Superfund Research Program
Data Management and Analysis Core
Project Leader: Katrina M. Waters (Pacific Northwest National Laboratory)
Co-Investigator: Sara Gosline (Pacific Northwest National Laboratory)
Grant Number: P42ES016465
Funding Period: 2009-2025
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Title: mRNA and miRNA expression analysis of developmental ethanol exposure in zebrafish
Accession Number: GSE30497
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE30497
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Expression profiling by array
Organism(s): Danio rerio
Summary: During early neurogenesis, multiple whole animal gene expression profiling studies revealed widespread changes in developmental mRNA and miRNA abundance in ethanol-exposed embryos. Consistent with a role for miRNAs in neurobehavioral development, miRNA target prediction analyses identified multiple miRNAs misexpressed in the ethanol exposed cohorts that were also predicted to target inversely expressed transcripts known to influence brain morphogenesis.
Publication(s) associated with this dataset:- Tal TL, Franzosa JA, Tilton SC, Philbrick KA, Iwaniec UT, Turner RT, Waters KM, Tanguay RL. 2012. MicroRNAs control neurobehavioral development and function in zebrafish. FASEB J 26(4):1452-1461. doi:10.1096/fj.11-194464 PMID:22253472 PMCID:PMC3316906