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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Final Progress Reports: University of Washington: Environmental Stress Indicators for Fish at Superfund Sites: GC-MS and FT-IR Markers of Contaminant-Induced Damage to Gill Tissue

Superfund Research Program

Environmental Stress Indicators for Fish at Superfund Sites: GC-MS and FT-IR Markers of Contaminant-Induced Damage to Gill Tissue

Project Leader: Donald C. Malins (Pacific NW Research Institute)
Grant Number: P42ES004696
Funding Period: 1995 - 2006

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Final Progress Reports

Year:   2005  1999 

Winter flounder were caught at a reference site [St. George's Bay, Canada] and two urban sites on the East Coast of the United States: Eastern Cape Cod Bay and Deer Island Flats (DIF) in the Boston area. The study tests the hypothesis that analysis of DNA using Fourier transform-infrared (FT-IR) spectroscopy and gas chromatography-mass spectrometry (GC-MS) provides an important basis for monitoring the effects of chemical contamination on the health of aquatic species at Superfund sites. Analyses of DNA from the liver revealed significant modifications in DNA (mutagenic base lesions and other structural changes) that distinguished each of the groups. Statistical models based on these changes provide a promising basis for predicting health effects using the technologies employed.

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