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University of North Carolina-Chapel Hill: Dataset Details, ID=GSE42394

Superfund Research Program

Biomarkers of Exposure versus Effect: Improving the Scientific Basis for Risk Assessment

Project Leader: James A. Swenberg
Grant Number: P42ES005948
Funding Period: 1995-2018
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Title: Formaldehyde-induced changes in microRNA signaling [Affymetrix]

Accession Number: GSE42394

Link to Dataset:

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by array

Organism(s): Rattus norvegicus

Summary: In addition to gaining knowledge on in vivo miRNA responses to formaldehyde, we set out to relate these miRNA responses to transcriptional profiles modified by formaldehyde. Rats were exposed by inhalation to either 0 or 2 ppm formaldehyde (6 hours/day) for 28 days. Genome-wide transcriptional profiles and associated signaling pathways were assessed within the nasal respiratory mucosa and circulating mononuclear white blood cells (WBC).

Publication(s) associated with this dataset:
  • Rager JE, Moeller BC, Miller SK, Kracko D, Doyle-Eisele M, Swenberg JA, Fry RC. 2014. Formaldehyde-associated changes in microRNAs: tissue and temporal specificity in the rat nose, white blood cells, and bone marrow. Toxicol Sci 138(1):36-46. doi:10.1093/toxsci/kft267 PMID:24304932 PMCID:PMC3930361
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