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Duke University: Dataset Details, ID=GSE144573

Superfund Research Program

Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation

Center Director: Heather M. Stapleton
Grant Number: P42ES010356
Funding Period: 2000-2027
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Title: Effect of knocking down complex I subunit nuo-5 (ortholog of the human NDUFS1) in C.elegans

Accession Number: GSE144573

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE144573

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by array

Organism(s): Caenorhabditis elegans

Summary: In this study we compared the transcriptomic profile in control L3 larvae with that of mild or strong (arrested) nuo-5 RNAi. The two treatment (mild and strong) in fact lead to two very different phenotype. The mild supperssion of nuo-5 induces improved healthspand and has pro longevity effect. The strong suppression of the same gene has, on the contrary, deleterious effects such as arrested development.

Publication(s) associated with this dataset:
  • Maglioni S, Schiavi A, Melcher M, Brinkmann V, Luo Z, Laromaine A, Raimundo N, Meyer JN, Distelmaier F, Ventura N. 2022. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Nat Commun doi:10.1038/s41467-022-29972-4 PMID:35551180 PMCID:PMC9098500
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