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Person Details: James A. Swenberg

Superfund Research Program

James A. Swenberg

University of North Carolina-Chapel Hill
Department of Environmental Sciences and Engineering
253C Rosenau Hall, CB# 7431
Chapel Hill, North Carolina 27599-7431
Phone: 919-966-6139
Fax: 919-966-6123


Research Briefs


Hazardous Waste Sites

Ciba-Giegy Corp. Site

  • University of North Carolina-Chapel Hill: Biomarkers of Exposure versus Effect: Improving the Scientific Basis for Risk Assessment

Hudson River PCBs

  • University of North Carolina-Chapel Hill: Biomarkers of Exposure versus Effect: Improving the Scientific Basis for Risk Assessment



  • De La Rosa VY, Asfaha J, Fasullo M, Loguinov AV, Li P, Moore LE, Rothman N, Nakamura J, Swenberg JA, Scelo G, Zhang L, Smith MT, Vulpe CD. 2017. Editor's highlight: High-throughput functional genomics identifies modulators of TCE metabolite genotoxicity and candidate susceptibility genes. Toxicol Sci 160:111-120. doi:10.1093/toxsci/kfx159 PMID:28973557 PMCID:PMC5837773
  • Edrissi B, Taghizadeh K, Moeller BC, Yu R, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC. 2017. N6-Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N6-Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats. Chem Res Toxicol 30(8):1572-1576. doi:10.1021/acs.chemrestox.7b00075 PMID:28692800 PMCID:PMC5807069
  • Gao L, Mutlu E, Collins LB, Walker N, Hartwell HJ, Olson J, Sun W, Gold A, Ball LM, Swenberg JA. 2017. DNA product formation in female Sprague-Dawley rats following polyhalogenated aromatic hydrocarbon (PHAH) exposure. Chem Res Toxicol 30(3):794-803. doi:10.1021/acs.chemrestox.6b00368 PMID:28207250 PMCID:PMC5363288
  • Klaus V, Bastek H, Damme K, Collins LB, Frotschl R, Benda N, Lutter D, Ellinger-Ziegelbauer H, Swenberg JA, Dietrich DR, Stemmer K. 2017. Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats. Arch Toxicol 91(10):3427-3438. doi:10.1007/s00204-017-1953-6 PMID:28349193 PMCID:PMC5617782


  • Hashimoto K, Sharma V, Sasanuma H, Tian X, Takata M, Takeda S, Swenberg JA, Nakamura J. 2016. Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells. Oncotarget 7(37):59795-59808. doi:10.18632/oncotarget.10928 PMID:27486975
  • Lai Y, Yu R, Hartwell HJ, Moeller BC, Bodnar WM, Swenberg JA. 2016. Measurement of endogenous versus exogenous formaldehyde-induced DNA-protein crosslinks in animal tissues by stable isotope labeling and ultrasensitive mass spectrometry. Cancer Res 76(9):2652-2661. doi:10.1158/0008-5472.CAN-15-2527 PMID:26984759 PMCID:PMC4879886
  • Mutlu E, Gao L, Collins LB, Walker N, Hartwell HJ, Olson J, Sun W, Gold A, Ball LM, Swenberg JA. 2016. Polychlorinated biphenyls induce oxidative DNA adducts in female Sprague-Dawley rats. Chem Res Toxicol 29(8):1335-1344. doi:10.1021/acs.chemrestox.6b00146 PMID:27436759 PMCID:PMC5020703
  • Sharma V, Collins LB, Chen T, Herr N, Takeda S, Sun W, Swenberg JA, Nakamura J. 2016. Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations. Oncotarget 7(18):25377-25390. doi:10.18632/oncotarget.8298 PMID:27015367 PMCID:PMC5041911
  • Swenberg JA, Lai Y, Yu R, Sharma V, Moeller BC, Hartwell HJ, MacDonald Gibson J, Nakamura J. 2016. The role of endogenous versus exogenous DNA damage in risk assessment. In: Thresholds of genotoxic carcinogens: from mechanisms to regulation. Elsevier, pp.83-102.
  • Tian X, Patel K, Ridpath JR, Chen Y, Zhou Y, Neo D, Clement JM, Takata M, Takeda S, Sale J, Wright FA, Swenberg JA, Nakamura J. 2016. Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium. PLoS One 11(12):e0167503. doi:10.1371/journal.pone.0167503 PMID:27907204 PMCID:PMC5132242
  • Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, Liu Y, Byrum SD, Mackintosh SG, Zhong M, Tackett A, Wang G, Hon LS, Fang G, Swenberg JA, Xiao AZ. 2016. DNA methylation on N(6)-adenine in mammalian embryonic stem cells. Nature 532(7599):329-333. doi:10.1038/nature17640 PMID:27027282 PMCID:PMC4977844


  • Hashimoto K, Takeda S, Swenberg JA, Nakamura J. 2015. Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells. Mutagenesis 30(6):821-828. doi:10.1093/mutage/gev042 PMID:26085549 PMCID:PMC4723676
  • Pontel LB, Rosado IV, Burgos-Barragan G, Arends MJ, Chandrasekaran G, Broecker V, Liu L, Swenberg JA, Crossan GP, Patel KJ. 2015. Endogenous formaldehyde is a hematopoietic stem cell genotoxin and metabolic carcinogen. Mol Cell 60(1):177-188. doi:10.1016/j.molcel.2015.08.020 PMID:26412304 PMCID:PMC4595711
  • Yu R, Lai Y, Hartwell HJ, Moeller BC, Doyle-Eisele M, Bodnar WM, Starr TB, Swenberg JA. 2015. Formation, accumulation, and hydrolysis of endogenous and exogenous formaldehyde-induced DNA damage. Toxicol Sci 146(1):170-182. doi:10.1093/toxsci/kfv079 PMID:25904104 PMCID:PMC4476463


  • Nakamura J, Mutlu E, Sharma V, Collins LB, Bodnar WM, Yu R, Lai Y, Moeller BC, Lu K, Swenberg JA. 2014. The endogenous exposome. DNA Repair (Amst) 19:3-13. doi:10.1016/j.dnarep.2014.03.031 PMID:24767943 PMCID:PMC4097170
  • Pottenger LH, Andrews LS, Bachman AN, Boogaard PJ, Cadet J, Embry MR, Farmer PB, Himmelstein MW, Jarabek AM, Martin EA, Mauthe RJ, Persaud R, Preston J, Schoeny R, Skare J, Swenberg JA, Williams GM, Zeiger E, Zhang F, Kim JH. 2014. An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride. Crit Rev Toxicol 44(4):348-391. doi:10.3109/10408444.2013.873768 PMID:24494825
  • Rager JE, Moeller BC, Miller SK, Kracko D, Doyle-Eisele M, Swenberg JA, Fry RC. 2014. Formaldehyde-associated changes in microRNAs: tissue and temporal specificity in the rat nose, white blood cells, and bone marrow. Toxicol Sci 138(1):36-46. doi:10.1093/toxsci/kft267 PMID:24304932 PMCID:PMC3930361
  • Sharma V, Collins LB, Clement JM, Zhang Z, Nakamura J, Swenberg JA. 2014. Molecular dosimetry of endogenous and exogenous O(6)-methyl-dG and N7-methyl-G adducts following low dose [D3]-methylnitrosourea exposures in cultured human cells. Chem Res Toxicol 27(4):480-482. doi:10.1021/tx5000602 PMID:24628573 PMCID:PMC3998766
  • Shibutani T, Ito S, Toda M, Kanao R, Collins LB, Shibata M, Urabe M, Koseki H, Masuda Y, Swenberg JA, Masutani C, Hanaoka F, Iwai S, Kuraoka I. 2014. Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication. Sci Rep 4:5220. doi:10.1038/srep05220 PMID:24910358 PMCID:PMC4048885


  • Edrissi B, Taghizadeh K, Moeller BC, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC. 2013. Dosimetry of n(6)-formyllysine adducts following [(13)c(2)h2]-formaldehyde exposures in rats. Chem Res Toxicol 26(10):1421-1423. doi:10.1021/tx400320u PMID:24087891 PMCID:PMC3805309
  • Moeller BC, Recio L, Green A, Sun W, Wright FA, Bodnar WM, Swenberg JA. 2013. Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure. Toxicol Sci 133(1):1-12. doi:10.1093/toxsci/kft029 PMID:23425604 PMCID:PMC3627555
  • Rager JE, Moeller BC, Doyle-Eisele M, Kracko D, Swenberg JA, Fry RC. 2013. Formaldehyde and epigenetic alterations: microRNA changes in the nasal epithelium of nonhuman primates. Environ Health Perspect 121(3):339-344. doi:10.1289/ehp.1205582 PMID:23322811 PMCID:PMC3621188
  • Starr TB, Swenberg JA. 2013. A novel bottom-up approach to bounding low-dose human cancer risks from chemical exposures. Regul Toxicol Pharmacol 65(3):311-315. doi:10.1016/j.yrtph.2013.01.004 PMID:23352840
  • Swenberg JA, Moeller BC, Lu K, Rager JE, Fry RC, Starr TB. 2013. Formaldehyde carcinogenicity research: 30 years and counting for mode of action, epidemiology, and cancer risk assessment. Toxicol Pathol 41(2):181-189. doi:10.1177/0192623312466459 PMID:23160431 PMCID:PMC3893912


  • Lu K, Craft S, Nakamura J, Moeller BC, Swenberg JA. 2012. Use of LC-MS/MS and stable isotopes to differentiate hydroxymethyl and methyl DNA adducts from formaldehyde and nitrosodimethylamine. Chem Res Toxicol 25(3):664-675. doi:10.1021/tx200426b PMID:22148432 PMCID:PMC3307879
  • Lu K, Gul H, Upton PB, Moeller BC, Swenberg JA. 2012. Formation of hydroxymethyl DNA adducts in rats orally exposed to stable isotope labeled methanol. Toxicol Sci 126(1):28-38. doi:10.1093/toxsci/kfr328 PMID:22157354 PMCID:PMC3289495
  • Mutlu E, Jeong Y, Collins LB, Ham AL, Upton PB, Hatch G, Winsett D, Evansky P, Swenberg JA. 2012. A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-oxoethyl)guanine in Sprague–Dawley rats. Chem Res Toxicol 25(2):391-399. doi:10.1021/tx200447w PMID:22211352 PMCID:PMC3288741
  • Nakamura J, Gul H, Tian X, Bultman SJ, Swenberg JA. 2012. Detection of PIGO-deficient cells using proaerolysin: a valuable tool to investigate mechanisms of mutagenesis in the DT40 cell system. PLoS One 7(3):e33563. doi:10.1371/journal.pone.0033563 PMID:22428069 PMCID:PMC3299801


  • Adami H, Berry CL, Breckenridge CB, Smith LL, Swenberg JA, Trichopoulos D, Weiss NS, Pastoor TP. 2011. Toxicology and epidemiology: improving the science with a framework for combining toxicological and epidemiological evidence to establish causal inference. Toxicol Sci 122(2):223-234. doi:10.1093/toxsci/kfr113 PMID:21561883 PMCID:PMC3155086
  • Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y. 2011. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333(6047):1300-1303. doi:10.1126/science.1210597 PMID:21778364 PMCID:PMC3495246
  • Jung D, Matson CW, Collins LB, Laban G, Stapleton HM, Bickham JW, Swenberg JA, Di Giulio RT. 2011. Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia. Ecotoxicology 20:1890-1899. doi:10.1007/s10646-011-0727-9 PMID:21706406 PMCID:PMC3203518
  • Koturbash I, Scherhag A, Sexton K, Bodnar WM, Tryndyak VP, Swenberg JA, Beland FA, Pogribny IP, Rusyn I, Latendresse JR. 2011. Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-Butadiene. Environ Health Perspect 119:635-640. doi:10.1289/ehp.1002910 PMID:21147608 PMCID:PMC3094413
  • Lu K, Moeller BC, Doyle-Eisele M, McDonald JD, Swenberg JA. 2011. Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde. Chem Res Toxicol 24(2):159-161. doi:10.1021/tx1003886 PMID:21155545 PMCID:PMC3128468
  • Luke AM, Chastain PD, Pachkowski BF, Afonin V, Takeda S, Kaufman DG, Swenberg JA, Nakamura J. 2011. Accumulation of true single strand breaks and AP sites in base excision repair deficient cells. Mutat Res 694:65-71. doi:10.1016/j.mrfmmm.2010.08.008 PMID:20851134 PMCID:PMC2992575
  • Moeller BC, Lu K, Doyle-Eisele M, McDonald JD, Gigliotti A, Swenberg JA. 2011. Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure. Chem Res Toxicol 24(2):162-164. doi:10.1021/tx1004166 PMID:21222454 PMCID:PMC3273041
  • Ridpath JR, Takeda S, Swenberg JA, Nakamura J. 2011. Convenient, multi-well plate-based DNA damage response analysis using DT40 mutants is applicable to a high-throughput genotoxicity assay with characterization of modes of action. Environ Mol Mutagen 52(2):153-160. doi:10.1002/em.20595 PMID:20839229 PMCID:PMC3280086
  • Swenberg JA, Lu K, Moeller BC, Gao L, Upton PB, Nakamura J, Starr TB. 2011. Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment. Toxicol Sci 120(suppl1):S130-S145. doi:10.1093/toxsci/kfq371 PMID:21163908 PMCID:PMC3043087
  • Wu K, Chiang S, Shih W, Huang CJ, Chen M, Swenberg JA. 2011. The application of mass spectrometry in molecular dosimetry: Ethylene oxide as an example. Mass Spectrom Rev 30(5):733-756. doi:10.1002/mas.20299 PMID:21328599


  • Asagoshi K, Tano K, Chastain PD, Adachi N, Sonoda E, Kikuchi K, Koyama H, Nagata K, Kaufman DG, Takeda S, Wilson SH, Watanabe M, Swenberg JA, Nakamura J. 2010. FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. Mol Cancer Res 8(2):204-215. doi:10.1158/1541-7786.MCR-09-0253 PMID:20145043 PMCID:PMC2824787
  • Boysen G, Collins LB, Liao S, Luke AM, Pachkowski BF, Watters JL, Swenberg JA. 2010. Analysis of 8-oxo-7,8-dihydro-2′-deoxyguanosine by ultra high pressure liquid chromatography–heat assisted electrospray ionization–tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 878(3-4):375-380. doi:10.1016/j.jchromb.2009.12.004 PMID:20022307 PMCID:PMC5085061
  • Chastain PD, Nakamura J, Rao S, Chu H, Ibrahim J, Swenberg JA, Kaufman DG. 2010. Abasic sites preferentially form at regions undergoing DNA replication. FASEB J 24(10):3674-80. doi:10.1096/fj.09-145276 PMID:20511393 PMCID:PMC2996904
  • Cowerd RB, Asmar MM, Alderman JM, Alderman EA, Garland AL, Busby WH, Bodnar WM, Rusyn I, Medoff BD, Tisch R, Swenberg JA, Zeisel S, Combs TP, Mayer-Davis E. 2010. Adiponectin lowers glucose production by increasing SOGA. Am J Pathol 177(4):1936-1945. doi:10.2353/ajpath.2010.100363 PMID:20813965 PMCID:PMC2947288
  • Lu K, Collins LB, Ru H, Bermudez E, Swenberg JA. 2010. Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not Leukemia. Toxicol Sci 116(2):441-451. doi:10.1093/toxsci/kfq061 PMID:20176625 PMCID:PMC2905397
  • Lu K, Ye W, Zhou L, Collins LB, Chen X, Gold A, Ball LM, Swenberg JA. 2010. Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers. J Am Chem Soc 132(10):3388-3399. doi:10.1021/ja908282f PMID:20178313 PMCID:PMC2866014
  • Mutlu E, Collins LB, Stout MD, Upton PB, Daye LR, Winsett D, Hatch G, Evansky P, Swenberg JA. 2010. Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N2,3-ethenoguanine in tissues of adult and weanling rats following exposure to [13C2]-VC. Chem Res Toxicol 23(9):1485-1491. doi:10.1021/tx1001767 PMID:20799743 PMCID:PMC3104734


  • Bordeerat NK, Georgieva NI, Klapper DG, Collins LB, Cross TJ, Borchers CH, Swenberg JA, Boysen G. 2009. Accurate quantitation of standard peptides used for quantitative proteomics. Proteomics 9(15):3939-3944. doi:10.1002/pmic.200900043 PMID:19637239 PMCID:PMC2766299
  • Boysen G, Pachkowski BF, Nakamura J, Swenberg JA. 2009. The formation and biological significance of N7-guanine adducts. Mutat Res 678(2):76-94. doi:10.1016/j.mrgentox.2009.05.006 PMID:19465146 PMCID:PMC2739241
  • Jung D, Cho Y, Collins LB, Swenberg JA, Di Giulio RT. 2009. Effects of benzo[a]pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site. Aquat Toxicol 95(1):44-51. doi:10.1016/j.aquatox.2009.08.003 PMID:19726093 PMCID:PMC2776085
  • Kim S, Boysen G, Swenberg JA, Gold A, Ball LM, Bradford BU, Rusyn I, Collins LB. 2009. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology 262(3):230-238. doi:10.1016/j.tox.2009.06.013 PMID:19549554 PMCID:PMC2765814
  • Pachkowski BF, Tano K, Afonin V, Elder RH, Takeda S, Watanabe M, Swenberg JA, Nakamura J. 2009. Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS. Mutat Res 671(1-2):93-99. doi:10.1016/j.mrfmmm.2009.09.006 PMID:19778542 PMCID:PMC2784157
  • Swenberg JA, Starr TB, Albertini R, Walker V. 2009. Response to Keshava et al. Chem Res Toxicol 22(1):10-12. doi:10.1021/tx800438g
  • Ye W, Gold A, Ball LM, Swenberg JA, Lu K. 2009. Formation of S-[1-(N2-deoxyguanosinyl)methyl]glutathione between glutathione and DNA induced by formaldehyde. J Am Chem Soc 131(10):3414-3415. doi:10.1021/ja808048c PMID:19239220 PMCID:PMC3277947


  • Brusick D, Small MS, Cavalieri EL, Chakravarti D, Ding X, Longfellow DG, Nakamura J, Rogan EC, Swenberg JA. 2008. Possible genotoxic modes of action for naphthalene. Regul Toxicol Pharmacol 51(2Suppl):S43-S50. doi:10.1016/j.yrtph.2007.12.002 PMID:18194829
  • Jeong Y, Walker NJ, Burgin DE, Kissling G, Gupta M, Kupper LL, Birnbaum LS, Swenberg JA. 2008. Accumulation of M1dG DNA adducts after chronic exposure to PCBs, but not from acute exposure to polychlorinated aromatic hydrocarbons. Free Radic Biol Med 45(5):585-591. doi:10.1016/j.freeradbiomed.2008.04.043 PMID:18534201 PMCID:PMC2570591
  • Lu K, Boysen G, Swenberg JA, Gao L, Collins LB. 2008. Formaldehyde-induced histone modifications in vitro. Chem Res Toxicol 21(8):1586-1593. doi:10.1021/tx8000576 PMID:18656964
  • Swenberg JA, Fryar-Tita E, Jeong Y, Boysen G, Starr TB, Walker V, Albertini R. 2008. Biomarkers in toxicology and risk assessment: informing critical dose-response relationships. Chem Res Toxicol 21(1):253-265. doi:10.1021/tx700408t PMID:18161944


  • Kupper LL, Swenberg JA, Waiters JL, Satia JA, Schroeder JC. 2007. Associations of antioxidant nutrients and oxidative DNA damage in healthy African-American and White adults. Cancer Epidemiol Biomarkers Prev 16(7):1428-1436. doi:10.1158/1055-9965.EPI-06-1030 PMID:17627008
  • Ridpath JR, Nakamura J, Tano K, Luke AM, Sonoda E, Arakawa H, Buerstedde J, Gillespie DA, Sale JE, Yamazoe M, Bishop DK, Takata M, Takeda S, Watanabe M, Swenberg JA. 2007. Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. Cancer Res 67(23):11117-11122. doi:10.1158/0008-5472.CAN-07-3028 PMID:18056434


  • Chastain PD, Nakamura J, Swenberg JA, Kaufman DG. 2006. Nonrandom AP site distribution in highly proliferative cells. FASEB J 20(14):2612-4. PMID:17068113
  • DeSimone MC, Harbourt D, Boysen G, Collins LB, Bradford BU, Han J, Swenberg JA, Threadgill DW, Rusyn I. 2006. Multi-strain study of trichoroethylene toxicity in mice. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.
  • Pachkowski BF, Winkel S, Kubota Y, Swenberg JA, Millikan RC, Nakamura J. 2006. XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking. Cancer Res 66(5):2860-2868. doi:10.1158/0008-5472.CAN-05-3388 PMID:16510609
  • Roper JC, Brown DM, Sullivan MA, Schoonhoven R, Swenberg JA, Pfaender FK. 2006. Epifluorescence microscopy and image analysis of high-level polycyclic aromatic hydrocarbon contamination in soils. Environ Toxicol Chem 25(12):3093-100. PMID:17220076


  • Bammler TK, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li Y, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'Malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin L, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin J, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl HF. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2(5):351-6. PMID:15846362
  • Jeong Y, Nakamura J, Upton PB, Swenberg JA. 2005. Pyrimido[1,2-a]-purin-10(3H)-one, M1G, is less prone to artifact than base oxidation. Nucleic Acids Res 33(19):6426-6434. doi:10.1093/nar/gki944 PMID:16282591 PMCID:PMC1283527
  • Jeong Y, Sangaiah R, Nakamura J, Pachkowski BF, Ranasinghe A, Gold A, Ball LM, Swenberg JA. 2005. Analysis of M(1)G-dR in DNA by aldehyde reactive probe labeling and liquid chromatography tandem mass spectrometry. Chem Res Toxicol 18(1):51-60. PMID:15651849
  • Jeong Y, Swenberg JA. 2005. Formation of M1G-dR from endogenous and exogenous ROS-inducing chemicals. Free Radic Biol Med 39(8):1021-1029. PMID:16198229
  • Lin C, Leow H, Huang S, Nakamura J, Swenberg JA, Lin P. 2005. Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells. Chem Res Toxicol 18(2):257-264. PMID:15720130
  • Weis BK, Balshaw DM, Barr JR, Brown D, Ellisman MH, Lioy PJ, Omenn G, Potter JD, Smith MT, Sohn L, Suk WA, Sumner S, Swenberg JA, Walt DR, Watkins S, Thompson CL, Wilson SH. 2005. Personalized exposure assessment: promising approaches for human environmental health research. Environ Health Perspect 113(7):840-848. PMID:16002370 PMCID:PMC1257643


  • Ham AL, Engelward BP, Koc H, Sangaiah R, Meira LB, Samson LD, Swenberg JA. 2004. New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N-6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo. DNA Repair (Amst) 3(3):257-265. PMID:15177041
  • Hu C, Wu M, Chao M, Pan C, Wang C, Swenberg JA, Wu K. 2004. Comparison of analyses of urinary 8-hydroxy-2 '-deoxyguanosine by isotope-dilution liquid chromatography with electrospray tandem mass spectrometry and by enzyme-linked immunosorbent assay. Rapid Commun Mass Spectrom 18(4):505-510. PMID:14966860
  • Lin P, Sangaiah R, Ranasinghe A, Ball LM, Swenberg JA, Gold A. 2004. Synthesis of chlorinated and non-chlorinated biphenyl-2,3-and 3,4-catechols and their [H-2(3)]-isotopomers. Org Biomol Chem 2(18):2624-2629. PMID:15351827
  • Rusyn I, Asakura S, Pachkowski BF, Bradford BU, Denissenko MF, Peters JM, Holland SM, Reddy JK, Cunningham ML, Swenberg JA. 2004. Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: Identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators. Cancer Res 64(3):1050-1057. PMID:14871837
  • Slikker W, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, David RM, Doerrer NG, Dorman DC, Gaylor DW, Hattis D, Rogers JM, Setzer RW, Swenberg JA, Wallace K, Andersen ME. 2004. Dose-dependent transitions in mechanisms of toxicity. Toxicol Appl Pharmacol 201(3):203-225. PMID:15582645
  • Swenberg JA. 2004. Toxicological considerations in the application and interpretation of DNA adducts in epidemiological studies. IARC Sci Publ 157:237-246. PMID:15055299
  • Zielinska-Park J, Nakamura J, Swenberg JA, Aitken MD. 2004. Aldehydic DNA lesions in calf thymus DNA and HeLa S3 cells produced by bacterial quinone metabolites of fluoranthene and pyrene. Carcinogenesis 25(9):1727-1733. PMID:15117810


  • Albertini R, Clewell H, Himmelstein MW, Morinello EJ, Olin S, Preston J, Scarano L, Smith MT, Swenberg JA, Tice RR, Travis C. 2003. The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene. Regul Toxicol Pharmacol 37(1):105-132. PMID:12662914
  • Barbin A, Ohgaki H, Nakamura J, Kurrer M, Kleihues P, Swenberg JA. 2003. Endogenous deoxyribonucleic acid (DNA) damage in human tissues: A comparison of ethenobases with aldehydic DNA lesions. Cancer Epidemiol Biomarkers Prev 12(11):1241-1247. PMID:14652288
  • Horton JK, Joyce-Gray DF, Pachkowski BF, Swenberg JA, Wilson SH. 2003. Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. DNA Repair (Amst) 2(1):27-48. PMID:12509266
  • Li Y, Boysen G, Dicheva ND, Upton PB, Swenberg JA. 2003. Effects of Free Unmodified Purine Basis, Guanine and Adenine, on Ionization of Three N-7 Guanine DNA Adducts Using LC/ESI/MS/MS. In: Proceedings of the American Society of Mass Spectrometry, 51st Annual Conference.
  • Lin P, Nakamura J, Yamaguchi S, Asakura S, Swenberg JA. 2003. Aldehydic DNA lesions induced by catechol estrogens in calf thymus DNA. Carcinogenesis 24(6):1133-1141. PMID:12807746
  • Nakamura J, Asakura S, Hester SD, de Murcia G, Caldecott KW, Swenberg JA. 2003. Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time. Nucleic Acids Res 31(17):e104. PMID:12930978
  • Nakamura J, Purvis ER, Swenberg JA. 2003. Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells. Nucleic Acids Res 31(6):1790-1795. PMID:12626721
  • Nakamura J, Swenberg JA. 2003. Aldehyde Reactive Probe-Slot Blot Assay to quantitate DNA lesions caused by oxidative stress. In: Methods in Biological Oxidative Stress. Humana Press, pp.109-115.
  • Pachkowski BF, Nakamura J, Li Y, Sangaiah R, Gold A, Swenberg JA. 2003. An LC/MS Approach to the Differentiation of Aldehydic Deoxyribose Lesions. In: Proceedings of the American Association for Cancer Research Annual Meeting, 2003.
  • Williams DE, Bailey GS, Reddy A, Hendricks JD, Oganesian A, Orner GA, Pereira CB, Swenberg JA. 2003. The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters. Toxicol Pathol 31(Suppl.1):58-61. PMID:12597433


  • Koc H, Swenberg JA. 2002. Applications of mass spectrometry for quantitation of DNA adducts. J Chromatogr B Analyt Technol Biomed Life Sci 778(1-2):323-343. PMID:12376138
  • Lin P, La DK, Upton PB, Swenberg JA. 2002. Analysis of DNA adducts in rats exposed to pentachlorophenol. Carcinogenesis 23(2):365-369. PMID:11872646
  • Morinello EJ, Ham AL, Ranasinghe A, Nakamura J, Upton PB, Swenberg JA. 2002. Molecular dosimetry and repair of N2,3-ethenoguanine in rats exposed to vinyl chloride. Cancer Res 62:5189-5195. PMID:12234983
  • Morinello EJ, Koc H, Ranasinghe A, Swenberg JA. 2002. Differential induction of N2,3-ethenoguanine in rat brain and liver after exposure to vinyl chloride. Cancer Res 62:5183-5188.
  • Sobol RW, Watson DE, Nakamura J, Yakes FM, Hou E, Horton JK, Wu J, Van Houten B, Swenberg JA, Tindall KR, Samson LD, Wilson SH. 2002. Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proc Natl Acad Sci U S A 99(14):6860-6865. PMID:11983862
  • Swenberg JA, Georgieva NI, Ham AL, Koc H, Morinello EJ, Ranasinghe A, Upton PB, Walker V. 2002. Linking pharmacokinetics and biomarker data to mechanism of action in risk assessment. Human and Ecological Risk Assessment: An International Journal 8(6):1315-1338.
  • Swenberg JA, Ham AL, Koc H, La DK, Morinello EJ, Pachkowski BF, Ranasinghe A, Upton PB. 2002. Methods for measuring DNA adducts and abasic sites II: methods for measurement of DNA adducts. Curr Protoc Toxicol Chapter3:Unit3.9. doi:10.1002/0471140856.tx0309s12 PMID:23045080
  • Swenberg JA, Ham AL, McDorman KS, Morinello EJ, Nakamura J, Schoonhoven R. 2002. Methods for measuring DNA adducts and abasic sites I: isolation, purification, and analysis of DNA adducts in intact DNA. Curr Protoc Toxicol Chapter3:Unit3.8. doi:10.1002/0471140856.tx0308s12 PMID:23045079
  • Toraason M, Andersen ME, Bogdanffy MS, Dankovic D, Faustman EM, Foster P, Frederick C, Haber L, Kimmel CA, Lewis S, McClellan R, Melnick R, Mirer F, Morgan K, Schaeffer V, Silbergeld EK, Slikker W, Swenberg JA, Vainio H. 2002. Improving risk assessment: toxicological research needs. Human and Ecological Risk Assessment: An International Journal 8(6):1405-1419. doi:10.1080/20028091057439


  • Ham AL, Zhan C, Koc H, Hass RJ, Swenberg JA. 2001. Analysis of 1,N6-ethenodeoxyguanosine by immunoaffinity/LC/MS/MS. In: Proceedings of the 49th ASMS (American Society for Mass Spectrometry) Conference on Mass Spectrometry and Allied Topics. June 4-7. Chicago, IL.
  • Lin P, Nakamura J, Yamaguchi S, La DK, Swenberg JA. 2001. Oxidative damage and direct adducts in calf thymus DNA induced by the pentachlorophenol metabolites, tetrachlorohydroquinone and tetrachloro-1,4-benzoquinone. Carcinogenesis 22(4):627-634. PMID:11285199
  • Lin P, Nakamura J, Yamaguchi S, La DK, Upton PB, Swenberg JA. 2001. Induction of direct adducts, apurinic/apyrimidinic sites and oxidized bases in nuclear DNA of human HeLa S3 tumor cells by tetrachlorohydroquinone. Carcinogenesis 22(4):635-639. PMID:11285200
  • Morinello EJ, Ham AL, Ranasinghe A, Sangaiah R, Swenberg JA. 2001. Simultaneous quantitation of N(2),3-ethenoguanine and 1,N(2)-ethenoguanine with an immunoaffinity/gas chromatography/high-resolution mass spectrometry assay. Chem Res Toxicol 14(3):327-334. PMID:11258983


  • Boivin-Angele S, Lefrancois L, Froment O, Spiethoff A, Bogdanffy MS, Wegener K, Wesch H, Barbin A, Bancel B, Trepo C, Bartsch H, Swenberg JA, Marion M. 2000. Ras gene mutations in vinyl chloride-induced liver tumours are carcinogen-specific but vary with cell type and species. Int J Cancer 85(2):223-227. PMID:10629081
  • Ham AL, Ranasinghe A, Koc H, Swenberg JA. 2000. 4-Hydroxy-2-nonenal and ethyl linoleate from N2,3-ethenoguanine under peroxidizing conditions. Chem Res Toxicol 13:1243-1250.
  • Hayes RB, Zhang L, Yin S, Swenberg JA, Xi L, Wiencke JK, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Zhang D, Wiemels JL, Dosemeci M, Li G, Smith MT. 2000. Genotoxic markers among butadiene-polymer workers in China. Carcinogenesis 21(1):55-62. PMID:10607734
  • Holt S, Roy G, Mitra SR, Upton PB, Bogdanffy MS, Swenberg JA. 2000. Deficiency of N-methylpurine-DNA-glycosylase expression in nonparenchymal cells, the target cell for vinyl chloride and vinyl fluoride. DNA Repair (Amst) 460(2):105-115. PMID:10882851
  • Lin P, Sangaiah R, Ranasinghe A, Upton PB, La DK, Gold A, Swenberg JA. 2000. Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2,2',5,5'-tetrachlorobiphenyl. Chem Res Toxicol 13(8):710-718. PMID:10956058
  • Nakamura J, La DK, Swenberg JA. 2000. 5'-Nicked apurinic/apyrimidinic sites are resistant to b-elimination by b-polymerase and are persistent in human cultured cells after oxidative stress. J Biol Chem 275(8):5323-5328.
  • Rusyn I, Denissenko MF, Wong VA, Butterworth BE, Cunningham ML, Upton PB, Thurman RG, Swenberg JA. 2000. Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency. Carcinogenesis 21(12):2141-2145. PMID:11133801
  • Swenberg JA, Christova-Gueoguieva NI, Upton PB, Ranasinghe A, Scheller NA, Wu K, Yen T, Hayes RB. 2000. 1,3-butadiene: cancer, mutations, and adducts. Part V: Hemoglobin adducts as biomarkers of 1,3-butadiene exposure and metabolism. HEI Research Report No. 92: 1,3-Butadiene and its metabolites: Interspecies comparison of carcinogenicity, mutagenicity and biomarkers. Part V. Hemoglobin adducts as biomarkers of butadiene exposure and metabolism 92:pp.191-219. PMID:10925842
  • Swenberg JA, Ham AL, Koc H, Morinello EJ, Ranasinghe A, Tretyakova N, Upton PB, Wu K. 2000. DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene. Mutat Res 464(1):77-86. doi:10.1016/S1383-5718(99)00168-0 PMID:10633179
  • Walker V, Wu K, Upton PB, Ranasinghe A, Scheller NA, Cho M, Vergnes JS, Skopek TR, Swenberg JA. 2000. Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide. Carcinogenesis 21(9):1661-1669. PMID:10964097


  • Ham AL, Ranasinghe A, Morinello EJ, Nakamura J, Upton PB, Johnson F, Swenberg JA. 1999. Immunoaffinity/gas chromatography/high resolution mass spectrometry method for the detection of N2,3-ethenoguanine. Chem Res Toxicol 12:1240-1246. PMID:10604874
  • Holt S, Bogdanffy MS, Swenberg JA. 1999. The molecular dosimetry and repair of vinyl fluoride-induced DNA adducts. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.335.
  • Ito N, La DK, Holt S, Craft TR, Sills RC, Swenberg JA. 1999. Analysis of ras mutations in forestomach tumors from B6C3F1 mice exposed to 1,2,3-trichloropropane. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.137.
  • La DK, Lin P, Swenberg JA. 1999. Analysis of DNA Adducts in rats chronically exposed to pentachlorophenol. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.330.
  • La DK, Swenberg JA. 1999. The induction of endogenous DNA adducts in tissues of Fischer-344 rats following gavage administration of 1,2,3-trichloropropane. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.131.
  • Lin P, Sangaiah R, Swenberg JA. 1999. Adducts of 2,3,2',5'-tetrachlorobiphenyl-derived ortho-quinone with rat liver proteins after metabolic activation in vitro. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.330.
  • Lin P, Waidyanatha S, Pollack GM, Swenberg JA, Rappaport SM. 1999. Dose-specific production of chlorinated quinone and semiquinone adducts in rodent livers following administration of pentachlorophenol. Toxicol Sci 47(1):126-133. PMID:10048161
  • Mitro KL, Scheller NA, Ranasinghe A, Swenberg JA. 1999. Quantitation of endogenous N2,3-ethenoguanine in human and rat liver DNA using high resolution mass spectrometry. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.847.
  • Nakamura J, Swenberg JA. 1999. Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues. Cancer Res 59(11):2522-2526. PMID:10363965
  • Nakamura J, Walker V, Upton PB, Swenberg JA. 1999. Characterization of a newly developed AP site assay that uses an aldehyde reactive probe-Slot-Blot method. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.480.
  • Swenberg JA, Bogdanffy MS, Ham AL, Holt S, Kim AH, Morinello EJ, Ranasinghe A, Scheller NA, Upton PB. 1999. Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride- induced carcinogenesis. IARC Sci Publ 150:29-43. PMID:10626206
  • Swenberg JA, Lehman-McKeeman LD. 1999. alpha 2-Urinary globulin-associated nephropathy as a mechanism of renal tubule cell carcinogenesis in male rats. IARC Sci Publ (147):95-118. PMID:10457913
  • Wu K, Ranasinghe A, Upton PB, Scheller NA, Swenberg JA. 1999. Endogenous formation of the major DNA adduct of ethylene oxide in humans, rats, and mice. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.102.
  • Wu K, Ranasinghe A, Upton PB, Walker V, Swenberg JA. 1999. Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl)guanine formation in tissues of rodents. Carcinogenesis 20:1787-1792. PMID:10469625
  • Wu K, Scheller NA, Cho M, Ranasinghe A, Upton PB, Walker V, Swenberg JA. 1999. Molecular dosimetry of hydroxyethyl adducts in DNA and hemoglobin following exposure of rats and mice to ethylene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.839.
  • Wu K, Scheller NA, Ranasinghe A, Yen T, Sangaiah R, Giese RW, Swenberg JA. 1999. A gas chromatography/electron capture/negative chemical ionization-high resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring. Chem Res Toxicol 12(8):722-729. PMID:10458706


  • Ham AL, Swenberg JA. 1998. Immunoaffinity (IA) gas chromatography/mass spectometry (GC/MS) method for N2,3-ethenoguanine demonstrates importance of hydrolysis method for adduct quantitation. Fundam Appl Toxicol 42:180.
  • Holt S, Sangaiah R, Swenberg JA. 1998. Detection of 1,N6-ethenoadenine in rat urine after chloroethylene oxide exposure. Carcinogenesis 19(10):1763-1769. PMID:9806156
  • Holt S, Scheller NA, Mitra SR, Bogdanffy MS, Swenberg JA. 1998. Formation and repair of vinyl fluoride-induced DNA adducts. Fundam Appl Toxicol 42:180.
  • Law JM, Bull M, Nakamura J, Swenberg JA. 1998. Molecular dosimetry of DNA adducts in the medaka small fish model. Carcinogenesis 19(3):515-518. PMID:9525288
  • Nakamura J, Walker V, Upton PB, Chiang S, Kow YW, Swenberg JA. 1998. Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions. Cancer Res 58(2):222-225. PMID:9443396
  • Ploch SA, Nakamura J, Swenberg JA, Di Giulio RT. 1998. Assessment of AP site formation in isolated hepatocytes from brown bullhead upon treatment with benzo(a)pyrene. Fundam Appl Toxicol 42:82.
  • Ranasinghe A, Ham AL, Morinello EJ, Swenberg JA. 1998. Quantitation of 1, N2-ethenoguanine and N2, 3-ethenoguanine by IAC/GC/ECNCI/HRMS. In: Proceedings of the 46th ASMS (American Society for Mass Spectrometry) Conference on Mass Spectrometry and Allied Topics.
  • Ranasinghe A, Scheller NA, Wu K, Upton PB, Swenberg JA. 1998. Application of gas chromatography/electron capture negative chemical ionization/high resolution mass spectrometry for analysis of DNA and protein adducts. Chem Res Toxicol 11:520-526. PMID:9585483
  • Yen T, Holt S, Sangaiah R, Gold A, Swenberg JA. 1998. Quantitation of 1,N6 ethenoadenine in rat urine by immunoaffinity extraction combined with liquid chromatography/electrospray ionization mass spectrometry. Chem Res Toxicol 11(7):810-815. PMID:9671544


  • La DK, Swenberg JA. 1997. Carcinogenic alkylating agents. In: Comprehensive Toxicology, Vol. 12, Chemical Carcinogens and Anticarcinogens. Elsevier Science, Oxford, United Kingdom. pp.111-140.
  • Scheller NA, Ranasinghe A, Bogdanffy MS, Swenberg JA. 1997. Detection of N2,3-ethenoguanine by GC/HR-MS in brains and kidneys in vinyl fluoride exposed rodents. Fundam Appl Toxicol 36:94.
  • Swenberg JA. 1997. Generating data for scientifically-based risk assessment. Fundam Appl Toxicol 36:286.
  • Swenberg JA. 1997. In vivo studies on the formation and repair of DNA adducts. In: Proceedings of Environmental Mutagen Society Meeting, 1997. Minneapolis, MN.
  • Wu K, Ranasinghe A, Scheller NA, Upton PB, Swenberg JA. 1997. Mechanism-based risk assessment: utility of DNA adducts in model selection. Fundam Appl Toxicol 36:97.
  • Yen T, Wu K, Holt S, Sangaiah R, Swenberg JA. 1997. Determination of DNA adducts from ethylene oxide and vinyl chloride exposure. In: Proceedings of the 45th AMS (American Society of Microbiology) Conference on Mass Spectrometry and Allied Topics. pp.295.


  • Chiang S, Swenberg JA, Weisman WA, Skopek TR. 1996. Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line. Carcinogenesis 18(1):31-36. PMID:9054586
  • Christova-Gueoguieva NI, Yen T, Scheller NA, Holt S, Swenberg JA. 1996. Quantitation of N2,3-ethenoguanine (epsilonG) in rat liver by liquid chromatography-electrospray mass spectrometry. Environ Health Perspect 30(1,part2):235.
  • Holt S, Swenberg JA. 1996. Age-dependent modulation of tissue-specific repair activity for methylpurine glycosylase. Environ Health Perspect 30(1,part2):236.
  • La DK, Schoonhoven R, Ito N, Swenberg JA. 1996. The effects of exposure route on DNA adduct formation and cellular proliferation by 1,2,3-trichloropropane. Toxicol Appl Pharmacol 140(1):108-114. PMID:8806876
  • La DK, Swenberg JA, Ham AL, Koc H, Morinello EJ, Ranasinghe A, Tretyakova N, Upton PB, Wu K. 1996. DNA adducts: Biological markers of exposure and potential applications to risk assessment. Mutat Res 365:129-146. PMID:8898994
  • Ranasinghe A, Scheller NA, Wu K, Swenberg JA. 1996. GC/ECNCI/MS/MS Analysis of electrophore-labeled DNA adducts. In: Proceedings of the 44th ASMS (American Society for Mass Spectrometry) on Mass Spectrometry and Allied Topics. Portland, OR.
  • Scheller NA, Ranasinghe A, Christova-Gueoguieva NI, Yen T, Ham AL, Swenberg JA. 1996. Detection of Endogenous N2,3-ethenoguanine by GC/ECNCI/MS. In: Proceedings of the 44th ASMS (American Society for Mass Spectrometry) on Mass Spectrometry and Allied Topics. Portland, OR. pp.781.
  • Swenberg JA, La DK, Scheller NA, Wu K. 1996. Dose-response relationships for carcinogens. Toxicol Lett 82-3:751-756. PMID:8597138
  • Swenberg JA, Scheller NA, Ranasinghe A, Upton PB, Christova-Gueoguieva NI, Bogdanffy MS. 1996. Molecular dosimetry of N2,3-ethenoguanine in DNA of vinyl fluoride-exposed rats: relationship to hemangiosarcoma. Environ Health Perspect 30(1,part2):235.
  • Yen T, Christova-Gueoguieva NI, Scheller NA, Holt S, Swenberg JA, Charles MJ. 1996. HPLC/ESI/MS May be the Technique of Choice for the Analysis of Certain DNA Adducts. In: Proceedings of the 44th ASMS (American Society for Mass Spectrometry) on Mass Spectrometry and Allied Topics. Portland, OR. pp.780.
  • Yen T, Christova-Gueoguieva NI, Scheller NA, Holt S, Swenberg JA, Charles MJ. 1996. Quantitative analysis of the DNA adduct N2,3-ethenoguanine using liquid chromatography/electrospray ionization mass spectrometry. J Mass Spectrom 31(11):1271-1276. PMID:8946734


  • Chiang S, Craft TR, Skopek TR, Swenberg JA. 1995. Mutation spectra of vinyl chloride (VC) and chloroethylene oxide (CEO) at the hprt gene in metabolically-competent human lymphoblastoid lines. International Toxicologist 7(1):46P9.
  • Chiang S, Skopek TR, Swenberg JA. 1995. Mutagenicity of vinyl chloride and its metabolites, and vinyl fluoride in a metabolically competent human lymphoblastoid line. Environ Health Perspect 15(1):79.
  • Holt S, Swenberg JA. 1995. Detection of 1,N6-ethenoadenine excreted in rat urine after chloroethylene oxide exposure. Environ Health Perspect 15(1):77.
  • Scheller NA, Ranasinghe A, Kim AH, Holt S, Bogdanffy MS, Swenberg JA. 1995. High resolution GC/MS detection of N2,3-ethenoguanine in livers of control and vinyl fluoride-exposed B6C3F1 mice. International Toxicologist 7(1):6P21.
  • Scheller NA, Sangaiah R, Ranasinghe A, Amarnath V, Gold A, Swenberg JA. 1995. Synthesis of [4,5,6,8-13C4]guanine, a reagent for the production of internal standards of guanyl DNA adducts. Chem Res Toxicol 8(3):333-337. PMID:7578918
  • Swenberg JA. 1995. Bioassay design and MTD setting: old methods and new approaches. Regul Toxicol Pharmacol 21:44-51. PMID:7784635
  • Swenberg JA. 1995. Carcinogenesis. In: Patty's Industrial Hygiene and Toxicology, 3rd edition, Volume 4, Part B. Wiley and Sons, New York, NY. pp.255-273.
  • Yen T, Christova-Gueoguieva NI, Scheller NA, Swenberg JA, Charles MJ. 1995. Quantitative analysis of DNA adducts by using HPLC/ESI-MS. In: Proceedings of the 43rd ASMS (American Society for Mass Spectrometry) Conference on Mass Spectrometry and Allied Topics. pp.497.
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