Superfund Research Program

Elwood A. Linney

Duke University Medical Center
Duke Medical Center
Box 3020 Med Ctr.
Durham, North Carolina 27710
Phone: 919-684-6095
Fax: 919-684-8735
Email: elwood.linney@duke.edu

Projects

• Duke University: Transgenic Fish Facility (2000 - 2005)
• Duke University: Zebrafish as a Detector and Discriminator of Organophosphate Exposure (2000-2011)

Research Briefs

• 102 - Multidisciplinary Research to Develop Models to Study the Impacts of Exposure to Chlorpyrifos

Publications

2014

• Hahn ME, McArthur AG, Karchner SI, Franks DG, Jenny MJ, Timme-Laragy AR, Stegeman JJ, Woodin BR, Cipriano MJ, Linney EA. 2014. The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. PLoS One 9(11):e113158. doi:10.1371/journal.pone.0113158 PMID:25402455 PMCID:PMC4234671

2012

• Roy NM, Arpie B, Linney EA, Levin ED, Cerutti DT, Lugo J. 2012. Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of Embryonic synaptic changes. Neurotoxicol Teratol 34:587-591. doi:10.1016/j.ntt.2012.08.001 PMID:23022260 PMCID:PMC4338986

2011

• Levin ED, Petro A, Donerly S, Linney EA, Sledge D, Roach S. 2011. Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicol Teratol 33:668-673. doi:10.1016/j.ntt.2011.06.004 PMID:21741476 PMCID:PMC3225500
• Sledge D, Yen J, Morton T, Dishaw L, Petro A, Donerly S, Linney EA, Levin ED. 2011. Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicol Teratol 33:742-751. doi:10.1016/j.ntt.2011.06.005 PMID:21745564 PMCID:PMC3225562
• Yen J, Donerly S, Levin ED, Linney EA. 2011. Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicol Teratol 33:735-741. doi:10.1016/j.ntt.2011.10.004 PMID:22036888 PMCID:PMC3225599

2010

• Alexeyenko A, Wassenberg DM, Lobenhofer EK, Yen J, Linney EA, Sonnhammer E, Meyer JN. 2010. Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. PLoS One 5(5):e10465. doi:10.1371/journal.pone.0010465 PMID:20463971 PMCID:PMC2864754
• Powers CM, Yen J, Linney EA, Seidler FJ, Slotkin TA. 2010. Silver exposure in developing zebrafish (Danio rerio): persistent effects on larval behavior and survival. Neurotoxicol Teratol 32(3):391-397. doi:10.1016/j.ntt.2010.01.009 PMID:20116428 PMCID:PMC2854181

2009

• Levin ED, Aschner M, Heberlein U, Ruden D, Welsh-Bohmer KA, Bartlett S, Berger K, Chen L, Corl AB, Eddins D, French R, Hayden KM, Helmcke K, Hirsch HV, Linney EA, Lnenicka G, Page GP, Possidente D, Possidente B, Kirshner A. 2009. Genetic aspects of behavioral neurotoxicology. Neurotoxicology 30(5):741-753. doi:10.1016/j.neuro.2009.07.014 PMID:19647018 PMCID:PMC4086839
• Timme-Laragy AR, Van Tiem LA, Linney EA, Di Giulio RT. 2009. Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Toxicol Sci 109(2):217-227. doi:10.1093/toxsci/kfp038 PMID:19233942 PMCID:PMC2721659

2007

• Beyer RP, Lasarev MR, Meira LB, Palmer VS, Ross PK, Bammler TK, Bradford BU, Cunningham ML, Higgins G, Hurban P, Kayton RJ, Kosyk O, Vliet PA, Wolfinger R, Woods CG, Freedman JH, Linney EA, Kaufmann WK, Kavanagh TJ, Rusyn I, Samson LD, Spencer PS, Suk WA, Zarbl HF. 2007. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 99(1):326-337. PMID:17562736
• Lassiter CS, Linney EA. 2007. Embryonic expression and steroid regulation of brain aromatase cyp19a1b in zebrafish (Danio rerio). Zebrafish 4(1):49-57. doi:10.1089/zeb.2006.9995 PMID:18041942

2006

• Cook J, Denslow ND, Iguchi T, Linney EA, Miracle A, Shaw JR, Viant MR, Zacharewski TR. 2006. "Omics" approaches in the context of environment toxicology. (In: Emerging Molecular and Computational Approaches for Cross-Species Extrapolations). Chapter 1in: Society of Environmental Toxicology and Chemistry (SETAC) Annual Meeting 2006. Washington, DC. pp.1-29.
• Cook J, Denslow ND, Iguchi T, Linney EA, Miracle AL, Shaw JR, Viant MR, Zacharewski TR. 2006. "Omics" approaches in the context of human and environmental toxicology. Chapter 1 in: Genomic Approaches for Cross-Species Extrapolation in Toxicology. pp.1-25.

2004

• Levin ED, Swain HA, Donerly S, Linney EA. 2004. Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior. Neurotoxicol Teratol 26(6):719-723. PMID:15451035
• Linney EA, Udvadia AJ. 2004. Construction and detection of fluorescent germline transgenic zebrafish. Chapter Vol. 254 in: Methods in Molecular Biology, 2004. Humana Press, Inc, Louisville, KY. pp.271-288.
• Linney EA, Upchurch L, Donerly S. 2004. Zebrafish as a neurotoxicological model. Neurotoxicol Teratol 26(6):709-718. PMID:15451034

2003

• Levin ED, Chrysanthis E, Yacsin K, Linney EA. 2003. Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicol Teratol 25(1):51-57. PMID:12633736
• Linney EA, Udvadia AJ. 2003. Construction and detection of fluorescent germ-line transgenic zebrafish. In: Methods Mol Med. (). Humana Press,
• Udvadia AJ, Linney EA. 2003. Windows into development: historic, current, and future perspectives on transgenic zebrafish. Dev Biol 256(1):1-17. PMID:12654288

2002

• Lassiter CS, Linney EA, Kelley B. 2002. Genomic structure and embryonic expression of estrogen receptor beta a (ERBa) in zebrafish (Danio rerio). Gene 292(1-2):141-151. doi:10.1016/S0378-1119(02)01050-8 PMID:12459262