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Project Publications: Dartmouth College: Arsenic and Innate Immunity in Human Lung

Superfund Research Program

Arsenic and Innate Immunity in Human Lung

Project Leader: Bruce A. Stanton
Grant Number: P42ES007373
Funding Period: 2005-2021

Project-Specific Links



  • Howe CG, Armstrong DA, Muse ME, Gilbert-Diamond D, Gui J, Hoen AG, Palys T, Barnaby R, Stanton BA, Jackson BP, Christensen BC, Karagas MR. 2022. Periconceptional and prenatal exposure to metals and extracellular vesicle and particle miRNAs in human milk: a pilot study. Expo Health doi:10.1007/s12403-022-00520-1


  • Hampton TH, Jackson CE, Jung D, Chen CY, Glaholt SP, Stanton BA, Colbourne JK, Shaw JR. 2020. Conserved gene networks facilitate the osmotic shock response in killifish. Comp Biochem Physiol Part D Genomics Proteomics (in press)
  • Hsu KS, Goodale BC, Ely KH, Hampton TH, Stanton BA, Enelow RI. 2020. Single-cell RNA-seq analysis reveals that prenatal arsenic exposure results in long-term, adverse effects on immune gene expression in response to Influenza A infection. Toxicol Sci 176:312-328. doi:10.1093/toxsci/kfaa080 PMID:32514536 PMCID:PMC7416320
  • Li K, Gifford AH, Hampton TH, O'Toole GA. 2020. Availability of Zinc impacts interactions between streptococcus sanguinis and pseudomonas aeruginosa in coculture. J Bacteriol 202:doi:10.1128/jb.00618-19 PMID:31685535 PMCID:PMC6941532
  • Li Z, Holden VI, Neff SL, Koeppen K, Cengher L, Mould ED, Stanton BA, Hampton TH. 2020. Automated sample group detection of GEO microarray data and functional annotation of hypothetical genes using machine learning. Pac Symp Biocomput (in press)
  • Ruhr IM, Wood CM, Schauer KL, Wang Y, Mager EM, Stanton BA, Grosell M. 2020. Is aquaporin-3 involved in water-permeability changes in the killifish during hypoxia and normoxic recovery, in freshwater or seawater?. J Exp Zool A Ecol Integr Physiol 333(7):511-525. doi:10.1002/jez.2393 PMID:32548921 PMCID:PMC7405550



  • Hampton TH, Jackson CE, Jung D, Chen CY, Glaholt SP, Stanton BA, Colbourne JK, Shaw JR. 2018. Arsenic reduces gene expression response to changing salinity in killifish. Environ Sci Technol 52:8811-8821. doi:10.1021/acs.est.8b01550 PMID:29979584 PMCID:PMC6084426
  • Nachman KE, Punshon T, Rardin LR, Signes-Pastor AJ, Murray CJ, Jackson BP, Guerinot ML, Burke TA, Chen CY, Ahsan H, Argos M, Cottingham KL, Cubadda F, Ginsberg GL, Goodale BC, Kurzius-Spencer M, Meharg AA, Miller M, Nigra AE, Pendergrast CB, Raab A, Reimer K, Scheckel KG, Schwerdtle T, Taylor VF, Tokar EJ, Warczak TM, Karagas MR. 2018. Opportunities and challenges for dietary arsenic intervention. Environ Health Perspect 126(8):084503-1-6. doi:10.1289/EHP3997 PMID:30235424 PMCID:PMC6375412



  • Gifford AH, Willger SD, Dolben E, Moulton LA, Dorman DB, Bean H, Hill J, Hampton TH, Ashare A, Hogan DA. 2016. Use of a Multiplex Transcript Method for Analysis of Pseudomonas aeruginosa Gene Expression Profiles in the Cystic Fibrosis Lung. Infect Immun 84(10):2995-3006. doi:10.1128/IAI.00437-16 PMID:27481238 PMCID:PMC5038062
  • Greene CS, Stanton BA, Hogan DA, Bromberg Y. 2016. Computational approaches to study microbes and microbiomes. Pac Symp Biocomput 21:557-567. PMID:26776218 PMCID:PMC4832978
  • Hogan DA, Willger SD, Dolben E, Hampton TH, Stanton BA, Morrison HG, Sogin ML, Czum J, Ashare A. 2016. Analysis of lung microbiota in bronchoalveolar lavage, protected brush and sputum samples from subjects with mild-to-moderate cystic fibrosis lung disease. PLoS One 11(3):e0149998. doi:10.1371/journal.pone.0149998 PMID:26943329 PMCID:PMC4778801
  • Koeppen K, Hampton TH, Jarek M, Scharfe M, Gerber SA, Mielcarz DW, Demers EG, Dolben E, Hammond JH, Hogan DA, Stanton BA. 2016. A novel mechanism of host-pathogen interaction through sRNA in bacterial outer membrane vesicles. PLoS Pathog 12(6):e1005672. doi:10.1371/journal.ppat.1005672 PMID:27295279 PMCID:PMC4905634



  • Bomberger JM, Ely KH, Bangia N, Ye S, Green KA, Green WR, Enelow RI, Stanton BA. 2014. Pseudomonas aeruginosa Cif enhances the ubiquitination and proteasomal degradation of the transporter associated with antigen processing (TAP) and reduces MHC class I antigen presentation. J Biol Chem 289:152-162. doi:10.1074/jbc.M113.459271 PMID:24247241 PMCID:PMC3879540
  • Gifford AH, Alexandru DM, Li Z, Dorman DB, Moulton LA, Price KE, Hampton TH, Sogin ML, Zuckerman JB, Parker HW, Stanton BA, O'Toole GA. 2014. Iron supplementation does not worsen respiratory health or alter the sputum microbiome in cystic fibrosis. Journal of Cystic Fibrosis doi:10.1016/j.jcf.2013.11.004 PMID:24332997 PMCID:PMC3972336
  • Shaw JR, Hampton TH, King BL, Whitehead A, Galvez F, Gross RH, Keith N, Notch E, Jung D, Glaholt SP, Chen CY, Colbourne JK, Stanton BA. 2014. Natural selection canalizes expression variation of environmentally induced plasticity-enabling genes. Mol Biol Evol 31(11):3002-3015. doi:10.1093/molbev/msu241 PMID:25158801 PMCID:PMC4209136
  • Torres IM, Patankar YR, Shabaneh TB, Dolben E, Hogan DA, Leib DA, Berwin BL. 2014. Acidosis potentiates the host proinflammatory interleukin-1β response to Pseudomonas aeruginosa infection. Infect Immun 82(11):4689-4697. doi:10.1128/IAI.02024-14 PMID:25156732 PMCID:PMC4249319


  • Jackson AA, Gross MJ, Daniels EF, Hampton TH, Hammond JH, Dove SL, Stanton BA, Hogan DA. 2013. Anr, and its activation by PlcH activity, in Pseudomonas aeruginosa host colonization and virulence. J Bacteriol 195:3093-3104. doi:10.1128/JB.02169-12 PMID:23667230 PMCID:PMC3697539
  • Moreau-Marquis S, Coutermarsh BA, Jackson BP, Stanton BA. 2013. The ∆F508 Mutation of CFTR alters the polarized distribution of DMT1 and ferroportin in human airway epithelial cells. FASEB J 27(1):
  • Zhou Y, Song K, Painter RG, Aiken M, Reiser J, Stanton BA, Nauseef WM, Wang G. 2013. Cystic fibrosis transmembrane conductance regulator recruitment to phagosomes in neutrophils. J Innate Immun 5:219-230. doi:10.1159/000346568 PMID:23486169 PMCID:PMC3717385


  • Bomberger JM, Coutermarsh BA, Stanton BA. 2012. Arsenic promotes ubiquitinylation and lysosomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels in human airway epithelial cells. J Biol Chem 287:17130-17139. doi:10.1074/jbc.M111.338855 PMID:22467879 PMCID:PMC3366821
  • Jung D, MacIver B, Jackson BP, Barnaby R, Sato J, Zeidel ML, Shaw JR, Stanton BA. 2012. A novel Aquaporin 3 in Killifish (Fundulus heteroclitus) is not an arsenic channel. Toxicol Sci 127(1):101-109. doi:10.1093/toxsci/kfs078 PMID:22323512 PMCID:PMC3327866
  • Jung D, Sato J, Shaw JR, Stanton BA. 2012. Expression of aquaporin 3 in gills of the Atlantic killifish (Fundulus heteroclitus): Effects of seawater acclimation. Comp Biochem Physiol A Mol Integr Physiol 161(3):320-326. doi:10.1016/j.cbpa.2011.11.014 PMID:22193757 PMCID:PMC3264823
  • Madan JC, Koestler DC, Stanton BA, Davidson L, Moulton LA, Housman ML, Moore JH, Guill MF, Morrison HG, Sogin ML, Hampton TH, Karagas MR, Palumbo PE, Foster JA, Hibberd PL, O'Toole GA. 2012. Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: Interactions between intestinal and respiratory tracts and impact of nutritional exposures. MBio 3(4):e00251-12. doi:10.1128/mBio.00251-12 PMID:22911969 PMCID:PMC3428694
  • Notch EG, Chapline CM, Flynn E, Lameyer T, Lowell A, Sato J, Shaw JR, Stanton BA. 2012. Mitogen Activated protein kinase 14 regulates serum glucocorticoid kinase 1 during seawater acclimation in Atlantic killifish Fundulus heteroclitus. Comp Biochem Physiol A Mol Integr Physiol 162(4):443–448. doi:10.1016/j.cbpa.2012.04.025 PMID:22575607 PMCID:PMC3365625


  • Fadul CE, Fisher JL, Côté AL, Ernstoff MS. 2011. Immune modulation effects of concomitant temozolomide and radiation therapy on peripheral blood mononuclear cells in patients with glioblastoma multiforme. Neuro Oncol 13(4):393-400. doi:10.1093/neuonc/noq204 PMID:21339188 PMCID:PMC3064696 (Completed with ARRA Funds)
  • Fadul CE, Fisher JL, Hampton TH, Lallana EC, Li Z, Gui J, Szczepiorkowski ZM, Tosteson TD, Rhodes C, Wishart HA, Lewis LD, Ernstoff MS. 2011. Immune response in patients with newly diagnosed glioblastoma multiforme treated with intranodal autologous tumor lysate-dendritic cell vaccination after radiation chemotherapy. J Immunother 34(4):382-389. doi:10.1097/CJI.0b013e318215e300 PMID:21499132 PMCID:PMC3766324
  • Gilbert-Diamond D, Moore JH. 2011. Analysis of gene-gene interactions. Chapter 1 in: Current Protocols in Human Genetics. Wiley,
  • Notch EG, Shaw JR, Coutermarsh BA, Dzoiba M, Stanton BA. 2011. Morpholino gene knockdown in adult Fundulus heteroclitus: role of SGK1 in seawater acclimation. PLoS One 6(12):e29462. doi:10.1371/journal.pone.0029462 PMID:22216285 PMCID:PMC3245286



  • Davis AP, Murphy CG, Saraceni-Richards CA, Rosenstein MC, Wiegers TC, Hampton TH, Mattingly CJ. 2009. GeneComps and ChemComps: a new CTD metric to identify genes and chemicals with shared toxicogenomic profiles. Bioinformation 4(4):173-174. PMID:20198196 PMCID:PMC2825594
  • Mattingly CJ, Hampton TH, Brothers KM, Griffin NE, Planchart A. 2009. Perturbation of defense pathways by low-dose arsenic exposure in zebrafish embryos. Environ Health Perspect 117(6):981-987. doi:10.1289/ehp.0900555 PMID:19590694 PMCID:PMC2702417


  • Ye S, MacEachran DP, Hamilton JW, O'Toole GA, Stanton BA. 2008. Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif. Am J Physiol Cell Physiol 295(3):C807-C818. doi:10.1152/ajpcell.00234.2008 PMID:18650266 PMCID:PMC2544439


  • Miller DS, Shaw JR, Stanton CR, Barnaby R, Karlson KH, Hamilton JW, Stanton BA. 2007. MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus). Toxicol Sci 97(1):103-110. doi:10.1093/toxsci/kfm030 PMID:17324950
  • Sato J, Chapline CM, Thibodeau R, Frizzell R, Stanton BA. 2007. Regulation of human cystic fibrosis transmembrane conductance regulator (CFTR) by serum- and glucocorticoid-inducible kinase (SGK1). Cell Physiol Biochem 20(1-4):91-98. doi:10.1159/000104157 PMID:17595519
  • Shaw JR, Gabor K, Hand E, Lankowski A, Durant L, Thibodeau R, Stanton CR, Barnaby R, Coutermarsh BA, Karlson KH, Sato J, Hamilton JW, Stanton BA. 2007. Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic. Am J Physiol Regul Integr Comp Physiol 292(2):R1052-R1060. doi:10.1152/ajpregu.00328.2006 PMID:17038445
  • Shaw JR, Jackson BP, Gabor K, Stanton S, Hamilton JW, Stanton BA. 2007. The influence of exposure history on arsenic accumulation and toxicity in the killifish, Fundulus heteroclitus. Environ Toxicol Chem 26:2704-2709. PMID:18020683


  • Stanton BA, Guggino WB. 2006. New insights into cystic fibrosis: molecular switches that regulate CFTR. Nat Rev Mol Cell Biol 7(6):426-436. doi:10.1038/nrm1949 PMID:16723978
  • Stanton CR, Thibodeau R, Lankowski A, Shaw JR, Hamilton JW, Stanton BA. 2006. Arsenic inhibits CFTR-mediated chloride secretion by killifish (Fundulus heteroclitus) opercular membrane. Cell Physiol Biochem 17(5-6):269-78. PMID:16791002
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