Superfund Research Program
Nuclear Receptor Mediated Epigenetic and Immune Cell Changes in Liver Fibrosis Resulting From Toxicant Exposure
Project Leader: Ronald M. Evans (Salk Institute for Biological Studies)
Co-Investigator: Michael Downes (Salk Institute for Biological Studies)
Grant Number: P42ES010337
Funding Period: 2017-2023
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Title: The nuclear receptor REV-ERBalpha modulates Th17 cell-mediated autoimmune disease
Accession Number: PRJNA293472
Link to Dataset: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA293472
Repository: BioProject
Data Type(s): Gene Expression, Genome Sequences
Experiment Type(s): Transcriptome or gene expression
Organism(s): Mus musculus
Summary: To evaluate the effects of ectopic expression of REV-ERBs in Th17 cells at a genome-wide scale, we performed RNA-sequencing analysis of Th17 cells retrovirally transduced with REV-ERBalpha, REV-ERBbeta or MigR1 control vector.