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Your Environment. Your Health.

Person Details: Melpo Christofidou-Solomidou

Superfund Research Program

Melpo Christofidou-Solomidou

University of Pennsylvania
Perelman School of Medicine Pulmonary, Allergy & Critical Care Division
Stemmler Hall, Office Suite 227
3450 Hamilton Walk
Philadelphia, Pennsylvania 19104
Phone: 215-573-9917
Fax: 215-746-0376


Research Briefs




  • Pietrofesa RA, Chatterjee S, Kadariya Y, Testa JR, Albelda SM, Christofidou-Solomidou M. 2022. Synthetic secoisolariciresinol diglucoside (LGM2605) prevents asbestos-induced inflammation and genotoxic cell damage in human mesothelial cells. Int J Mol Sci 23(17):10085. doi:10.3390/ijms231710085 PMID:36077483 PMCID:PMC9456329


  • Chatterjee S, Pietrofesa RA, Park K, Tao J, Carabe-Fernandez A, Berman A, Koumenis C, Sielecki T, Christofidou-Solomidou M. 2019. LGM2605 reduces space radiation-induced NLRP3 inflammasome activation and damage in in vitro lung vascular networks. Int J Mol Sci 20(1):176. doi:10.3390/ijms20010176 PMID:30621290 PMCID:PMC6337675
  • Christofidou-Solomidou M, Pietrofesa RA, Park K, Albelda SM, Serve KM, Kiel DE, Pfau JC. 2019. Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice. Toxicol Appl Pharmacol 375:81-93. doi:10.1016/j.taap.2019.04.018 PMID:31022494 PMCID:PMC6582645
  • Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM, Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K. 2019. Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. J Mol Cell Cardiol 127:232-245. doi:10.1016/j.yjmcc.2018.12.016 PMID:30611795 PMCID:PMC6359996
  • Zhu B, Suzuki Y, DiSanto T, Rubin S, Penfil Z, Pietrofesa RA, Chatterjee S, Christofidou-Solomidou M, Cantu E. 2019. Applications of out of body lung perfusion. Acad Radiol 26(3):404-411. doi:10.1016/j.acra.2018.05.022 PMID:30054193 PMCID:PMC6345618


  • Chikara S, Mamidi S, Sreedasyam A, Pietrofesa RA, Zuppa A, Moorthy G, Dyer N, Christofidou-Solomidou M, Reindl KM. 2018. Flaxseed consumption inhibits chemically induced lung tumorigenesis and modulates expression of phase II enzymes and inflammatory cytokines in A/J mice. Cancer Prev Res (Phila) 11(1):27-37. doi:10.1158/1940-6207.CAPR-17-0119 PMID:29074535 PMCID:PMC5754250
  • Goodwin TJ, Christofidou-Solomidou M. 2018. Oxidative stress and space biology: An organ-based approach. Int J Mol Sci 19(4):959. doi:10.3390/ijms19040959 PMID:29570635 PMCID:PMC5979446
  • Mishra OP, Popov AV, Pietrofesa RA, Andrake M, Nakamaru-Ogiso E, Christofidou-Solomidou M. 2018. Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits myeloperoxidase activity in inflammatory cells. Biochim Biophys Acta 1862(6):1364-1375. doi:10.1016/j.bbagen.2018.03.003 PMID:29524540
  • Mohanty SK, Gonneau C, Salamatipour A, Pietrofesa RA, Casper BB, Christofidou-Solomidou M, Willenbring JK. 2018. Siderophore-mediated iron removal from chrysotile: implications for asbestos toxicity reduction and bioremediation. J Hazard Mater 341:290-296. doi:10.1016/j.jhazmat.2017.07.033 PMID:28797944 PMCID:PMC5771417
  • Pietrofesa RA, Chatterjee S, Park K, Arguiri E, Albelda SM, Christofidou-Solomidou M. 2018. Synthetic lignan secoisolariciresinol diglucoside (LGM2605) reduces asbestos-induced inflammation and inflammasome activation in mice in an Nrf2-dependent and independent manner. Antioxidants (Basel) 7(3):38. doi:10.3390/antiox7030038 PMID:29498660 PMCID:PMC5874524


  • Chikara S, Lindsey K, Dhillon H, Mamidi S, Kittilson J, Christofidou-Solomidou M, Reindl KM. 2017. Enterolactone induces G1-phase cell cycle arrest in non-small cell lung cancer cells by down-regulating cyclins and cyclin-dependent kinases. Nutr Cancer 69(4):652-662. doi:10.1080/01635581.2017.1296169 PMID:28323486 PMCID:PMC5500210
  • Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Koumenis C, Segal R. 2017. Radiation mitigating properties of intranasally administered KL4 surfactant in a murine model of radiation-induced lung damage. Radiation Research 188(5):491-504. doi:10.1667/RR14686.1 PMID:28877030 PMCID:PMC5704933
  • Pietrofesa RA, Woodruff P, Hwang W, Patel P, Chatterjee S, Albelda SM, Christofidou-Solomidou M. 2017. The synthetic lignan secoisolariciresinol diglucoside prevents asbestos-induced NLRP3 inflammasome activation in murine macrophages. Oxid Med Cell Longev 2017:739523. doi:10.1155/2017/7395238 PMID:29075366 PMCID:PMC5615985
  • Velalopoulou A, Chatterjee S, Pietrofesa RA, Koziol-White C, Panettieri RA, Lin L, Tuttle S, Berman A, Koumenis C, Christofidou-Solomidou M. 2017. Synthetic secoisolariciresinol diglucoside (LGM2605) protects human lung in an ex vivo model of proton radiation damage. Int J Mol Sci 18(12):E2525. doi:10.3390/ijms18122525 PMID:29186841 PMCID:PMC5751128


  • Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJ, Pietrofesa RA, Christofidou-Solomidou M, Cheung M, Mossman BT, Shukla A, Testa JR. 2016. Inflammation-related IL1β/IL1R signaling promotes the development of asbestos-induced malignant mesothelioma. Cancer Prev Res (Phila) 9(5):406-414. doi:10.1158/1940-6207.CAPR-15-0347 PMID:26935421 PMCID:PMC4854753
  • Mishra OP, Popov AV, Pietrofesa RA, Christofidou-Solomidou M. 2016. Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection. Biochim Biophys Acta 1860(9):1884-1897. doi:10.1016/j.bbagen.2016.05.037 PMID:27261092 PMCID:PMC5253237
  • Pietrofesa RA, Velalopoulou A, Albelda SM, Christofidou-Solomidou M. 2016. Asbestos induces oxidative stress and activation of Nrf2 signaling in murine macrophages: chemopreventive role of the synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605). Int J Mol Sci 17(3):322. doi:10.3390/ijms17030322 PMID:26938529 PMCID:PMC4813184
  • Pietrofesa RA, Velalopoulou A, Arguiri E, Menges CW, Testa JR, Hwang W, Albelda SM, Christofidou-Solomidou M. 2016. Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice. Carcinogenesis 37(2):177-187. doi:10.1093/carcin/bgv174 PMID:26678224 PMCID:PMC4745643
  • Pietrofesa RA, Velalopoulou A, Lehman SL, Arguiri E, Solomides P, Koch CJ, Mishra OP, Koumenis C, Goodwin TJ, Christofidou-Solomidou M. 2016. Novel double-hit model of radiation and hyperoxia-induced oxidative cell damage relevant to space travel. Int J Mol Sci 17(6):953. doi:10.3390/ijms17060953 PMID:27322243 PMCID:PMC4926486
  • Salamatipour A, Mohanty SK, Pietrofesa RA, Vann D, Christofidou-Solomidou M, Willenbring JK. 2016. Asbestos fiber preparation methods affect fiber toxicity. Environ Sci Technol Lett 3(7):270-274. doi:10.1021/acs.estlett.6b00174 PMID:27540559 PMCID:PMC4985249


  • Mesaros C, Worth AJ, Snyder NW, Christofidou-Solomidou M, Vachani A, Albelda SM, Blair IA. 2015. Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure. Bioanalysis 7(9):1157-1173. doi:10.4155/bio.15.53 PMID:26039812 PMCID:PMC4487641
  • Velalopoulou A, Tyagi S, Pietrofesa RA, Arguiri E, Christofidou-Solomidou M. 2015. The flaxseed-derived lignan phenolic secoisolariciresinol diglucoside (SDG) protects non-malignant lung cells from radiation damage. Int J Mol Sci 17(1):doi:10.3390/ijms17010007 PMID:26703588 PMCID:PMC4730254
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