Superfund Research Program
Trace Elements Analysis Core
The Trace Elements Analysis Core has analyzed samples for all Dartmouth SRP projects in support of their research goals. The Core has also participated in Proficiency tests organized by Brooks Rand Labs (mercury species in water and arsenic species in foods), Center for toxicology, Quebec (total metals in blood, urine, serum, hair), and the Centers for Disease Control and Prevention (arsenic species in urine) -- the objective being to provide third-party assurance of the ability of the Core to provide accurate and precise results.
The Core greatly improved the analytical infrastructure with the purchase of a triple quadrupole inductively coupled plasma mass spectrometer (ICP-QQQ). The new instrument was funded by Dartmouth SRP, Dartmouth College, Dartmouth Earth Science Department, Dartmouth Children's Center for Environmental Health and Disease Prevention, and Dartmouth's Norris Cancer Center. The ICP-QQQ provides significantly lower detection limits for all elements and is particularly relevant for Dartmouth's arsenic research. New analytical methodologies will be developed using the unique features of this new instrument.
The Core PI, Brian Jackson, gave two talks for the New England section of the American Chemical Society at Woods Hole, Massachusetts and Dartmouth College, New Hampshire, entitled "Arsenic in the U.S. food and water supply". The talks were open to the general public, and both were well attended.
Jackson B, Liba A, Nelson J. 2015. Advantages of reaction cell ICP-MS on doubly charged interferences for arsenic and selenium analysis in foods. J Anal At Spectrom. DOI:10.1039/C4JA00310A.
Davis MA, Li Z, Gilbert-Diamond D, Mackenzie TA, Cottingham KL, Jackson BP, Lee JS, Baker ER, Marsit CJ, Karagas MR. 2014. Infant toenails as a biomarker of in utero arsenic exposure. J Expo Sci Environ Epidemiol. 24(5):467-473.
Taylor VF, Bugge D, Jackson BP, Chen CY. Pathways of CH3Hg and Hg ingestion in benthic organisms: an enriched isotope approach. Environ Sci Technol. 48(9):5058-5065.
Gosse JA, Taylor VF, Jackson BP, Hamilton JW, Bodwell JE. 2014. Monomethylated trivalent arsenic species disrupt steroid receptor interactions with their DNA response elements at non-cytotoxic cellular concentrations. J Appl Toxicol. 34(5):498-505.
Beal SA, Jackson BP, Kelly MA, Stroup JS, Landis JD. 2013. Effects of historical and modern mining on mercury deposition in southeastern Peru. Environ Sci Technol. 47(22):12715-12720.
Richardson JB, Friedland AJ, Engerbretson TR, Kaste JM, Jackson BP. 2013. Spatial and vertical distribution of mercury in upland forest soils across the northeastern United States. Environ Pollut. 182:127-134.