Title: Transcription profiling by array of mouse wild type and Fibroblast specific protein 1 expressing liver

Accession Number: E-MTAB-287

Link to Dataset: http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-287/

Repository: ArrayExpress

Data Type(s): Gene Expression

Experiment Type(s): Transcription profiling by array

Organism(s): Mus musculus

Summary: The aim of this study was to investigate FSP1 in human and experimental liver disease, and to characterize FSP1-positive cells. Results: FSP1-positive cells are increased in human and experimental liver diseases including liver cancer but do not synthesize type I collagen or express other classical markers of myofibroblasts including aSMA and desmin. Surprisingly, FSP1 positive cells express F4/80 and other markers characteristic of the myeloid-monocytic lineage as evaluated by double-immunofluorescence staining, cell fate tracking, flow cytometry andtranscriptional profiling. Conclusion: These findings suggest that FSP1 is a marker of a subset of macrophages in liver injury, fibrosis and cancer.

Publication(s) associated with this dataset:

• Osterreicher C, Penz-Osterreicher M, Grivennikov S, Guma M, Koltsova E, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. 2011. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 108(1):308-313. doi:10.1073/pnas.1017547108 PMID:21173249 PMCID:PMC3017162