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Your Environment. Your Health.

Person Details

Superfund Research Program

James A. Swenberg

University of North Carolina-Chapel Hill
Department of Environmental Sciences and Engineering
253C Rosenau Hall, CB# 7431
Chapel Hill, NC 27599-7431
Phone: 919-966-6139
Fax: 919-966-6123
Email: james_swenberg@unc.edu

Projects

Research Briefs

Patents

Hazardous Waste Sites

Ciba-Giegy Corp. Site

  • University of North Carolina-Chapel Hill: Biomarkers of Exposure versus Effect: Improving the Scientific Basis for Risk Assessment

Hudson River PCBs

  • University of North Carolina-Chapel Hill: Biomarkers of Exposure versus Effect: Improving the Scientific Basis for Risk Assessment

Publications

2016

  • Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, Liu Y, Byrum SD, Mackintosh SG, Zhong M, Tackett A, Wang G, Hon LS, Fang G, Swenberg JA, Xiao AZ. 2016. DNA methylation on N(6)-adenine in mammalian embryonic stem cells. Nature532(7599):329-333. doi:10.1038/nature17640 PMID:27027282

2015

2014

2013

2012

  • Lu K, Craft S, Nakamura J, Moeller BC, Swenberg JA. 2012. Use of LC-MS/MS and Stable Isotopes to Differentiate Hydroxymethyl and Methyl DNA Adducts from Formaldehyde and Nitrosodimethylamine. Chem Res Toxicol25(3):664-675. doi:10.1021/tx200426b
  • Lu K, Gul H, Upton PB, Moeller BC, Swenberg JA. 2012. Formation of Hydroxymethyl DNA Adducts in Rats Orally Exposed to Stable Isotope Labeled Methanol. Toxicological Sciences126(1):28-38. doi:10.1093/toxsci/kfr328
  • Mutlu E, Jeong Y, Collins LB, Ham AL, Upton PB, Hatch G, Winsett D, Evansky P, Swenberg JA. 2012. A New LC-MS/MS Method for the Quantification of Endogenous and Vinyl Chloride-Induced 7-(2-Oxoethyl)Guanine in Sprague–Dawley Rats. Chem Res Toxicol25(2):391-399. doi:10.1021/tx200447w
  • Nakamura J, Gul H, Tian X, Bultman SJ, Swenberg JA. 2012. Detection of PIGO-Deficient Cells Using Proaerolysin: A Valuable Tool to Investigate Mechanisms of Mutagenesis in the DT40 Cell System. PLoS One7(3):e33563. doi:10.1371/journal.pone.0033563

2011

  • Adami H, Berry CL, Breckenridge CB, Smith LL, Swenberg JA, Trichopoulos D, Weiss NS, Pastoor TP. 2011. Toxicology and Epidemiology: Improving the Science with a Framework for Combining Toxicological and Epidemiological Evidence to Establish Causal Inference. Toxicological Sciences122(2):223-234. doi:10.1093/toxsci/kfr113
  • Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y. 2011. Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine. Science333(6047):1300-1303. doi:10.1126/science.1210597
  • Jung D, Matson CW, Collins LB, Laban G, Stapleton HM, Bickham JW, Swenberg JA, Di Giulio RT. 2011. Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia. Ecotoxicology 20:1890-1899. doi:10.1007/s10646-011-0727-9 PMID:21706406 PMCID:PMC3203518
  • Koturbash I, Scherhag A, Sexton K, Bodnar WM, Tryndyak VP, Swenberg JA, Beland FA, Pogribny IP, Rusyn I, Latendresse JR. 2011. Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-Butadiene. Environ Health Perspect 119:635-640. doi:10.1289/ehp.1002910
  • Lu K, Moeller BC, Doyle-Eisele M, McDonald JD, Swenberg JA. 2011. Molecular Dosimetry of N2-Hydroxymethyl-dG DNA Adducts in Rats Exposed to Formaldehyde. Chem Res Toxicol24(2):159-161. doi:10.1021/tx1003886
  • Luke AM, Chastain PD, Pachkowski BF, Afonin V, Takeda S, Kaufman DG, Swenberg JA, Nakamura J. 2011. Accumulation of true single strand breaks and AP sites in base excision repair deficient cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis694:65-71. doi:10.1016/j.mrfmmm.2010.08.008
  • Moeller BC, Lu K, Doyle-Eisele M, McDonald JD, Gigliotti A, Swenberg JA. 2011. Determination of N2-Hydroxymethyl-dG Adducts in the Nasal Epithelium and Bone Marrow of Nonhuman Primates Following 13CD2-Formaldehyde Inhalation Exposure. Chem Res Toxicol24(2):162-164. doi:10.1021/tx1004166
  • Ridpath JR, Takeda S, Swenberg JA, Nakamura J. 2011. Convenient, multi-well plate-based DNA damage response analysis using DT40 mutants is applicable to a high-throughput genotoxicity assay with characterization of modes of action. Environ Mol Mutagen52(2):153-160. doi:10.1002/em.20595
  • Swenberg JA, Lu K, Moeller BC, Gao L, Upton PB, Nakamura J, Starr TB. 2011. Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment. Toxicological Sciences120(suppl1):S130-S145. doi:10.1093/toxsci/kfq371
  • Wu K, Chiang S, Shih W, Huang CJ, Chen M, Swenberg JA. 2011. The application of mass spectrometry in molecular dosimetry: Ethylene oxide as an example. Mass Spectrom Rev30(5):733-756. doi:10.1002/mas.20299

2010

  • Asagoshi K, Tano K, Chastain PD, Adachi N, Sonoda E, Kikuchi K, Koyama H, Nagata K, Kaufman DG, Takeda S, Wilson SH, Watanabe M, Swenberg JA, Nakamura J. 2010. FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. Molecular Cancer Research8:204-15. doi:10.1158/1541-7786.MCR-09-0253
  • Boysen G, Collins LB, Liao S, Luke AM, Pachkowski BF, Watters JL, Swenberg JA. 2010. Analysis of 8-oxo-7,8-dihydro-2′-deoxyguanosine by ultra high pressure liquid chromatography–heat assisted electrospray ionization–tandem mass spectrometry. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences 878(3-4):375-380. doi:10.1016/j.jchromb.2009.12.004
  • Chastain PD, Nakamura J, Rao S, Chu H, Ibrahim J, Swenberg JA, Kaufman DG. 2010. Abasic sites preferentially form at regions undergoing DNA replication. FASEB Journal24(10):3674-80. doi:10.1096/fj.09-145276
  • Cowerd RB, Asmar MM, Alderman JM, Alderman EA, Garland AL, Busby WH, Bodnar WM, Rusyn I, Medoff BD, Tisch R, Swenberg JA, Zeisel S, Combs TP, Mayer-Davis E. 2010. Adiponectin lowers glucose production by increasing SOGA. American Journal of Pathology177(4):1936-1945. doi:10.2353/ajpath.2010.100363 PMID:20813965 PMCID:PMC2947288
  • Lu K, Collins LB, Ru H, Bermudez E, Swenberg JA. 2010. Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not Leukemia. Toxicological Sciences116(2):441-451. doi:10.1093/toxsci/kfq061
  • Lu K, Ye W, Zhou L, Collins LB, Chen X, Gold A, Ball LM, Swenberg JA. 2010. Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers. Journal of American Chemical Society 132(10):3388-3399. doi:10.1021/ja908282f
  • Mutlu E, Collins LB, Stout MD, Upton PB, Daye LR, Winsett D, Hatch G, Evansky P, Swenberg JA. 2010. Development and Application of an LC-MS/MS Method for the Detection of the Vinyl Chloride-Induced DNA Adduct N2,3-Ethenoguanine in Tissues of Adult and Weanling Rats Following Exposure to [13C2]-VC. Chem Res Toxicol23(9):1485-1491. doi:10.1021/tx1001767

2009

2008

2007

  • Brusick D, Small MS, Cavalieri EL, Chakravarti D, Ding X, Longfellow DG, Nakamura J, Rogan EC, Swenberg JA. 2007. Possible genotoxic modes of action for naphthalene. Regulatory Toxicology and Pharmacology
  • Kupper LL, Swenberg JA, Waiters JL, Satia JA, Schroeder JC. 2007. Associations of antioxidant nutrients and oxidative DNA damage in healthy African-American and White adults. Cancer Epidemiology Biomarkers & Prevention16(7):1428-36.
  • Ridpath JR, Nakamura J, Tano K, Luke AM, Sonoda E, Arakawa H, Buerstedde J, Gillespie DA, Sale JE, Yamazoe M, Bishop DK, Takata M, Takeda S, Watanabe M, Swenberg JA. 2007. Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. Cancer Res67(23):11117-22.

2006

  • Chastain PD, Nakamura J, Swenberg JA, Kaufman DG. 2006. Nonrandom AP site distribution in highly proliferative cells. FASEB Journal20(14):2612-4.
  • DeSimone MC, Harbourt D, Boysen G, Collins LB, Bradford BU, Han J, Swenberg JA, Threadgill DW, Rusyn I. 2006. Multi-strain study of trichoroethylene toxicity in mice. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.
  • Pachkowski BF, Winkel S, Kubota Y, Swenberg JA, Millikan RC, Nakamura J. 2006. XRCC1 genotype and breast cancer: Functional studies and epidemiologic data show interactions between XRCC1 codon 280 his and smoking. Cancer Res66(5):2860-2868.
  • Roper JC, Brown DM, Sullivan MA, Schoonhoven R, Swenberg JA, Pfaender FK. 2006. Epifluorescence microscopy and image analysis of high-level polycyclic aromatic hydrocarbon contamination in soils. Environmental Toxicology and Chemistry25(12):3093-100.

2005

  • Bammler TK, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li Y, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'Malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin L, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin J, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl HF. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2(5):351-6.
  • Jeong Y, Nakamura J, Upton PB, Swenberg JA. 2005. Pyrimido[1,2-a]-purin-10(3H)-one, M1G, is less prone to artifact than base oxidation. Nucleic Acids Res33(19):6426-6434.
  • Jeong Y, Sangaiah R, Nakamura J, Pachkowski BF, Ranasinghe A, Gold A, Ball LM, Swenberg JA. 2005. Analysis of M(1)G-dR in DNA by aldehyde reactive probe labeling and liquid chromatography tandem mass spectrometry. Chem Res Toxicol18(1):51-60.
  • Jeong Y, Swenberg JA. 2005. Formation of M1G-dR from endogenous and exogenous ROS-inducing chemicals. Free Radical Biology and Medicine39(8):1021-1029.
  • Lin C, Leow H, Huang S, Nakamura J, Swenberg JA, Lin P. 2005. Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells. Chem Res Toxicol18(2):257-264.
  • Weis BK, Balshaw DM, Barr JR, Brown D, Ellisman MH, Lioy PJ, Omenn G, Potter JD, Smith MT, Sohn L, Suk WA, Sumner S, Swenberg JA, Walt DR, Watkins S, Thompson CL, Wilson SH. 2005. Personalized exposure assessment: promising approaches for human environmental health research. Environ Health Perspect 113(7):840-8. doi:10.1289/ehp.7651 PMCID:PMC1257643

2004

  • Ham AL, Engelward BP, Koc H, Sangaiah R, Meira LB, Samson LD, Swenberg JA. 2004. New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N-6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo. DNA Repair (Amst)3(3):257-265.
  • Hu C, Wu M, Chao M, Pan C, Wang C, Swenberg JA, Wu K. 2004. Comparison of analyses of urinary 8-hydroxy-2 '-deoxyguanosine by isotope-dilution liquid chromatography with electrospray tandem mass spectrometry and by enzyme-linked immunosorbent assay. Rapid Communications in Mass Spectrometry18(4):505-510.
  • Lin P, Sangaiah R, Ranasinghe A, Ball LM, Swenberg JA, Gold A. 2004. Synthesis of chlorinated and non-chlorinated biphenyl-2,3-and 3,4-catechols and their [H-2(3)]-isotopomers. Org Biomol Chem2(18):2624-2629.
  • Rusyn I, Asakura S, Pachkowski BF, Bradford BU, Denissenko MF, Peters JM, Holland SM, Reddy JK, Cunningham ML, Swenberg JA. 2004. Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: Identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators. Cancer Res64(3):1050-1057.
  • Slikker W, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, David RM, Doerrer NG, Dorman DC, Gaylor DW, Hattis D, Rogers JM, Setzer RW, Swenberg JA, Wallace K, Andersen ME. 2004. Dose-dependent transitions in mechanisms of toxicity. Toxicol Appl Pharmacol201(3):203-225.
  • Swenberg JA. 2004. Toxicological considerations in the application and interpretation of DNA adducts in epidemiological studies. IARC Sci Publ 157:237-246.
  • Zielinska-Park J, Nakamura J, Swenberg JA, Aitken MD. 2004. Aldehydic DNA lesions in calf thymus DNA and HeLa S3 cells produced by bacterial quinone metabolites of fluoranthene and pyrene. Carcinogenesis25(9):1727-1733.

2003

  • Albertini R, Clewell H, Himmelstein MW, Morinello EJ, Olin S, Preston J, Scarano L, Smith MT, Swenberg JA, Tice RR, Travis C. 2003. The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene. Regulatory Toxicology and Pharmacology37(1):105-132.
  • Barbin A, Ohgaki H, Nakamura J, Kurrer M, Kleihues P, Swenberg JA. 2003. Endogenous deoxyribonucleic acid (DNA) damage in human tissues: A comparison of ethenobases with aldehydic DNA lesions. Cancer Epidemiology Biomarkers & Prevention12(11):1241-1247.
  • Horton JK, Joyce-Gray DF, Pachkowski BF, Swenberg JA, Wilson SH. 2003. Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. DNA Repair (Amst)2(1):27-48.
  • Li Y, Boysen G, Dicheva ND, Upton PB, Swenberg JA. 2003. Effects of Free Unmodified Purine Basis, Guanine and Adenine, on Ionization of Three N-7 Guanine DNA Adducts Using LC/ESI/MS/MS. In: Proceedings of the American Society of Mass Spectrometry, 51st Annual Conference.
  • Lin P, Nakamura J, Yamaguchi S, Asakura S, Swenberg JA. 2003. Aldehydic DNA lesions induced by catechol estrogens in calf thymus DNA. Carcinogenesis24(6):1133-1141.
  • Nakamura J, Asakura S, Hester SD, de Murcia G, Caldecott KW, Swenberg JA. 2003. Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time. Nucleic Acids Res31(17):e104.
  • Nakamura J, Purvis ER, Swenberg JA. 2003. Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells. Nucleic Acids Res31(6):1790-1795.
  • Nakamura J, Swenberg JA. 2003. Aldehyde Reactive Probe-Slot Blot Assay to quantitate DNA lesions caused by oxidative stress. In: Methods in Biological Oxidative Stress. Humana Press, pp.109-115.
  • Pachkowski BF, Nakamura J, Li Y, Sangaiah R, Gold A, Swenberg JA. 2003. An LC/MS Approach to the Differentiation of Aldehydic Deoxyribose Lesions. In: Proceedings of the American Association for Cancer Research Annual Meeting, 2003.
  • Williams DE, Bailey GS, Reddy A, Hendricks JD, Oganesian A, Orner GA, Pereira CB, Swenberg JA. 2003. The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters. Toxicol Pathol31(Suppl.1):58-61.

2002

  • Koc H, Swenberg JA. 2002. Applications of mass spectrometry for quantitation of DNA adducts. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences 778(1-2):323-343.
  • Lin P, La DK, Upton PB, Swenberg JA. 2002. Analysis of DNA adducts in rats exposed to pentachlorophenol. Carcinogenesis23(2):365-369.
  • Morinello EJ, Ham AL, Ranasinghe A, Nakamura J, Upton PB, Swenberg JA. 2002. Molecular dosimetry and repair of N2,3-ethenoguanine in rats exposed to vinyl chloride. Cancer Res62:5189-5195.
  • Morinello EJ, Koc H, Ranasinghe A, Swenberg JA. 2002. Differential induction of N2,3-ethenoguanine in rat brain and liver after exposure to vinyl chloride. Cancer Res62:5183-5188.
  • Sobol RW, Watson DE, Nakamura J, Yakes FM, Hou E, Horton JK, Wu J, Van Houten B, Swenberg JA, Tindall KR, Samson LD, Wilson SH. 2002. Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proceedings of the National Academy of Sciences of the United States of America (USA)99(14):6860-6865.
  • Swenberg JA. 2002. Toxicological considerations in the application and interpretation of DNA adducts in epidemiologic studies. IARC Sci Publ 157:237-246.
  • Swenberg JA, Georgieva NI, Ham AL, Koc H, Morinello EJ, Ranasinghe A, Upton PB, Walker V. 2002. Linking pharmacokinetics and biomarker data to mechanism of action in risk assessment. Human and Ecological Risk Assessment: An International Journal8(6):1315-1338.
  • Swenberg JA, Ham AL, Koc H, La DK, Morinello EJ, Pachkowski BF, Ranasinghe A, Upton PB. 2002. Methods for measuring DNA adducts and abasic sites II: Methods for measurement of DNA adducts. Current Protocols in Toxicology 3.9.1-3.9.35.
  • Swenberg JA, Ham AL, McDorman KS, Morinello EJ, Nakamura J, Schoonhoven R. 2002. Methods for measuring DNA adducts and abasic sites I: Isolation, purification, and analysis of DNA adducts in intact DNA. Current Protocols in Toxicology 3.8.1-3.8.18.
  • Toraason M, Andersen ME, Bogdanffy MS, Dankovic D, Faustman EM, Foster P, Frederick C, Haber L, Kimmel CA, Lewis S, McClellan R, Melnick R, Mirer F, Morgan K, Schaeffer V, Silbergeld EK, Slikker W, Swenberg JA, Vainio H. 2002. Improving risk assessment: Toxicological research needs. Human and Ecological Risk Assessment: An International Journal8(6):1405-1419.

2001

  • Ham AL, Zhan C, Koc H, Hass RJ, Swenberg JA. 2001. Analysis of 1,N6-ethenodeoxyguanosine by immunoaffinity/LC/MS/MS. In: Proceedings of the 49th ASMS (American Society for Mass Spectrometry) Conference on Mass Spectrometry and Allied Topics. June 4-7. Chicago, IL.
  • Lin P, Nakamura J, Yamaguchi S, La DK, Swenberg JA. 2001. Oxidative damage and direct adducts in calf thymus DNA induced by the pentachlorophenol metabolites, tetrachlorohydroquinone and tetrachloro-1,4-benzoquinone. Carcinogenesis22(4):627-634.
  • Lin P, Nakamura J, Yamaguchi S, La DK, Upton PB, Swenberg JA. 2001. Induction of direct adducts, apurinic/apyrimidinic sites, and oxidized bases in nuclear DNA of human HeLa S3 tumor cells by tetrachlorohydroquinone. Carcinogenesis22(4):635-639.
  • Morinello EJ, Ham AL, Ranasinghe A, Sangaiah R, Swenberg JA. 2001. Simultaneous quantitation of N2,3-ethenoguanine and 1,N2-ethenoguanine with immunoaffinity/gas chromatography/high resolution mass spectrometry. Chem Res Toxicol14:327-334.

2000

  • Boivin-Angele S, Lefrancois L, Froment O, Spiethoff A, Bogdanffy MS, Wegener K, Wesch H, Barbin A, Bancel B, Trepo C, Bartsch H, Swenberg JA, Marion M. 2000. Ras gene mutations in vinyl chloride-induced liver tumours are carcinogen-specific but vary with cell type and species. Int J Cancer85(2):223-227.
  • Ham AL, Ranasinghe A, Koc H, Swenberg JA. 2000. 4-Hydroxy-2-nonenal and ethyl linoleate from N2,3-ethenoguanine under peroxidizing conditions. Chem Res Toxicol13:1243-1250.
  • Hayes RB, Zhang L, Yin S, Swenberg JA, Xi L, Wiencke JK, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Zhang D, Wiemels JL, Dosemeci M, Li G, Smith MT. 2000. Genotoxic markers among butadiene-polymer workers in China. Carcinogenesis21(1):55-62.
  • Holt S, Roy G, Mitra SR, Upton PB, Bogdanffy MS, Swenberg JA. 2000. Deficiency of N-methylpurine-DNA-glycosylase expression in nonparenchymal cells, the target cell for vinyl chloride and vinyl fluoride. DNA Repair (Amst)460(2):105-115.
  • Lin P, Sangaiah R, Ranasinghe A, Upton PB, La DK, Gold A, Swenberg JA. 2000. Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2,2',5,5'-tetrachlorobiphenyl. Chem Res Toxicol13(8):710-718.
  • Nakamura J, La DK, Swenberg JA. 2000. 5'-Nicked Apurinic/Apyrimidinic Sites Are Resistant to b-Elimination by b-Polymerase and Are Persistent in Human Cultured Cells after Oxidative Stress. Journal of Biological Chemistry275(8):5323-5328.
  • Rusyn I, Denissenko MF, Wong VA, Butterworth BE, Cunningham ML, Upton PB, Thurman RG, Swenberg JA. 2000. Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency. Carcinogenesis21(12):2141-2145.
  • Swenberg JA, Christova-Gueoguieva NI, Upton PB, Ranasinghe A, Scheller NA, Wu K, Yen T, Hayes RB. 2000. Hemoglobin adducts as biomarkers of butadiene exposure and metabolism. HEI Research Report No. 92: 1,3-Butadiene and its metabolites: Interspecies comparison of carcinogenicity, mutagenicity and biomarkers. Part V. Hemoglobin adducts as biomarkers of butadiene exposure and metabolism pp.191-219.
  • Swenberg JA, Ham AL, Koc H, Morinello EJ, Ranasinghe A, Tretyakova N, Upton PB, Wu K. 2000. DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene. Mutation Research/Genetic Toxicology and Environmental Mutagenesis464(1):77-86. doi:10.1016/S1383-5718(99)00168-0
  • Walker V, Wu K, Upton PB, Ranasinghe A, Scheller NA, Cho M, Vergnes JS, Skopek TR, Swenberg JA. 2000. Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide. Carcinogenesis21(9):1661-1669.

1999

  • Ham AL, Ranasinghe A, Morinello EJ, Nakamura J, Upton PB, Johnson F, Swenberg JA. 1999. Immunoaffinity/gas chromatography/high resolution mass spectrometry method for the detection of N2,3-ethenoguanine. Chem Res Toxicol12:1240-1246.
  • Holt S, Bogdanffy MS, Swenberg JA. 1999. The molecular dosimetry and repair of vinyl fluoride-induced DNA adducts. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.335.
  • Ito N, La DK, Holt S, Craft TR, Sills RC, Swenberg JA. 1999. Analysis of ras mutations in forestomach tumors from B6C3F1 mice exposed to 1,2,3-trichloropropane. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.137.
  • La DK, Lin P, Swenberg JA. 1999. Analysis of DNA Adducts in rats chronically exposed to pentachlorophenol. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.330.
  • La DK, Swenberg JA. 1999. The induction of endogenous DNA adducts in tissues of Fischer-344 rats following gavage administration of 1,2,3-trichloropropane. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.131.
  • Lin P, Sangaiah R, Swenberg JA. 1999. Adducts of 2,3,2',5'-tetrachlorobiphenyl-derived ortho-quinone with rat liver proteins after metabolic activation in vitro. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.330.
  • Lin P, Waidyanatha S, Pollack GM, Swenberg JA, Rappaport SM. 1999. Dose-specific production of chlorinated quinone and semiquinone adducts in rodent livers following administration of pentachlorophenol. Toxicological Sciences47(1):126-133.
  • Mitro KL, Scheller NA, Ranasinghe A, Swenberg JA. 1999. Quantitation of endogenous N2,3-ethenoguanine in human and rat liver DNA using high resolution mass spectrometry. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.847.
  • Nakamura J, Swenberg JA. 1999. Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues. Cancer Res59(11):2522-2526.
  • Nakamura J, Walker V, Upton PB, Swenberg JA. 1999. Characterization of a newly developed AP site assay that uses an aldehyde reactive probe-Slot-Blot method. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.480.
  • Swenberg JA, Bogdanffy MS, Ham AL, Holt S, Kim AH, Morinello EJ, Ranasinghe A, Scheller NA, Upton PB. 1999. Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride- induced carcinogenesis. IARC Sci Publ 150:29-43.
  • Swenberg JA, Lehman-McKeeman LD. 1999. Urinary globulin-associated nephropathy as a mechanism of renal tubular cell carcinogenesis in male rats. IARC Sci Publ 147:95-118.
  • Wu K, Ranasinghe A, Upton PB, Scheller NA, Swenberg JA. 1999. Endogenous formation of the major DNA adduct of ethylene oxide in humans, rats, and mice. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.102.
  • Wu K, Ranasinghe A, Upton PB, Walker V, Swenberg JA. 1999. Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl)guanine formation in tissues of rodents. Carcinogenesis20:1787-1792.
  • Wu K, Scheller NA, Cho M, Ranasinghe A, Upton PB, Walker V, Swenberg JA. 1999. Molecular dosimetry of hydroxyethyl adducts in DNA and hemoglobin following exposure of rats and mice to ethylene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.839.
  • Wu K, Scheller NA, Ranasinghe A, Yen T, Sangaiah R, Giese RW, Swenberg JA. 1999. A gas chromatography/electron capture/negative chemical ionization-high resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring. Chem Res Toxicol12(8):722-729.

1998

  • Ham AL, Swenberg JA. 1998. Immunoaffinity (IA) gas chromatography/mass spectometry (GC/MS) method for N2,3-ethenoguanine demonstrates importance of hydrolysis method for adduct quantitation. Fundamental and Applied Toxicology42:180.
  • Holt S, Sangaiah R, Swenberg JA. 1998. Detection of 1,N6-Ethenoadenine in Rat Urine After Chloroethylene Oxide Exposure. Carcinogenesis19(10):1763-1769.
  • Holt S, Scheller NA, Mitra SR, Bogdanffy MS, Swenberg JA. 1998. Formation and repair of vinyl fluoride-induced DNA adducts. Fundamental and Applied Toxicology42:180.
  • Law JM, Bull M, Nakamura J, Swenberg JA. 1998. Molecular dosimetry of DNA adducts in the medaka small fish model. Carcinogenesis19(3):515-518.
  • Nakamura J, Walker V, Upton PB, Chiang S, Kow YW, Swenberg JA. 1998. Highly sensitive AP site assay can detect spontaneous and chemically-induced depurination under physiological conditions. Cancer Res58(2):222-225.
  • Ploch SA, Nakamura J, Swenberg JA, Di Giulio RT. 1998. Assessment of AP site formation in isolated hepatocytes from brown bullhead upon treatment with benzo(a)pyrene. Fundamental and Applied Toxicology42:82.
  • Ranasinghe A, Ham AL, Morinello EJ, Swenberg JA. 1998. Quantitation of 1, N2-ethenoguanine and N2, 3-ethenoguanine by IAC/GC/ECNCI/HRMS. In: Proceedings of the 46th ASMS (American Society for Mass Spectrometry) Conference on Mass Spectrometry and Allied Topics.
  • Ranasinghe A, Scheller NA, Wu K, Upton PB, Swenberg JA. 1998. Application of Gas Chromatography/Electron Capture Negative Chemical Ionization/High Resolution Mass spectrometry for Analysis of DNA and Protein Adducts. Chem Res Toxicol11:520-526.
  • Yen T, Holt S, Sangaiah R, Gold A, Swenberg JA. 1998. Quantitation of 1,N6 Ethenoadenine in Rat Urine by Immunoaffinity Extraction Combined with Liquid Chromatography/Electrospray Ionization Mass Spectrometry. Chem Res Toxicol11(7):810-815.

1997

  • La DK, Swenberg JA. 1997. Carcinogenic alkylating agents. In: Comprehensive Toxicology, Vol. 12, Chemical Carcinogens and Anticarcinogens. Elsevier Science, Oxford, United Kingdom. pp.111-140.
  • Scheller NA, Ranasinghe A, Bogdanffy MS, Swenberg JA. 1997. Detection of N2,3-ethenoguanine by GC/HR-MS in brains and kidneys in vinyl fluoride exposed rodents. Fundamental and Applied Toxicology36:94.
  • Swenberg JA. 1997. Generating data for scientifically-based risk assessment. Fundamental and Applied Toxicology36:286.
  • Swenberg JA. 1997. In vivo studies on the formation and repair of DNA adducts. In: Proceedings of Environmental Mutagen Society Meeting, 1997. Minneapolis, MN.
  • Wu K, Ranasinghe A, Scheller NA, Upton PB, Swenberg JA. 1997. Mechanism-based risk assessment: Utility of DNA adducts in model selection. Fundamental and Applied Toxicology36:97.
  • Yen T, Wu K, Holt S, Sangaiah R, Swenberg JA. 1997. Determination of DNA adducts from ethylene oxide and vinyl chloride exposure. In: Proceedings of the 45th AMS (American Society of Microbiology) Conference on Mass Spectrometry and Allied Topics. pp.295.

1996

  • Chiang S, Swenberg JA, Weisman WA, Skopek TR. 1996. Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line. Carcinogenesis18(1):31-36.
  • Christova-Gueoguieva NI, Yen T, Scheller NA, Holt S, Swenberg JA. 1996. Quantitation of N2,3-ethenoguanine (εG) in rat liver by liquid chromatography-electrospray mass spectrometry. The Toxicologist30(1,part2):235.
  • Holt S, Swenberg JA. 1996. Age-dependent modulation of tissue-specific repair activity for methylpurine glycosylase. The Toxicologist30(1,part2):236.
  • La DK, Schoonhoven R, Ito N, Swenberg JA. 1996. The effects of exposure route on DNA adduct formation and cellular proliferation by 1,2,3-trichloropropane. Toxicol Appl Pharmacol140(1):108-114.
  • La DK, Swenberg JA, Ham AL, Koc H, Morinello EJ, Ranasinghe A, Tretyakova N, Upton PB, Wu K. 1996. DNA adducts: Biological markers of exposure and potential applications to risk assessment. Mutat Res365:129-146.
  • Ranasinghe A, Scheller NA, Wu K, Swenberg JA. 1996. GC/ECNCI/MS/MS Analysis of electrophore-labeled DNA adducts. In: Proceedings of the 44th ASMS (American Society for Mass Spectrometry) on Mass Spectrometry and Allied Topics. Portland, OR.
  • Scheller NA, Ranasinghe A, Christova-Gueoguieva NI, Yen T, Ham AL, Swenberg JA. 1996. Detection of Endogenous N2,3-ethenoguanine by GC/ECNCI/MS. In: Proceedings of the 44th ASMS (American Society for Mass Spectrometry) on Mass Spectrometry and Allied Topics. Portland, OR. pp.781.
  • Swenberg JA, La DK, Scheller NA, Wu K. 1996. Dose-response relationships for carcinogens. Toxicol Lett82-3:751-756.
  • Swenberg JA, Scheller NA, Ranasinghe A, Upton PB, Christova-Gueoguieva NI, Bogdanffy MS. 1996. Molecular dosimetry of N2,3-ethenoguanine in DNA of vinyl fluoride-exposed rats: Relationship to hemangiosarcoma. The Toxicologist30(1,part2):235.
  • Yen T, Christova-Gueoguieva NI, Scheller NA, Holt S, Swenberg JA, Charles MJ. 1996. HPLC/ESI/MS May be the Technique of Choice for the Analysis of Certain DNA Adducts. In: Proceedings of the 44th ASMS (American Society for Mass Spectrometry) on Mass Spectrometry and Allied Topics. Portland, OR. pp.780.
  • Yen T, Christova-Gueoguieva NI, Scheller NA, Holt S, Swenberg JA, Charles MJ. 1996. Quantitative analysis of the DNA N2,3-Ethenoguanine using liquid chromatography/electrospray ionization mass spectrometry. Journal of Mass Spectrometry31(11):1271-1276.

1995

  • Chiang S, Craft TR, Skopek TR, Swenberg JA. 1995. Mutation spectra of vinyl chloride (VC) and chloroethylene oxide (CEO) at the hprt gene in metabolically-competent human lymphoblastoid lines. International Toxicologist 7(1):46P9.
  • Chiang S, Skopek TR, Swenberg JA. 1995. Mutagenicity of vinyl chloride and its metabolites, and vinyl fluoride in a metabolically competent human lymphoblastoid line. The Toxicologist15(1):79.
  • Holt S, Swenberg JA. 1995. Detection of 1,N6-ethenoadenine excreted in rat urine after chloroethylene oxide exposure. The Toxicologist15(1):77.
  • Scheller NA, Ranasinghe A, Kim AH, Holt S, Bogdanffy MS, Swenberg JA. 1995. High resolution GC/MS detection of N2,3-ethenoguanine in livers of control and vinyl fluoride-exposed B6C3F1 mice. International Toxicologist 7(1):6P21.
  • Scheller NA, Sangaiah R, Ranasinghe A, Amarnath V, Gold A, Swenberg JA. 1995. Synthesis of [4,5,6,8-13C4]guanine, a reagent for the production of internal standards of guanyl DNA adducts. Chem Res Toxicol8(3):333-337.
  • Swenberg JA. 1995. Bioassay design and MTD setting: Old methods and new approaches. Regulatory Toxicology and Pharmacology21:44-51.
  • Swenberg JA. 1995. Carcinogenesis. In: Patty's Industrial Hygiene and Toxicology, 3rd edition, Volume 4, Part B. Wiley and Sons, New York, NY. pp.255-273.
  • Yen T, Christova-Gueoguieva NI, Scheller NA, Swenberg JA, Charles MJ. 1995. Quantitative analysis of DNA adducts by using HPLC/ESI-MS. In: Proceedings of the 43rd ASMS (American Society for Mass Spectrometry) Conference on Mass Spectrometry and Allied Topics. pp.497.

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