michigan State University: Molecular Signals of Epigenetic Toxicity of Superfund Chemicals (1995 - 2000)

Publications

2004

• Linning KD, Tai M, Madhukar BV, Chang C, Reed DN, Ferber S, Trosko JE, Olson LK. 2004. Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential. Pancreas 29(3):E64-E76. PMID:15367896
• Madhukar BV, Chen G, Wood BF. 2004. PCB activation of extracellular signal-regulated kinases (ERKs) is mediated through epidermal growth factor receptor and intracellular calcium. Environ Health Perspect 78(S-1):Abst.1170.

2003

• Madhukar BV, Hernandez-Maldonado O. 2003. A diorthochlorinated PCB congener 2,2 ',4,4 '-tetrachlorobiphenyl (TCB) activates extracellular signal regulated kinases (ERKs) independent of protein kinase C (PKC) in JB6 mouse epidermal cells. Toxicol Sci 72(1):1574Suppl.S.
• Tai M, Olson LK, Madhukar BV, Linning KD, Van Camp LL, Tsao M, Trosko JE. 2003. Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with stem cell characteristics. Pancreas 26(1):e18-e26. PMID:12499933

2002

• Madhukar BV, Hernandez-Maldonado O. 2002. Di-ortho chlorine substituted PCB congeners activate mitogen-activated protein kinases independent of protein kianse C activation in JB-6 mouse epidermal cells. In: SOT 41^st Annual Meeting.

2001

• Ruch RJ, Trosko JE, Madhukar BV. 2001. Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation. J Cell Biochem 83(1):163-169. PMID:11500965

2000

• Ganey PE, Olivero-Verbal J, Madhukar BV. 2000. Mechanism of inhibition of stimulated neutrophil degranulation by 2,2',4,4'-tetrachlorobiphenyl. Toxicol Sci 54:77.
• Madhukar BV, Zeng XY, Hernandez O. 2000. Activation of extracellular signal regulated kinases (ERKs) by polychlorinated biphenyls in MCF-7 human breast cancer cells. In: Proceedings of the 1^st PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs (polychlorinated biphenyls), 2000. Lexington, KY. pp.no.30.
• Madhukar BV, Zeng XY, Hernandez O. 2000. Activation of extracellular signal-regulated kinases (ERKs) by 2,2',4,4'-tetrachlorobiphenyl in rat liver cells: Role of calcium. Environ Health Perspect 54:210.

1999

• Fischer L, Wagner MA, Madhukar BV. 1999. Potential involvement of calcium, CaM kinase II and MAP kinases in PCB-stimulated insulin release from RINm5F cells. Toxicol Appl Pharmacol 159:194-203. PMID:10486306

1998

• Fischer L, Madhukar BV, Zeng XY, Wagner MA. 1998. Activation of MAP kinases by polychlorinated biphenyls in rat insulinoma cells: correlation with insulin release. Environ Health Perspect 42:133.
• Madhukar BV. 1998. Modulation of protein kinases by xenobiotics. In: Toxicant-Receptor Interactions and Modulation of Gene Expression. Lippincott-Raven Publishers, Philadelphia, PA.
• Madhukar BV, Zeng XY, Fischer L. 1998. Polychlorinated biphenyls, transforming growth factor-alpha activate mitogen activated protein kinases in rat liver epithelial cells. Environ Health Perspect 42:133.
• Mousa MA, Ganey PE, Quensen JF, Madhukar BV, Chou K, Giesy JP, Fischer L, Boyd SA. 1998. Altered biological activity of commercial PCB mixtures due to microbial reductive dechlorination. In: Proceedings of the 17^th International Symposium on Chlorinated Dioxins and Related Compounds. pp.1-5.

1997

• Madhukar BV, Trosko JE. 1997. The causes of cancer: implications for prevention and treatment. Indian Journal of Pediatrics 64:131-141. PMID:10771828

1996

• Beavens JS, Little RA, Madhukar BV. 1996. Altered subcellular distribution of protein kinase C (PKC) isozymes in C3H 10T1/2 mouse embryo cells exposed to halogenated aromatic hydrocarbons (HAH). In: Proceedings of the 35^thAnnual Meeting of the Society of Toxicology Meeting, March 10-14, 1996. Anaheim, CA.
• Hayashi T, Hasler CM, Oh SY, Madhukar BV, Chang C, Trosko JE. 1996. Characterization of an in vitro human kidney epithelial system to study gap junctional intercellular communication. In Vitr Mol Toxicol 9:3-17.
• Madhukar BV, de Feijter-Rupp H, Trosko JE. 1996. Pulse treatment with tumor promoter TPA delays the onset of desensitization response and prolongs the inhibitory effect on gap junctional intercellular communication of a rat liver epithelial cell line WB F-344. Cancer Lett 106:117-123. PMID:8827055
• Madhukar BV, Little RA, Beavens JS. 1996. Non-coplanar polychlorinated biphenyls (PCBs) induce AP-1 transcription factor-mediated expression of Luciferase activity. In: Proceedings of the 35^thAnnual Meeting of the Society of Toxicology Meeting, March 10-14, 1996. Anaheim, CA.
• Madhukar BV, Quensen JF, Mousa MA, Fischer L, Boyd SA. 1996. Induction of AP-1 transcription factor activity by polychlorinated biphenyls (PCBs) and their microbial metabolites. In: Proceedings of the Forum on Environmental Remediation & Environmental Toxicology. Lansing, MI. pp.351-352.
• Madhukar BV, Zeng XY. 1996. Induction of AP-1 transcription factor-mediated gene expression by polychlorinated biphenyls (PCBs) in a rat pituitary cell line GH3. In: Proceedings of the 35^thAnnual Meeting of the Society of Toxicology Meeting, March 10-14, 1996. Anaheim, CA.
• Trosko JE, Chang C, Madhukar BV, Dupont E. 1996. Intercellular communication: A paradigm for the interpretation of the initiation/promotion/ progression model of carcinogenesis. In: Chemical Induction of Cancer: Modulation and Combination Effects. Birkhauser Publisher, Boston, MA. pp.3.17-3.29.

1995

• Madhukar BV. 1995. Implication of growth factor and growth factor receptor modulation in dioxin toxicity. Organohalogen Compounds 25:377-380.