Superfund Research Program

Kevin M. Kleinow

Louisiana State University
Louisiana State University School of Veterinary Medicine
Baton Rouge, Louisiana 70803
Phone: 225-346-3256
Fax: 225-346-5736
Email: kleinow@vetmed.lsu.edu

Research Briefs

• 50 - Bioavailability of Chlorinated Hydrocarbons in the Diet

Publications

2014

• James MO, Kleinow KM. 2014. Seasonal influences on PCB retention and biotransformation in fish. Environ Sci Pollut Res Int 21(10):6324-6333. doi:10.1007/s11356-013-1611-3 PMID:23494683 PMCID:PMC3706481

2009

• Nyagode BA, James MO, Kleinow KM. 2009. Influence of dietary Coexposure to benzo(a)pyrene on the biotransformation and distribution of 14C-methoxychlor in the channel catfish (Ictalurus punctatus). Toxicol Sci 108(2):320-329. doi:10.1093/toxsci/kfp018 PMID:19181613 PMCID:PMC2664691

2006

• Stuchal L, Kleinow KM, Stegeman JJ, James MO. 2006. Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes. Drug Metab Dispos 34(6):932-8. PMID:16510540

2004

• James MO, Kleinow KM, Zhang Y, Zheng R, Wang L, Faux LR. 2004. Increased toxicity of benzo(a)pyrene-7,8-dihydrodiol in the presence of polychlorobiphenylols. Mar Environ Res 58(2-5):343-346. doi:10.1016/j.marenvres.2004.03.079 PMID:15178052
• Kleinow KM, Hummelke GC, Zhang Y, Uppu P, Baillif C. 2004. Inhibition of P-glycoprotein transport: a mechanism for endocrine disruption in the channel catfish?. Mar Environ Res 58(2-5):205-208. doi:10.1016/j.marenvres.2004.03.015 PMID:15178033

2003

• James MO, Kleinow KM, Zhang Y, Zheng R, Wang L, Faux LR. 2003. Inhibition of (-)-benzo(a)pyrene-7,8-dihydrodiol (BaP-7,8D) glucuronidation by a mixture of polychlorobiphenylols (OH-PCBs) results in increased DNA binding in a perfused channel catfish liver. In: Proceedings of the 12th International Symposium on Pollutant Responses in Marine Organisms. Safety Harbor, FL.
• Kleinow KM, Hummelke GC, Zhang Y, Uppu P, Baillif C. 2003. Inhibition of p-glycoprotein transport: a mechanism for endocrine disruption in the channel catfish?. In: Proceedings of the 12th International Symposium on Pollutant Responses in Marine Organisms. Safety Harbor, FL.
• Tan X, Zhang Y, Uppu P, Kleinow KM. 2003. The role of p-glycoprotein in the biliary excretion of tetracycline in catfish, Ictalurus punctatus. In: Proceedings of the 12th International Symposium on Pollutant Responses in Marine Organisms. Safety Harbor, FL.

2002

• Kleinow KM, Uppu P, Holmes E, Zhang Y. 2002. Alteration of p-glycoprotein expression in catfish by select environmental toxicants. Toxicol Sci 66:327.

2001

• Doi AM, Holmes E, Kleinow KM. 2001. P-glycoprotein in the catfish intestine: inducibility by xenobiotics and functional properties. Aquat Toxicol 55(3-4):157-170. PMID:11595306
• Fowler BA, Haasch ML, Kleinow KM, Squibb KS, Hayes AW. 2001. Organelles as Tools in Toxicology. In: Principles and Methods of Toxicology. 4th edition. Taylor and Francis, Philadelphia, PA. pp.1585-1624.
• James MO, Tong Z, Faux LR, Venugopal CS, Kleinow KM. 2001. Intestinal bioavailability and biotransformation of 3-hydroxybenzo(a)pyrene in an isolated perfused preparation from channel catfish, Ictalurus punctatus. Drug Metab Dispos 29(5):721-728. PMID:11302939
• Kleinow KM, James MO. 2001. Response of the teleost gastrointestinal system to xenobiotics. In: Target Organ Toxicity in Marine and Freshwater Teleosts. Taylor and Francis, New York, NY. pp.269-362.

2000

• Doi AM, Lou Z, Holmes E, Li CL, Venugopal CS, James MO, Kleinow KM. 2000. Effect of micelle fatty acid composition and 3,4,3',4'-tetrachlorobiphenyl (TCB) exposure on intestinal [14C]-TCB bioavailability and biotransformation in channel catfish in situ preparations. Toxicol Sci 55(1):85-96. PMID:10788563
• Kleinow KM. 2000. Autoradiography of fishes. In: Handbook of Experimental Animals -The Laboratory Fish. Academic Press, London, England. pp.579-588.
• Kleinow KM, Doi AM, Smith AA. 2000. Distribution and inducibility of P-glycoprotein in the catfish: immunohistochemical detection using the mammalian C-219 monoclonal. Mar Environ Res 50(1-5):313-317. PMID:11460710

1999

• Doi AM, Kleinow KM, Lou Z, James MO, Venugopalan CS, Holmes E. 1999. Bioavailability and biotransformation of 3,4,3',4'-tetrachlorobiphenyl (TCB) in in situ intestinal preparations of uninduced and TCB induced channel catfish. In: Proceedings of the PRIMO Meeting.
• Doi AM, Kleinow KM, Venugopalan CS, Holmes E. 1999. Multixenobiotic resistance mechanism in the catfish intestine. In: Proceedings of the PRIMO Meeting.
• Doi AM, Lou Z, Kleinow KM, James MO, Venugopalan CS, Holmes E. 1999. Effect of beta-naphthoflavone induction upon 3,4,3',4'-tetrachlorobiphenyl bioavailability in in situ preparations of channel catfish. Environ Health Perspect 48:262.
• Kleinow KM, Doi AM, Smith AA. 1999. Distribution of C219 detectable P-glycoprotein transporter in the catfish. In: Proceedings of the PRIMO Meeting.

1998

• Doi AM, Kleinow KM, James MO, Venugopalan CS, Holmes E. 1998. Bioavailability and biotransformation of 3,4,3',4'-tetrachlorobiphenyl (TCB) in in situ intestinal preparations of uninduced and TCB-induced channel catfish. Toxicol Sci 42:337.
• James MO, Kleinow KM, Li CL, Lou Z, Doi AM, Venugopalan CS, Holmes E. 1998. Intestinal bioavailability and biotransformation of 3,3',4,4'-tetrachlorobiphenyl. ISSX Proceedings 13:131.
• Kleinow KM, James MO, Tong Z, Venugopalan CS. 1998. Bioavailability and biotransformation of benzo(a)pyrene in an isolated perfused in situ catfish intestinal preparation. Environ Health Perspect 106:155-166. PMID:9449680

1996

• Kleinow KM, Venugopalan CS, Smith AA, Wiles JE, Holmes E. 1996. P-Glycoprotein distribution and inducibility in the catfish intestine: Role in benzo(a)pyrene (BaP) transport. Fundam Appl Toxicol 30:35.