Superfund Research Program

Michael Downes

Salk Institute for Biological Studies
10010 North Torrey Pines Road
La Jolla, California 92037-1099
Phone: 858-453-4100 x1862
Email: downes@salk.edu

Projects

• University of California-San Diego: Nuclear Receptor Mediated Epigenetic and Immune Cell Changes in Liver Fibrosis Resulting From Toxicant Exposure (2017-2023)

Patents

• Chimeric Fibroblast Growth Factor (FGF) 2/FGF1 Peptides and Methods of Use
• Chimeric Fibroblast Growth Factor (FGF) 2/FGF1 Peptides and Methods of Use
• Chimeric Fibroblast Growth Factor (FGF) 2/FGF1 Peptides and Methods of Use
• Chimeric Fibroblast Growth Factor (FGF) 2/FGF1 Peptides and Methods of Use
• Chimeric Fibroblast Growth Factor (FGF) 2/FGF1 Peptides and Methods of Use
• Chimeric Fibroblast Growth Factor (Fgf) 2/Fgf1 Peptides And Methods Of Use
• Chimeric Fibroblast Growth Factor (Fgf) 2/Fgf1 Peptides And Methods Of Use
• Chimeric Fibroblast Growth Factor 1 Protein Fragments and Methods of Use
• Chimeric Fibroblast Growth Factor 19 Proteins and Methods of Use
• Chimeric Fibroblast Growth Factor 19 Proteins and Methods of Use
• Chimeric Fibroblast Growth Factor 19 Proteins and Methods of Use
• Chimeric Fibroblast Growth Factor 21 Proteins and Methods of Use
• Chimeric Fibroblast Growth Factor 21 Proteins and Methods of Use
• Chimeric Fibroblast Growth Factor 21 Proteins and Methods of Use
• FGF2 Truncations and Methods of Use Thereof
• Increasing Storage of Vitamin A, Vitamin D, and/or Lipids
• Increasing Storage of Vitamin A, Vitamin D, and/or Lipids
• Increasing Storage of Vitamin A, Vitamin D, and/or Lipids
• Mutated Fibroblast Growth Factor (FGF) 1 and Methods of Use
• Mutated Fibroblast Growth Factor (FGF) 1 and Methods of Use
• Mutated Fibroblast Growth Factor (FGF) 1 and Methods of Use
• Mutated Fibroblast Growth Factor (FGF) 1 and Methods of Use
• Mutated Fibroblast Growth Factor (FGF1) and Methods of Use
• Mutated Fibroblast Growth Factor (FGF1) and Methods of Use
• Mutated Fibroblast Growth Factor (FGF1) and Methods of Use

Publications

2023

• Antal CE, Oh TG, Aigner S, Luo E, Yee BA, Campos T, Tiriac H, Rothamel KL, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banayo E, Bashi S, Esparza E, Munoz RM, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DD, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. 2023. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. Nat Commun 14(1):5195. doi:10.1038/s41467-023-40798-6 PMID:37673892 PMCID:PMC10482938
• Billon C, Situala S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. 2023. Synthetic ERRalpha/beta/gamma agonist induces an ERRalpha- dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem Biol 18(4):756-771. doi:10.1021/acschembio.2c00720 PMID:36988910
• Kushwaha P, Tran A, Quintero D, Song M, Yu Q, Yu RT, Downes M, Evans RM, Babst-Kostecka AA, Schroeder JI, Maier RM. 2023. Zinc accumulation in Atriplex lentiformis is driven by plant genes and the soil microbiome. Sci Total Environ 899:165667. doi:10.1016/j.scitotenv.2023.165667 PMID:37478925

2022

• Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang L, Vogel I, Zhou C, Nguyen V, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Alexander LE, Suh J, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee I, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. 2022. Obesity alters pathology and treatment response in inflammatory disease. Nature 604:337-342. doi:10.1038/s41586-022-04536-0 PMID:35355021
• Fu T, Li Y, Oh TG, Cayabyab F, He N, Tang Q, Coulter S, Truitt ML, Medina P, He M, Yu RT, Atkins AR, Zheng Y, Liddle C, Downes M, Evans RM. 2022. FXR mediates ILC-intrinsic responses to intestinal inflammation. Proc Natl Acad Sci U S A 119(51):e2213041119. doi:10.1073/pnas.2213041119 PMID:36508655
• Huang DQ, Downes M, Evans RM, Witzum JL, Glass CK, Loomba R. 2022. Shared mechanisms between cardiovascular disease and NAFLD. Semin Liver Dis 42(4):455-464. doi:10.1055/a-1930-6658 PMID:36008083 PMCID:PMC9828940
• Kim J, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. 2022. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab 34(10):1548-1560. doi:10.1016/j.cmet.2022.08.005 PMID:36041455 PMCID:PMC9547947
• Sancar G, Liu S, Gasser E, Alvarez JG, Moutos CP, Kim K, van Zutphen T, Wang Y, Huddy T, Ross B, Dai Y, Zepeda D, Collins B, Tilley E, Kolar MJ, Yu RT, Atkins AR, van Dijk TH, Saghatelian A, Jonker JW, Downes M, Evans RM. 2022. FGF1 and insulin control lipolysis by convergent pathways. Cell Metab 34(1):171-183. doi:10.1016/j.cmet.2021.12.004 PMID:34986332 PMCID:PMC886306
• Sharpton S, Oh TG, Madamba E, Wang C, Yu RT, Atkins AR, Huan T, Downes M, Evans RM, Loomba R. 2022. Gut metagenome-derived signature predicts hepatic decompensation and mortality in NAFLD-related cirrhosis. Aliment Pharmacol Ther doi:10.1111/apt.17236 PMID:36164267

2021

• Abu-Odeh M, Zhang Y, Reilly SM, Ebadat N, Keinan O, Valentine JM, Hafezi-Bakhtiari M, Ashayer H, Mamoun L, Zhou X, Zhang J, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Kliewer SA, Mangelsdorf DJ, Saltiel AR. 2021. FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. Cell Rep 35:109331. doi:10.1016/j.celrep.2021.109331 PMID:34192547
• Iwamoto M, Masuya T, Hosose M, Tagawa K, Ishibashi T, Suyama K, Nose T, Yoshihara E, Downes M, Evans RM, Matsushima A. 2021. Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor B. J Biol Chem 297(5):doi:10.1016/j.jbc.2021.101173 PMID:34499926 PMCID:PMC8551653
• Wang L, Oh TG, Magida J, Estepa G, Obayomi SB, Chong L, Gatchalian J, Yu RT, Atkins AR, Hargreaves D, Downes M, Wei Z, Evans RM. 2021. Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. Proc Natl Acad Sci U S A 118(35):e2109517118. doi:10.1073/pnas.2109517118 PMID:34446564 PMCID:PMC8536317
• Xu SA, Chaudhary O, Rodriguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AF, Williams A, Schulze I, Farsakoglu Y, Varanasi SK, Low JS, Tang W, Wang H, McDonald B, Tripple V, Downes M, Evans RM, Abumrad NA, Merghoub T, Wolchok JD, Shokhirev MN, Ho P, Witztum JL, Emu B, Cui G, Kaech SM. 2021. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8(+) T cells in tumors. Immunity 54:1561-1577. doi:10.1016/j.immuni.2021.05.003 PMID:34102100
• Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. 2021. Immune-evasive human islet-like organoids ameliorate diabetes. Nature 590:doi:10.1038/s41586-020-03109-3 PMID:33469222
• Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li S, Welch R, Huang F, Qi L, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu E, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. 2021. Intestinal a1-2-fucosylation contributes to obesity and steatohepatitis in mice. Cell Mol Gastroenterol Hepatol 12(1):doi:10.1016/j.jcmgh.2021.02.009 PMID:33631374 PMCID:PMC8166943

2020

• Lenkiewicz E, Malasi S, Hogenson TL, Flores LF, Barham W, Phillips WJ, Roesler AS, Chambers KR, Rajbhandari N, Hayashi A, Antal CE, Downes M, Grandgenett PM, Hollingsworth MA, Cridebring D, Xiong Y, Lee J, Ye Z, Yan H, Hernandez MC, Leiting JL, Evans RM, Ordog T, Truty MJ, Borad MJ, Reya T, Von Hoff DD, Fernandez-Zapico ME, Barrett MT. 2020. Genomic and epigenomic landscaping defines new therapeutic targets for adenosquamous carcinoma of the pancreas. Cancer Res 80:4324-4334. doi:10.1158/0008-5472.CAN-20-0078 PMID:32928922
• Noel P, Hussein S, Ng S, Antal CE, Lin W, Rodela E, Delgado P, Naveed S, Downes M, Lin Y, Evans RM, Von Hoff DD, Han H. 2020. Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts. Oncogenesis 9(100):doi:10.1038/s41389-020-00285-9 PMID:33168807 PMCID:PMC7653036
• Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba E, Bettencourt R, Richards L, Raffatellu M, Dorrestein PC, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin C, Knight R, Downes M, Evans RM, Loomba R. 2020. A universal gut-microbiome-derived signature predicts cirrhosis. Cell Metab 32:doi:10.1016/j.cmet.2020.10.015 PMID:33147487 PMCID:PMC7891106 (accepted for publication)
• Quinn RA, Melnik A, Vrbanac AF, Fu T, Patras K, Christy M, Bodai Z, Belda-Ferre P, Tripathi A, Chung L, Downes M, Welch R, Quinn M, Humphrey G, Panitchpakdi M, Weldon K, Aksenov AA, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa E, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz J, Meehan M, Gentry E, Arthur T, Komor A, Poulsen O, Boland BS, Chang JT, Sandborn W, Lim M, Garg N, Lumeng J, Xavier R, Kazmierczak B, Jain R, Egan M, Rhee K, Ferguson D, Raffatellu M, Vlamakis H, Haddad G, Siegel D, Huttenhower C, Mazmanian S, Evans RM, Nizet V, Knight R, Dorrestein PC. 2020. Global chemical effects of the microbiome include new bile-acid conjugations. Nature 579:123-129. doi:10.1038/s41586-020-2047-9 PMID:32103176
• Sun X, Seidman J, Zhao P, Troutman T, Spann N, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida J, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. 2020. Neutralization of oxidized phospholipids ameliorates non-alcoholic steatohepatitis. Cell Metab 31(1):189-206. doi:10.1016/j.cmet.2019.10.014 PMID:31761566 PMCID:PMC7028360

2019

• Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R, Rizo E, Richards L, Xu Z, Downes M, Evans RM, Brenner DA, Sirlin CB, Knight R, Loomba R. 2019. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat Commun 10:1406. doi:10.1038/s41467-019-09455-9 PMID:30926798 PMCID:PMC6440960
• Chang C, Loo C, Zhao X, Solt LA, Liang Y, Bapat SP, Cho H, Kamenecka TM, Leblanc M, Atkins AR, Yu RT, Downes M, Burris TP, Evans RM, Zheng Y. 2019. The nuclear receptor REV-ERB alpha modulates Th17 cell-mediated autoimmune disease. Proc Natl Acad Sci U S A 116:18528-18536. doi:10.1073/pnas.1907563116 PMID:31455731 PMCID:PMC6744854
• Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM. 2019. FXR regulates intestinal cancer stem cell proliferation. Cell 176:1098-1112. doi:10.1016/j.cell.2019.01.036 PMID:30794774 PMCID:PMC6701863
• Wang L, Mazagova M, Pan C, Yang S, Brandl KL, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. 2019. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A 116:15184-15193. doi:10.1073/pnas.1904360116 PMID:31289229 PMCID:PMC6660779

2018

• Ahmadian M, Liu S, O'Reilly S, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. 2018. ERR gamma preserves brown fat innate thermogenic activity. Cell Rep 22(11):2849-2859. doi:10.1016/j.celrep.2018.02.061 PMID:29539415 PMCID:PMC5884669
• Fan W, He N, Lin CS, Wei Z, Hah N, Waizenegger W, He M, Liddle C, Yu RT, Atkins AR, Downes M, Evans RM. 2018. ERRgamma promotes angiogenesis, mitochondrial biogenesis, and oxidative remodeling in PGC1alpha/beta-deficient muscle. Cell Rep 22:2521-2529. doi:10.1016/j.celrep.2018.02.047 PMID:29514081 PMCID:PMC5860878
• Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Starkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. 2018. Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. Hepatology doi:10.1002/hep.29676 PMID:29159825 PMCID:PMC5962369
• Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto AF, Huddy T, Wang Y, Ross B, Estepa G, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM. 2018. Vitamin D Switches BAF Complexes to Protect Beta Cells. Cell 173:1135-1149. doi:10.1016/j.cell.2018.04.013 PMID:29754817 PMCID:PMC5987229

2017

• Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin D, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong L, Cho H, Xie J, Li Q, Muschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP. 2017. Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A 114(47):12548-12553. doi:10.1073/pnas.1619119114 PMID:29109286 PMCID:PMC5703267
• Doktorova M, Zwarts I, van Zutphen T, van Dijk TH, Bloks VW, Harkema L, de Bruin A, Downes M, Evans RM, Verkade HJ, Jonker JW. 2017. Intestinal PPARdelta protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep 7:846. doi:10.1038/s41598-017-00889-z PMID:28404991
• Fan W, Waizenegger W, Lin CS, Sorrentino V, He M, Wall CE, Li H, Liddle C, Yu RT, Atkins AR, Auwerx J, Downes M, Evans RM. 2017. PPARdelta promotes running endurance by preserving glucose. Cell Metab 25:1186-1193.e4. doi:10.1016/j.cmet.2017.04.006 PMID:28467934 PMCID:PMC549297
• He N, Fan W, Henriquez B, Yu RT, Atkins AR, Liddle C, Zheng Y, Downes M, Evans RM. 2017. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. Proc Natl Acad Sci U S A 114(47):12542-12547. doi:10.1073/pnas.1715363114 PMID:29109251 PMCID:PMC5703326
• Shalapour S, Lin X, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner CW, Anstee QM, Karin M. 2017. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551(7680):340-345. doi:10.1038/nature24302 PMID:29144460 PMCID:PMC5884449
• Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q. 2017. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. Nat Commun 8(1):959. doi:10.1038/s41467-017-00931-8 PMID:29038463 PMCID:PMC5643384
• Wu C, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM. 2017. Structural basis for specific ligation of the peroxisome proliferater-activated receptor delta. Proc Natl Acad Sci U S A 114:13:E2563-2570. doi:10.1073/pnas.1621513114 PMID:28320959 PMCID:PMC5380080

2016

• Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng TW, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. 2016. ERRγ is required for the metabolic maturation of therapeutically functional glucose-responsive β cells. Cell Metab 23(4):622-634. doi:10.1016/j.cmet.2016.03.005 PMID:27076077 PMCID:PMC4832237

2015

• Bapat SP, Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, Leblanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528(7580):137-141. doi:10.1038/nature16151 PMID:26580014 PMCID:PMC4670283
• Ding N, Hah N, Yu RT, Sherman MH, Benner CW, Leblanc M, He M, Liddle C, Downes M, Evans RM. 2015. BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A 112(51):15713-15718. doi:10.1073/pnas.1522163112 PMID:26644586 PMCID:PMC4697417
• Fang S, Suh J, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky J, Saltiel AR, Downes M, Evans RM. 2015. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med 21(2):159-165. doi:10.1038/nm.3760 PMID:25559344 PMCID:PMC4320010
• Hah N, Benner CW, Chong L, Yu RT, Downes M, Evans RM. 2015. Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. Proc Natl Acad Sci U S A 112(3):E297-E302. doi:10.1073/pnas.1424028112 PMID:25564661 PMCID:PMC4311831
• Suh J, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin Y, Yu RT, Liddle C, Atkins AR, Olefsky J, Mohammadi M, Downes M, Evans RM. 2015. Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature 520(7547):388. doi:10.1038/nature14304 PMID:25739500 PMCID:PMC4184286

2014

• Hong S, Ahmadian M, Yu RT, Atkins AR, Downes M, Evans RM. 2014. Nuclear receptors and metabolism: from feast to famine. Diabetologia 57(5):860-867. doi:10.1007/s00125-014-3209-9 PMID:24619218 PMCID:PMC3980036
• Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. 2014. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 159(1):80-93. doi:10.1016/j.cell.2014.08.007 PMID:25259922 PMCID:PMC4177038
• Zhao X, Cho H, Yu RT, Atkins AR, Downes M, Evans RM. 2014. Nuclear receptors rock around the clock. EMBO J 15(5):518-528. doi:10.1002/embr.201338271 PMID:24737872 PMCID:PMC4210094

2013

• Ahmadian M, Suh J, Hah N, Liddle C, Atkins AR, Downes M, Evans RM. 2013. PPAR gamma signaling and metabolism: the good, the bad and the future. Nat Med 19:557-566. doi:10.1038/nm.3159 PMID:23652116 PMCID:PMC3870016
• Ding N, Yu RT, Subramaniam N, Sherman MH, Wilson C, Rao R, Leblanc M, Coulter S, He M, Scott C, Lau SL, Atkins AR, Barish GD, Gunton JE, Liddle C, Downes M, Evans RM. 2013. A vitamin D receptor / SMAD genomic circuit gates hepatic fibrotic response. Cell 153(3):601-613. doi:10.1016/j.cell.2013.03.028 PMID:23622244 PMCID:PMC3673534
• Du L, Bergsneider M, Mirsadraei L, Young SH, Jonker JW, Downes M, Yong WH, Evans RM, Heaney AP. 2013. Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease. Proc Natl Acad Sci U S A 110:8555-8560. doi:10.1073/pnas.1306182110 PMID:23653479 PMCID:PMC3666748
• Fan W, Atkins AR, Yu RT, Downes M, Evans RM. 2013. Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J Mol Endocrinol 51(3):T87-T100. doi:10.1530/JME-13-0258 PMID:24280961 PMCID:PMC3936671
• Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W. 2013. Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation. Pharm Res 30(9):2199-2208. doi:10.1007/s11095-013-1101-9 PMID:23896737 PMCID:PMC3771640
• Uhlenhaut N, Barish GD, Yu RT, Downes M, Karunasiri M, Liddle C, Schwalie P, Hubner N, Evans RM. 2013. Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol Cell 49(1):158-171. doi:10.1016/j.molcel.2012.10.013 PMID:23159735 PMCID:PMC3640846

2012

• Jonker JW, Liddle C, Downes M. 2012. FXR and PXR: Potential therapeutic targets in cholestasis. Psychiatr Pol 130(3-5):147-158. doi:10.1016/j.jsbmb.2011.06.012 PMID:21801835 PMCID:PMC4750880
• Li T, Yu RT, Atkins AR, Downes M, Tukey RH, Evans RM. 2012. Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets 16(11):1075-1083. doi:10.1517/14728222.2012.715634 PMID:22913318 PMCID:PMC4319648

2011

• Kacevska M, Downes M, Sharma R, Evans RM, Clarke SJ, Liddle C, Robertson GR. 2011. Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. Clin Cancer Res 17:3170-3180. doi:10.1158/1078-0432.ccr-10-3289 PMID:21498392 PMCID:PMC3096719

2006

• Stedman C, Liddle C, Coulter S, Sonoda J, Alvarez JG, Evans RM, Downes M. 2006. Benefit of farnesoid X receptor inhibition in obstructive cholestasis. Proc Natl Acad Sci U S A 103(30):11323-11328. PMID:16844773