Superfund Research Program
Effect of Underlying Liver Diseases on Fibrosis Induced by Superfund Toxicants
Project Leader: David A. Brenner
Grant Number: P42ES010337
Funding Period: 2011-2017
Project-Specific Links
- Project Summary
Title: Gene expression profile of WT and TAK1 KO livers.
Accession Number: GSE51962
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE51962
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Expression profiling by array
Organism(s): Mus musculus
Summary: The effect of ablation of Tak1 gene in the liver was characterized.
Publication(s) associated with this dataset:- Inokuchi-Shimizu S, Park E, Roh Y, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky J, Karin M, Brenner DA, Seki E. 2014. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest 124(8):3566-3578. doi:10.1172/JCI74068 PMID:24983318 PMCID:PMC4109552