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Your Environment. Your Health.

Brown University: Dataset Details, ID=PRJNA492909

Superfund Research Program

Toxicant Exposures in Rhode Island: Past, Present, and Future

Center Director: Robert H. Hurt
Grant Number: P42ES013660
Funding Period: 2005-2021
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Title: Small RNA sequencing analysis of sperm RNA after control, and 3 different dose treatments of ethylene glycol monomethyl ether.

Accession Number: PRJNA492909

Link to Dataset:

Repository: BioProject

Data Type(s): Epigenetic Data

Experiment Type(s): Raw sequence reads

Organism(s): Rattus norvegicus

Summary: This study was designed to identify molecular biomarkers in the sperm of rats treated with a known testicular toxicant. Here, we exposed rats to a model testicular toxicant, ethylene glycol monomethyl ether, that negatively affects a sperm precursor cell. We waited for these cells to become sperm, and then used RNA sequencing to look at the whole population of small RNAs. Changes in these small RNAs may be used to predict testicular toxicity in clinical or pharmaceutical testing settings. These RNAs may also be associated with paternal epigenetic inheritance of disease, or toxicity. In these instances, the father may pass non-genetically based health problems to offspring through sperm, or may have unintended health effects in offspring due to the father being exposures to environmental contaminants or pharmaceutical compounds.

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