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Your Environment. Your Health.

Progress Reports: Dartmouth College: Training Core

Superfund Research Program

Training Core

Project Leader: Bruce A. Stanton
Grant Number: P42ES007373
Funding Period: 2000-2020
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Progress Reports

Year:   2019  2018  2017  2016  2015  2014  2013  2012  2011  2010  2009  2008  2007  2006  2005  2004 

During the past year the Training Core supported two graduate students (Athena Nomikos - Arsenic as an Endocrine Disruptor project; Colette Quinn - Toxic Metal Interactions with Cellular Proteins project) and two postdoctoral fellows (Julia Gosse - Arsenic as an Endocrine Disruptor project; Tracy Punshon - Metal Ion Homeostasis in Plants pilot project).

  • Athena Nomikos is a third year Ph.D. student (Pharmacology & Toxicology) who has been working with Joshua Hamilton on the Arsenic as an Endocrine Disruptor project.  She is studying the role of arsenic as an endocrine disruptor, including the effects of low arsenic doses on thyroid receptor-mediated gene expression and the effects of arsenic exposure on pathways in the mouse liver, including the cholesterol biosynthesis pathway.  She attended the January, 2006 Annual SBRP Meeting in New York, NY, the February, 2006 35th Annual Meeting of New England Pharmacologists in Waltham, MA, and the July, 2006 Environmental Health Sciences Symposium at the Mount Desert Island Biological Laboratory in Bar Harbor, ME; at each meeting she presented a poster on her research. In addition, she will attend the December, 2006 Annual SBRP Meeting in La Jolla, CA, where she will give an invited talk.  She has taken 5 graduate courses this year and published a paper, J.E. Bodwell, J.A. Gosse, A.P. Nomikos, J.W. Hamilton,"Arsenic disruption of steriod receptor gene activation:  Complex dose-response effects are shared by several steroid receptors," Chemical Research in Toxicology, 2006.  
  • Colette Quinn is a second year Ph.D. student (Chemistry) who recently started working with Dean Wilcox on the Toxic Metal Interactions with Cellular Proteins project.  She is studying the thermodyamics of toxic metals binding to the heavy metal detoxifying protein metallothionein.  This year she took the graduate inorganic biochemistry course, she is making excellent progress on her degree requirements and she regularly attends Dartmouth SBRP meetings.
  • Julia Gosse Ph.D. is a second year postdoctoral fellow working with Joshua Hamilton on the Arsenic as an Endocrine Disruptor project.  She is investigating the toxicogenomics, carcinogenesis, and interference with endocrine signaling due to arsenic in telomerase-immortalized normal cells and in tissue from mice exposed to low arsenic doses via ingestion; she has also used fluorescence polarization to measure arsenic disruption of steroid receptors binding to their DNA response elements.  She attended the January, 2006 Annual SBRP Meeting in New York City, where she presented a poster, and the July, 2006 Environmental Health Sciences Symposium at Mount Desert Island Biological Laboratory in Bar Harbor, ME, where she presented 2 posters.  In addition, she has mentored two graduate rotation students and an undergraduate student, audited the graduate toxicology course, and published a paper, J.E. Bodwell, J.A. Gosse, A.P. Nomikos, J.W. Hamilton,"Arsenic disruption of steriod receptor gene activation:  Complex dose-response effects are shared by several steroid receptors," Chemical Research in Toxicology, 2006.
  • Tracy Punshon Ph.D. is a second year postdoctoral fellow who is working with Mary Lou Guerinot (Dartmouth Professor of Biology) on a pilot project that uses functional ionomics and the synchrotron X-ray microprobe to study metal ion homeostasis in plants, with potential relevance to toxic metal exposure in food, which is related to the overall goals of the Dartmouth Superfund Program.  She attended the August, 2006 Annual Meeting of the American Society of Plant Biologists in Boston, MA, where she presented a poster and co-author an oral presentation, and the September, 2005 Synchrotron Environmental Sciences III meeting at the National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY, where she presented 2 posters; in addition, she will attend the December, 2006 Annual SBRP Meeting in La Jolla, CA.  This past year she taught a class in the graduate inorganic biochemistry course, and published a paper on her research, S.A. Kim, T. Punshon, A. Lanzirotti, L. Liangtao, J.M. Alonso, J.R.  Ecker, J. Kaplan, M.L. Guerinot, "Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1" Science, 2006, in press.

In addition to these four individuals who are directly supported by the Training Core, there are a number of graduate students, post-doctoral fellows and undergraduates who are supported by the individual projects.  They have been similarly successful in their research, dedicated to educational and mentoring opportunities and active at professional meetings, and they contribute actively to the program.

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