Superfund Research Program
Arsenic and Innate Immunity in Human Lung
Project Leader: Bruce A. Stanton
Grant Number: P42ES007373
Funding Period: 2005-2020
The goal of this research is to test the hypothesis that arsenic exposure in water and food, relevant to the US population, causes disease by disrupting the innate immune response of the lungs to infection by Pseudomonas aeruginosa. The project has been focused on a major theme of the Dartmouth SRP Center—the effects of arsenic on human disease. In the last year, the team developed several novel computational and bioinformatics approaches to interrogate big data sets, including ScanGEO, an approach for parallel data mining of high-throughput gene expression data and an automated sample group detection approach of GEO microarray data and functional annotation of hypothetical genes using machine learning.