Superfund Research Program
Epidemiology, Biomarkers and Exposure Assessment of Metals
Project Leader: Margaret R. Karagas
Grant Number: P42ES007373
Funding Period: 1995-2021
Project-Specific Links
Title: The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood
Accession Number: GSE26543
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE26543
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Methylation profiling by array
Organism(s): Homo sapiens
Summary: Genome wide DNA methylation profiling of non-pathologic peripheral blood from subjects with no history of cancer. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in peripheral blood. Samples included 205 normal control peripheral blood samples.
Publication(s) associated with this dataset:- Langevin SM, Houseman EA, Christensen BC, Wiencke JK, Nelson HH, Karagas MR, Marsit CJ, Kelsey KT. 2011. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics 6:908-919. doi:10.4161/epi.6.7.16431 PMID:21617368 PMCID:PMC3154431 (Completed with ARRA Funds)