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Your Environment. Your Health.

Person Details: Moon-shong Tang

Superfund Research Program

Moon-shong Tang

New York University School of Medicine
57 Old Forge Road

Tuxedo, New York 10987
Phone: 845-731-3585
Fax: 845-351-3492


Research Briefs



  • Hu L, Liu X, Chervona Y, Wang F, Tang M, Darzynkiewicz Z, Dai W. 2011. Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors. Cell Cycle 10:2373-2379. doi:10.4161/cc.10.14.16310 PMID:21670593 PMCID:PMC3230526 (Completed with ARRA Funds)


  • Feng Z, Hu W, Marnett LJ, Tang M. 2006. Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair. Mutat Res 601(1-2):125-36. PMID:16872641


  • Suen T, Tang M, Goss P. 2005. Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. Biochim Biophys Acta 1728(3):126-134. PMID:15777733


  • Feng Z, Hu W, Tang M. 2004. Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: A possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci U S A 101(23):8598-8602. PMID:15187227
  • Hu W, Feng Z, Tang M. 2004. Chromium(VI) enhances (+/-)-anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced cytotoxicity and mutagenicity in mammalian cells through its inhibitory effect on nucleotide excision repair. Biochemistry 43(44):14282-14289. doi:10.1021/bi048560o PMID:15518579
  • Hu W, Feng Z, Tang M. 2004. Nickel (II) enhances benzo[a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis. Carcinogenesis 25(3):455-462. PMID:14604891
  • Li J, Chen H, Ke Q, Feng Z, Tang M, Liu B, Amin S, Costa M, Huang C. 2004. Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappa B in mouse epidermal Cl41 cells. Mol Carcinog 40(2):104-115. PMID:15170815
  • Li J, Chen H, Tang M, Shi X, Amin S, Desai D, Costa M, Huang C. 2004. PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells. J Cell Biol 165(1):77-86. PMID:15067018
  • Li J, Tang M, Liu B, Shi X, Huang C. 2004. A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells. Oncogene 23(22):3932-3944. doi:10.1038/sj.onc.1207501 PMID:15021902
  • Yoon J, Besaratinia A, Feng Z, Tang M, Amin S, Luch A, Pfeifer GP. 2004. DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells. Cancer Res 64(20):7321-7328. doi:10.1158/0008-5472.CAN-04-1094 PMID:15492252


  • Chung F, Pan J, Choudhury S, Roy R, Hu W, Tang M. 2003. Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation. Mutat Res 531(1-2):25-36. PMID:14637245
  • Feng Z, Hu W, Amin S, Tang M. 2003. Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells. Biochemistry 42(25):7848-7854. PMID:12820894
  • Feng Z, Hu W, Rom WN, Costa M, Tang M. 2003. Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells. Carcinogenesis 24(4):771-778. PMID:12727806
  • Hu W, Feng Z, Tang M. 2003. Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms. Biochemistry 42(330:10012-10023. PMID:12924950


  • Feng Z, Hu W, Chen JX, Pao A, Li H, Rom WN, Hung M, Tang M. 2002. Carcinogen-DNA adducts are preferentially formed and poorly repaired at codon 12 of the K-ras gene, a mutation hotspot in lung cancers of cigarette smokers. J Natl Cancer Inst 90:1527-1536.
  • Feng Z, Hu W, Chen JX, Pao A, Li H, Rom WN, Hung M, Tang M. 2002. Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J Natl Cancer Inst 94(20):1527-1536. PMID:12381705
  • Feng Z, Hu W, Rom WN, Beland FA, Tang M. 2002. 4-aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene. Carcinogenesis 23(10):1721-1727. PMID:12376482
  • Feng Z, Hu W, Rom WN, Beland FA, Tang M. 2002. N-hydroxy-4-aminobiphenyl-DNA binding in human p53 gene: sequence preference and the effect of C5 cytosine methylation. Biochemistry 41(20):6414-6421. PMID:12009904
  • Hu W, Feng Z, Eveleigh J, Iyer G, Pan J, Amin S, Chung F, Tang M. 2002. The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis 23(11):1781-1789. PMID:12419825
  • Tang M, Pfeifer GP, Denissenko MF, Feng Z, Hu W, Pao A, Zheng Y, Zheng JB, Li H, Chen JX. 2002. Mapping polycyclic aromatic hydrocarbon and aromatic amine-induced DNA damage in cancer-related genes at the sequence level. Int J Hyg Environ Health 205(1-2):103-113. PMID:12018002
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