Superfund Research Program
Project Leader: Bruce A. Stanton
Grant Number: P42ES007373
Funding Period: 2000-2020
During the past year the Training Core supported three continuing graduate students (James Jukosky – Project 7; Roxanne Karimi – Project 7; Callie Schieffer – Projects 2 and 5) and three postdoctoral fellows (Lorenzo Perna – TEA Core B and Project 7; Anne Spuches - Projects 2 and 5, Joseph Shaw - Projects 2 and 7). Nicole Soucy completed her Ph.D. dissertation research on “Induction of angiogenesis by arsenic: mechanisms for arsenic-induced vascular disease” and was awarded her Ph.D. (Pharmacology & Toxicology, Dartmouth Medical School) in 2003. Her manuscript from this thesis, describing how arsenic-induced angiogenesis enhances tumor growth (Tox Sci 76: 271-279, 2003), was unanimously voted as the best paper in Toxicological Sciences for 2003 by their editorial board. Nicole will receive this award at the March 2005 Society of Toxicology Meeting in New Orleans. Nicole is now a post-doctoral fellow at the Chemical Industry Institute for Toxicology studying maternal-fetal transport of phyto-estrogen compounds. Graduate student Callie Schieffer is continuing her collaborative interdisciplinary studies aimed at understanding at the structural level the precise targets of attack by toxic metals such as arsenic and cadmium on zine finger proteins such as the glucocorticoid receptor which is the focus of Projects 2 and 5. Graduate student James Jukosky is in the process of completing a Master’s degree working on metal uptake in Daphnia as part of Project 7. He plans to work in the field of ecotoxicology before continuing on for a Ph.D. degree. Roxanne Karimi is continuing toward her Ph.D., working in Project 7 on trophic transfer of metals in aquatic species and the energy costs associated with this process. Postdoctoral Fellow Anne Spuches is working in Project 5 on coordination of toxic metals into zinc finger sites of key proteins such as the glucocorticoid receptor that are the focus of other projects, in particular collaborating with Project 2. Dr. Spuches recently received the 2004 Karen E. Wetterhahn Memorial Award from the national SBRP program, and presented her research at the Annual SBRP Meeting in Seattle WA in November 2004. Postdoctoral Fellow Joseph Shaw Ph.D. is continuing his collaborative studies of metal toxicology in killifish (Project 2) and Daphnia (Projects 2 and 7), combining molecular and genomics techniques with ecotoxicology studies. Postdoctoral Fellow Lorenzo Perna continued his studies with Dr. Stefan Sturup in the Trace Metals Core to develop novel methods of ultratrace metal detection and speciation. This year, students funded through the Training Core conducted their own research projects, visited middle school classrooms in the region and collaborated on the core’s Environmental Detectives outreach project and participated in program-sponsored activities such as the Dartmouth SBRP hosted Annual Superfund Basic Research Program Meeting. They also attended or presented research in seminars and symposia, retreats and national research meetings such as the 2004 Society of Toxicology (SOT), Society of Environmental Toxicology and Chemistry (SETAC), and American Chemical Society (ACS) annual meetings.