Superfund Research Program
Zebrafish as a Detector and Discriminator of Organophosphate Exposure
Project Leaders: Elwood A. Linney (Duke University Medical Center), Richard T. Di Giulio
Grant Number: P42ES010356
Funding Period: 2000-2011
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Title: AB* zebrafish embryos exposed to 1 ng/mL TCDD from 1d to 5d post-fertilization.
Accession Number: GSE15410
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE15410
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Expression profiling by array
Organism(s): Danio rerio
Summary: Transcriptomic profiling of the response to dioxin in developing zebrafish embryos, at 24, 48, 72, 96, and 120 h post-fertilization. The goal was to elucidate mechanisms by which dioxin causes toxicity in zebrafish; this dose was previously shown to induce teratogenesis.
Publication(s) associated with this dataset:- Alexeyenko A, Wassenberg DM, Lobenhofer EK, Yen J, Linney EA, Sonnhammer E, Meyer JN. 2010. Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. PLoS One 5(5):e10465. doi:10.1371/journal.pone.0010465 PMID:20463971 PMCID:PMC2864754