Superfund Research Program
Dr. Michael Karin
University of California-San Diego
Department of Pharmacology
Leichtag Biomedical Research Building, Room 214
9500 Gilman Dr., MC 0723
La Jolla, California 92093-0723
Phone: 858-534-1361
Fax: 858-534-8158
Email: karinoffice@health.ucsd.edu
Projects
- University of California-San Diego: Administrative Core (2000-2023)
- University of California-San Diego: Control of Toxin and Obesity Induced Liver Fibrosis by B Cells (2017-2023)
- University of California-San Diego: Effects of Superfund Toxicants on Liver Cancer Progenitor Cells (2000-2017)
Research Briefs
- 284 - Researchers Pinpoint Molecule Fueling Liver Cancer Development
- 278 - Chronic Inflammation Suppresses Immune Cells that Fight Liver Cancer
- 249 - Newly Discovered Cells Regenerate Liver Tissue Without Forming Tumors
- 118 - Evidence of a Molecular Link Between Inflammation and Cancer
- 94 - Anthrax invades and evades the immune system to cause widespread infection
Patents
- A Serum Biomarker for NASH
- Isolation of Hepatocytes with High Regenerative Capacity For Repair of Liver Injuries
- Methods for Identifying I.kappa.B Kinase (IKK) Inhibitors
- Methods for inhibiting nonalcoholic steatohepatitis, nonalcoholic fatty-liver disease, and/or de novo lipogenesis
- Methods for treating NLRP3 inflammasome-associated disease, and methods of identifying agents useful thereof
- Mouse Model for Human NASH and Steatolic Hepatocellular Carcinoma
Publications
2024
- Weber AA, Yang X, Mennillo E, Wong S, Le S, Tukey RH, Ashley Teo J, Chang M, Benner CW, Ding J, Jain M, Chen S, Karin M. 2024. Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4. J Biol Chem 300(6):doi:10.1016/j.jbc.2024.107340 PMID:38705390
2023
- Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest AR, Tirnitz-Parker JE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. 2023. Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC. Sci Adv 9(37):eadh0831. doi:10.1126/sciadv.adh0831 PMID:37703359 PMCID:PMC10499313
- He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M. 2023. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. J Hepatol 79(2):362-377. doi:10.1016/j.jhep.2023.03.016 PMID:36996941
- Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts P, Tukey RH, Chen S. 2023. Effects of early life oral arsenic exposure on intestinal tract development and lipid homeostasis in neonatal mice: Implications for NAFLD development. Environ Health Perspect 131(9):doi:10.1289/ehp12381 PMID:37668303 PMCID:10478510
2022
- Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. 2022. Metabolic injury of hepatocytes promotes progression of NAFLD and AALD. Semin Liver Dis 42(3):233-249. doi:10.1055/s-0042-1755316 PMID:36001995
- Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KC, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. 2022. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab 34(8):1201-1213. doi:10.1016/j.cmet.2022.07.006 PMID:35921818 PMCID:PMC9365100
- Kim J, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. 2022. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab 34(10):1548-1560. doi:10.1016/j.cmet.2022.08.005 PMID:36041455 PMCID:PMC9547947
- Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. 2022. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun 13(1):4346. doi:10.1038/s41467-022-31947-4 PMID:35896521 PMCID:PMC9329322
2021
- Febbraio MA, Karin M. 2021. Sweet death: Fructose as a metabolic toxin that targets the gut-liver axis. Cell Metab 33(12):doi:10.1016/j.cmet.2021.09.004 PMID:34619076 PMCID:PMC8665123
- Kim J, He F, Karin M. 2021. From liver fat to cancer: Perils of the Western diet. Cancers (Basel) 13(5):doi:10.3390/cancers13051095 PMID:33806428 PMCID:PMC7961422
- Okuda K, Umemura A, Umemura S, Kataoka S, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Kanbara Y, Arbiser J, Shima T, Okanoue T, Karin M, Itoh Y. 2021. Honokiol prevents nonalcoholic steatohepatitis induced liver cancer via EGFR degradation through the glucocorticoid receptor MIG6 axis. Cancers (Basel) 13(7):doi:10.3390/cancers13071515 PMID:33806040 PMCID:PMC8037653
- Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre J, Arditi M, Karin M, Sanchez-Lopez E. 2021. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity 54:1463-1477. doi:10.1016/j.immuni.2021.05.004 PMID:34115964 PMCID:PMC8189765
2020
- He F, Antonucci L, Karin M. 2020. NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis 41:doi:10.1093/carcin/bgaa039 PMID:32347301 PMCID:PMC7298623 (accepted for publication)
- He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Molina AD, Diaz-Meco MT, Moscat J, Sun B, Karin M. 2020. NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. J Hepatol 72:1182-1195. doi:10.1016/j.jhep.2020.01.023 PMID:32105670
- Ma H, Yamamoto G, Xu J, Liu X, Karin D, Kim J, Alexandrov LB, Koyama Y, Nishio T, Benner CW, Heinz S, Rosenthal S, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop I, Quehenberger O, Dennis EA, Saltiel AR, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. 2020. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol 72:946-959. doi:10.1016/j.jhep.2019.12.016 PMID:31899206 PMCID:PMC7167339
- Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ, Karin M. 2020. NF-kB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. Cell Death Differ 27:doi:10.1038/s41418-020-0496-1 PMID:31992855 PMCID:PMC7308363
- Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac AF, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. 2020. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab 2:1034-1045. doi:10.1038/s42255-020-0261-2 PMID:32839596 PMCID:PMC8018782
- Xu J, Ma H, Liu X, Rosenthal SB, Baglieri J, Mccubbin R, Sun M, Koyama Y, Geoffroy C, Saijo K, Shang L, Nishio T, Maricic I, Kriefeldt M, Kusumanchi P, Roberts a, Zheng B, Kumar V, Zengler K, Pizzo D, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob G, Kisseleva T. 2020. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight doi:10.1172/jci.insight.131277 PMID:32051339 PMCID:PMC7098802
- Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. 2020. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 117:31259-31266. doi:10.1073/pnas.2017129117 PMID:33229553 PMCID:PMC7733785
- Zhao P, Sun X, Chaggan C, Liao Z, Wong KI, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. 2020. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science 367:doi:10.1126/science.aay0542 PMID:32029622 PMCID:PMC8012106 (accepted for publication)
2019
- Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M. 2019. Preclinical models for studying NASH-driven HCC: How useful are they?. Cell Metab 29:18-26. doi:10.1016/j.cmet.2018.10.012 PMID:30449681 PMCID:PMC6326872
- Liang S, Ma H, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. 2019. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology 156(4):1156-1172. doi:10.1053/j.gastro.2018.11.019 PMID:30445007 PMCID:PMC6409207
- Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. 2019. Choline Uptake and metabolism modulate macrophage IL-1 beta and IL-18 production. Cell Metab 29:1350. doi:10.1016/j.cmet.2019.03.011 PMID:30982734 PMCID:PMC6675591
2018
- Dhar D, Antonucci L, Nakagawa H, Kim J, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. 2018. Liver cancer initiation requires p53 inhibition by CD44-enhanced growth factor signaling. Cancer Cell 33:1061. doi:10.1016/j.ccell.2018.05.003 PMID:29894692 PMCID:PMC6005359
- Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. 2018. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A 115:E9879-E9888. doi:10.1073/pnas.1811029115 PMID:30287485 PMCID:PMC6196518
- Karin M. 2018. New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance. Precis Clin Med 1(1):21-28. doi:10.1093/pcmedi/pby005 PMID:30687560 PMCID:PMC6333043
- Kim J, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. 2018. ER stress drives lipogenesis and steatohepatitis via caspase-2 activation of S1P. Cell 175(1):133-145. doi:10.1016/j.cell.2018.08.020 PMID:30220454 PMCID:PMC6159928
- Song N, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Xu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. 2018. IKK alpha inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A 115:E812-E821. doi:10.1073/pnas.1717520115 PMID:29311298 PMCID:PMC5789942
- Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. 2018. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15:397-411. doi:10.1038/s41575-018-0011-z PMID:29748586 PMCID:PMC6319369
- Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin X, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. 2018. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature 560:198-203. doi:10.1038/s41586-018-0372-z PMID:30046112 PMCID:PMC6329306
2017
- Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 114(8):E1432-E1440. doi:10.1073/pnas.1700232114 PMID:28167773 PMCID:PMC5338369
- Shalapour S, Lin X, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner CW, Anstee QM, Karin M. 2017. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551(7680):340-345. doi:10.1038/nature24302 PMID:29144460 PMCID:PMC5884449
2016
- Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J. 2016. p62/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis, and liver cancer. Cancer Cell 30(4):595-609. doi:10.1016/j.ccell.2016.09.004 PMID:27728806 PMCID:PMC5081228
- Hee Lee J, Cho U, Karin M. 2016. Sestrin regulation of TORC1: Is Sestrin a leucine sensor?. Sci Signal 9(431):re5. doi:10.1126/scisignal.aaf2885 PMID:27273098 PMCID:PMC4902175
- Karin M, Clevers H. 2016. Reparative inflammation takes charge of tissue regeneration. Nature 529(7586):307-315. doi:10.1038/nature17039 PMID:26791721 PMCID:PMC5228603
- Karin M, Dhar D. 2016. Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. Carcinogenesis 37(6):541-546. doi:10.1093/carcin/bgw060 PMID:27207669 PMCID:PMC4876993
- Moscat J, Karin M, Diaz-Meco MT. 2016. p62 in cancer: signaling adaptor beyond autophagy. Cell 167(3):606-609. doi:10.1016/j.cell.2016.09.030 PMID:27768885 PMCID:PMC5114003
- Taniguchi K, Yamachika S, He F, Karin M. 2016. p62/SQSTM1-Dr Jekyll and Mr Hyde that prevents oxidative stress but promotes liver cancer. FEBS Lett 590(15):2375-2397. doi:10.1002/1873-3468.12301 PMID:27404485 PMCID:PMC4983218
- Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. 2016. p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell 29(6):935-948. doi:10.1016/j.ccell.2016.04.006 PMID:27211490 PMCID:PMC4907799
- Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins GA, Ali S, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. 2016. NF-κB restricts inflammasome activation via elimination of damaged mitochondria. Cell 164(5):896-910. doi:10.1016/j.cell.2015.12.057 PMID:26919428 PMCID:PMC4769378
2015
- Antonucci L, Fagman JB, Kim J, Todoric J, Gukovsky I, Mackey MR, Ellisman MH, Karin M. 2015. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A 112(45):E6166-E6174. doi:10.1073/pnas.1519384112 PMID:26512112 PMCID:PMC4653219
- Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol 16(12):1235-1244. doi:10.1038/ni.3290 PMID:26502405 PMCID:PMC4653079
- Font-Burgada J, Shalapour S, Ramasamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. 2015. Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer. Cell 162(4):766-779. doi:10.1016/j.cell.2015.07.026 PMID:26276631 PMCID:PMC4545590
2014
- Dhar D, Seki E, Karin M. 2014. NCOA5, IL-6, type 2 diabetes, and HCC: the deadly quartet. Cell Metab 19(1):6-7. doi:10.1016/j.cmet.2013.12.010 PMID:24411937 PMCID:PMC3947913
- Inokuchi-Shimizu S, Park E, Roh Y, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky J, Karin M, Brenner DA, Seki E. 2014. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest 124(8):3566-3578. doi:10.1172/JCI74068 PMID:24983318 PMCID:PMC4109552
- Moles A, Murphy L, Wilson C, Chakraborty JB, Fox C, Park E, Mann J, Oakley F, Howarth R, Brain JD, Masson S, Karin M, Seki E, Mann DA. 2014. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol 60(4):782-791. doi:10.1016/j.jhep.2013.12.005 PMID:24333183 PMCID:PMC3960359
- Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. 2014. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell 26(3):331-343. doi:10.1016/j.ccr.2014.07.001 PMID:25132496 PMCID:PMC4165611
- Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan K, Karin M, Budanov AV. 2014. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep 9(4):1281-1291. doi:10.1016/j.celrep.2014.10.019 PMID:25457612 PMCID:PMC4303546
- Umemura A, Park E, Taniguchi K, Lee J, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. 2014. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab 20(1):133-144. doi:10.1016/j.cmet.2014.05.001 PMID:24910242 PMCID:PMC4079758
- Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A 111(48):17200-17205. doi:10.1073/pnas.1419119111 PMID:25404284 PMCID:PMC4260592
2013
- Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. 2013. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A 110(47):19143-19148. doi:10.1073/pnas.1319123110 PMID:24191041 PMCID:PMC3839688
- Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. 2013. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A 110(6):2377-2382. doi:10.1073/pnas.1221729110 PMID:23341606 PMCID:PMC3568328
- He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. 2013. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell 155(2):384-396. doi:10.1016/j.cell.2013.09.031 PMID:24120137 PMCID:PMC4015514
- Lee J, Budanov AV, Karin M. 2013. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab 18(6):792-801. doi:10.1016/j.cmet.2013.08.018 PMID:24055102 PMCID:PMC3858445
- Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. 2013. p38αlpha inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res 73(1):215-224. doi:10.1158/0008-5472.CAN-12-1602 PMID:23271722 PMCID:PMC3605785
2012
- Fujiwara R, Chen S, Karin M, Tukey RH. 2012. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-kappa B leads to hyperbilirubinemia. Gastroenterology 142:109-U259. doi:10.1053/j.gastro.2011.09.045 PMID:21983082 PMCID:PMC3428231
- Lee J, Budanov AV, Talukdar S, Park E, Park H, Park H, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. 2012. Maintenance of metabolic homeostasis by Sestrin 2 and Sestrin 3. Cell Metab 16(3):311-321. doi:10.1016/j.cmet.2012.08.004 PMID:22958918 PMCID:PMC3687365
- Seki E, Brenner DA, Karin M. 2012. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology 143(2):307-320. doi:10.1053/j.gastro.2012.06.004 PMID:22705006 PMCID:PMC3523093
- Sun B, Karin M. 2012. Obesity, inflammation, and liver cancer. J Hepatol 56(3):704-713. doi:10.1016/j.jhep.2011.09.020 PMID:22120206 PMCID:PMC3889660
- Yu G, He G, Li C, Tang M, Grivennikov S, Tsai W, Wu M, Hsu C, Tsai Y, Wang L, Karin M. 2012. Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell 48(2):313-321. doi:10.1016/j.molcel.2012.07.032 PMID:22959272 PMCID:PMC3483424
2011
- Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. 2011. An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 147(6):1233-1247. doi:10.1016/j.cell.2011.10.043 PMID:22153071 PMCID:PMC3251960
- Holzer RG, Park E, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. 2011. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147(1):173-184. doi:10.1016/j.cell.2011.08.034 PMID:21962514 PMCID:PMC3295636
- Osterreicher C, Penz-Osterreicher M, Grivennikov S, Guma M, Koltsova E, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. 2011. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 108(1):308-313. doi:10.1073/pnas.1017547108 PMID:21173249 PMCID:PMC3017162
2010
- Bodmer R, Bier E, Karin M, Lee J. 2010. Sestrins at the crossroad between stress and aging. Aging-US 2(6):369-374. doi:10.18632/aging.100157 PMID:20606249 PMCID:PMC2919257
- Budanov AV, Lee J, Karin M. 2010. Stressin' Sestrins take an aging fight. EMBO Mol Med 2(10):388-400. doi:10.1002/emmm.201000097 PMID:20878915 PMCID:PMC3166214
- Lee J, Budanov AV, Park E, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. 2010. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327(5970):1223-1228. doi:10.1126/science.1182228 PMID:20203043 PMCID:PMC2866632
- Park E, Lee J, Yu G, He G, Ali S, Holzer RG, Osterreicher CH, Takahashi H, Karin M. 2010. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140(2):197-208. doi:10.1016/j.cell.2009.12.052 PMID:20141834 PMCID:PMC2836922
2009
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