Superfund Research Program
Zebrafish as a Detector and Discriminator of Organophosphate Exposure
Dr. Linney's team is using fluorescent zebrafish embryos to detect whether environmental toxicants can visibly effect the expression of fluorescent biosensor genes. These embryos have been exposed to chemicals like chlorpyrifos and results indicate that exposure to high run-off levels can affect the development of the embryonic muscle, notochord and nervous system. Project investigators are determining whether lower levels of exposure will also effect such changes. In additional experiments, researchers are investigating whether environmental toxicants can impact the retinoic acid signal transduction pathway and thereby affect the proper development of the embryonic neural tube.