Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document

Your Environment. Your Health.

Person Details: David A. Brenner

Superfund Research Program

David A. Brenner

University of California-San Diego
9500 Gilman Drive, MC 0602
La Jolla, California 92093-0602
Phone: 858-534-1501
Fax: 858-822-0084
Email: dbrenner@health.ucsd.edu

Projects

Research Briefs

Publications

2024

  • Tan P, Ostertag T, Rosenthal SB, Chilin-Fuentes D, Aidnik H, Linker S, Murphy K, Miner J, Brenner DA. 2024. Role of hepatic stellate and liver sinusoidal endothelial cells in a human primary cell three-dimensional model of nonalcoholic steatohepatitis. Am J Pathol 194(3):353-368. doi:10.1016/j.ajpath.2023.12.005 PMID:38158078 PMCID:10913759

2023

  • Kim HY, Sakane S, Eguileor A, Weber RC, Lee W, Liu X, Lam K, Ishizuka K, Rosenthal SB, Diggle K, Brenner DA, Kisseleva T. 2023. The origin and fate of liver myofibroblasts. Cell Mol Gastroenterol Hepatol 17(1):93-106. doi:10.1016/j.jcmgh.2023.09.008 PMID:37743012 PMCID:PMC10665929
  • Liu X, Lam K, Zhao H, Sakane S, Kim HY, Eguileor A, Diggle K, Wu S, Weber RC, Soroosh P, Hosseini M, Mekeel K, Brenner DA, Kisseleva T. 2023. Isolation of primary human liver cells from normal and nonalcoholic steatohepatitis livers. STAR Protoc 4(3):102391. doi:10.1016/j.xpro.2023.102391 PMID:37405925 PMCID:PMC10345194
  • Zeng S, Rosati E, Saggau C, Messner B, Chu H, Duan Y, Hartmann P, Wang Y, Ma S, Huang WJ, Lee J, Lee SM, Carvalho-Gontijo R, Zhang V, Hoffmann JP, Kolls J, Raz E, Brenner DA, Kisseleva T, LeibundGut-Landmann S, Bacher P, Starkel P, Schnabl B. 2023. Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease. Cell Host Microbe 31(3):389-404. doi:10.1016/j.chom.2023.02.001 PMID:36893735 PMCID:PMC1003970

2022

  • Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. 2022. Metabolic injury of hepatocytes promotes progression of NAFLD and AALD. Semin Liver Dis 42(3):233-249. doi:10.1055/s-0042-1755316 PMID:36001995
  • Gao H, Jin Z, Bandyopadhyay G, Rocha KC, Liu X, Zhao H, Zhang D, Jouihan H, Pourshahian S, Kisseleva T, Brenner DA, Ying W, Olefsky J. 2022. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Cell Metab 34(7):978-990. doi:10.1016/j.cmet.2022.05.008 PMID:35700738 PMCID:PMC9262870
  • Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KC, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. 2022. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab 34(8):1201-1213. doi:10.1016/j.cmet.2022.07.006 PMID:35921818 PMCID:PMC9365100
  • Nishio T, Koyama Y, Fuji H, Ischizuka K, Iwaisako K, Taura K, Hatano E, Brenner DA, Kisseleva T. 2022. The role of mesothelin in activation of portal fibroblasts in cholestatic liver injury. Biology (Basel) 11(11):1589. doi:10.3390/biology11111589 PMID:36358290

2021

  • Rosenthal SB, Liu X, Ganguly S, Dhar D, Pasillas M, Ricciardelli E, Li RZ, Troutman T, Kisseleva T, Glass CK, Brenner DA. 2021. Heterogeneity of HSCs in a mouse model of NASH. Hepatology 74(2):667-685. doi:10.1002/hep.31743 PMID:33550587 PMCID:PMC8346581
  • Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li S, Welch R, Huang F, Qi L, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu E, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. 2021. Intestinal a1-2-fucosylation contributes to obesity and steatohepatitis in mice. Cell Mol Gastroenterol Hepatol 12(1):doi:10.1016/j.jcmgh.2021.02.009 PMID:33631374 PMCID:PMC8166943

2020

  • Dhar D, Baglieri J, Kisseleva T, Brenner DA. 2020. Mechanisms of liver fibrosis and its role in liver cancer. Exp Biol Med (Maywood) 13:doi:10.1177/1535370219898141 PMID:31924111 PMCID:PMC7016420
  • Ma H, Yamamoto G, Xu J, Liu X, Karin D, Kim J, Alexandrov LB, Koyama Y, Nishio T, Benner CW, Heinz S, Rosenthal S, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop I, Quehenberger O, Dennis EA, Saltiel AR, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. 2020. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol 72:946-959. doi:10.1016/j.jhep.2019.12.016 PMID:31899206 PMCID:PMC7167339
  • Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba E, Bettencourt R, Richards L, Raffatellu M, Dorrestein PC, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin C, Knight R, Downes M, Evans RM, Loomba R. 2020. A universal gut-microbiome-derived signature predicts cirrhosis. Cell Metab 32:doi:10.1016/j.cmet.2020.10.015 PMID:33147487 PMCID:PMC7891106 (accepted for publication)
  • Sun X, Seidman J, Zhao P, Troutman T, Spann N, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida J, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. 2020. Neutralization of oxidized phospholipids ameliorates non-alcoholic steatohepatitis. Cell Metab 31(1):189-206. doi:10.1016/j.cmet.2019.10.014 PMID:31761566 PMCID:PMC7028360
  • Xu J, Ma H, Liu X, Rosenthal SB, Baglieri J, Mccubbin R, Sun M, Koyama Y, Geoffroy C, Saijo K, Shang L, Nishio T, Maricic I, Kriefeldt M, Kusumanchi P, Roberts a, Zheng B, Kumar V, Zengler K, Pizzo D, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob G, Kisseleva T. 2020. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight doi:10.1172/jci.insight.131277 PMID:32051339 PMCID:PMC7098802

2019

  • Baglieri J, Brenner DA, Kisseleva T. 2019. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Int J Mol Sci 20(7):1723. doi:10.3390/ijms20071723 PMID:30959975 PMCID:PMC6479943
  • Caussy C, Bhargava M, Villesen I, Gudmann N, Leeming D, Karsdal M, Faulkner C, Bao D, Liu A, Lo M, Bettencourt R, Bassirian S, Richards L, Brenner DA, Chen C, Sirlin C, Loomba R. 2019. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Hepatology 70(1):127-141. doi:10.1002/hep.30610 PMID:30859582 PMCID:PMC6984974
  • Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R, Rizo E, Richards L, Xu Z, Downes M, Evans RM, Brenner DA, Sirlin CB, Knight R, Loomba R. 2019. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat Commun 10:1406. doi:10.1038/s41467-019-09455-9 PMID:30926798 PMCID:PMC6440960
  • Liang S, Ma H, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. 2019. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology 156(4):1156-1172. doi:10.1053/j.gastro.2018.11.019 PMID:30445007 PMCID:PMC6409207
  • Wang L, Mazagova M, Pan C, Yang S, Brandl KL, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. 2019. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A 116:15184-15193. doi:10.1073/pnas.1904360116 PMID:31289229 PMCID:PMC6660779

2018

  • Brenner DA. 2018. Of Mice and Men and Nonalcoholic Steatohepatitis. Hepatology 68(6):2059-2061. doi:10.1002/hep.30186 PMID:30033687 PMCID:PMC6398944
  • Caussy C, Hsu CL, Lo M, Liu A, Bettencourt R, Ajmera VH, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner DA, Sirlin CB, Chen C, Loomba R. 2018. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology 68(3):918-932. doi:10.1002/hep.29892 PMID:29572891 PMCID:PMC6151296
  • Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Starkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. 2018. Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. Hepatology doi:10.1002/hep.29676 PMID:29159825 PMCID:PMC5962369
  • Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. 2018. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15:397-411. doi:10.1038/s41575-018-0011-z PMID:29748586 PMCID:PMC6319369

2017

  • Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen C, Al Ikhwan M, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner DA, Sirlin CB, Loomba R. 2017. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest 127(7):2697–2704. doi:10.1172/JCI93465 PMID:28628033 PMCID:PMC5490764
  • Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH. 2017. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. JCI Insight 2(24):92821. doi:10.1172/jci.insight.92821 PMID:29263300 PMCID:PMC5752303
  • Koyama Y, Brenner DA. 2017. Liver inflammation and fibrosis. J Clin Invest 127(1):55-64. doi:10.1172/JCI88881 PMID:28045404 PMCID:PMC5199698
  • Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner CW, Heinz S, Bera T, Brenner DA, Kisseleva T. 2017. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest 127(4):1254-1270. doi:10.1172/JCI88845 PMID:28287406 PMCID:PMC5373891
  • Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen C, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. 2017. Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease. Cell Metab 25(5):1054-1062.e5. doi:10.1016/j.cmet.2017.04.001 PMID:28467925 PMCID:PMC550273
  • Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Valasek MA, Rizo E, Brenner DA, Sirlin CB, Loomba R. 2017. Magnetic resonance elastography vs transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease. Gastroenterology 152(3):598-607.e2. doi:10.1053/j.gastro.2016.10.026 PMID:27911262 PMCID:PMC5285304
  • Reinders ME, Wardi G, Bettencourt R, Bouland D, Bazick J, Mendler M, Vodkin I, Kalmaz D, Savides T, Brenner DA, Sell RE, Loomba R. 2017. Increased risk of death, in the hospital and outside the intensive care unit, for patients with cirrhosis after cardiac arrest. Clin Gastroenterol Hepatol 15(11):1808-1810. doi:10.1016/j.cgh.2017.05.044 PMID:28602970 PMCID:PMC5723019
  • Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner DA, Duffield J, Burkly LC. 2017. Identification of novel fibrosis modifiers by in vivo siRNA silencing. Mol Ther Nucleic Acids 7:314-323. doi:10.1016/j.omtn.2017.04.014 PMID:28624207 PMCID:PMC5424569
  • Xu J, Ma H, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. 2017. The role of human CYP2E1 in liver inflammation and fibrosis. Hepatol Commun 1:1043-1057. doi:10.1002/hep4.1115 PMID:29404441 PMCID:PMC572140

2016

2015

2014

  • Inokuchi-Shimizu S, Park E, Roh Y, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky J, Karin M, Brenner DA, Seki E. 2014. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest 124(8):3566-3578. doi:10.1172/JCI74068 PMID:24983318 PMCID:PMC4109552
  • Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E. 2014. Transcriptional repression of the transforming growth factor β (TGF-β) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 enhances TGF-β signaling in hepatic stellate cells. J Biol Chem 289(10):7082-7091. doi:10.1074/jbc.M113.543769 PMID:24448807 PMCID:PMC3945368
  • Lopez-Sanchez I, Dunkel Y, Roh Y, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P. 2014. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun 5:4451. doi:10.1038/ncomms5451 PMID:25043713 PMCID:PMC4107319
  • Paik Y, Kim J, Aoyama T, De Minicis S, Bataller R, Brenner DA. 2014. Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal 20(17):2854-2872. doi:10.1089/ars.2013.5619 PMID:24040957 PMCID:PMC4026397
  • Schnabl B, Brenner DA. 2014. Interactions between the intestinal microbiome and liver diseases. Gastroenterology 146(6):1513-1524. doi:10.1053/j.gastro.2014.01.020 PMID:24440671 PMCID:PMC3996054
  • Seki E, Brenner DA. 2014. NF-kB. In: Signaling Pathways in Liver Diseases. Wiley-Blackwell, Oxford, England.

2013

  • Madsen DH, Leonard D, Masedunskas A, Moyer A, Jurgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH. 2013. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol 202(6):951-966. doi:10.1083/jcb.201301081 PMID:24019537 PMCID:PMC3776354

2012

2011

  • Osterreicher C, Penz-Osterreicher M, Grivennikov S, Guma M, Koltsova E, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. 2011. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 108(1):308-313. doi:10.1073/pnas.1017547108 PMID:21173249 PMCID:PMC3017162
Back
to Top
Last Reviewed: September 05, 2024