Superfund Research Program
Statistics and Bioinformatics Research Support Core
Project Leader: Katrina M. Waters (Pacific Northwest National Laboratory)
Grant Number: P42ES016465
Funding Period: 2009-2019
Project Summary (2009-2013)
The Statistics and Bioinformatics Core provides project investigators with expert collaboration for consultative statistics and bioinformatics, software for data management, and customized analysis workflows through connectivity to essential tools for data interpretation. This Core provides computational capabilities that many of the Research Projects need and, through the centralized support, facilitates data integration and dissemination across all projects. The objective of this Core is to provide data management and analysis through three primary goals:
- statistics for experimental design, biomarker discovery and multivariate data analyses,
- bioinformatics for reconstruction of regulatory pathways, cross-species extrapolations and data integration across projects, and
- integrated data storage and management software on a computational infrastructure to support data intensive mining and analysis methods.
The Core provides expertise from a multi-disciplinary team with expertise in statistics, bioinformatics and computer science to bring the best methods and software available to the research projects and Cores. The centralized data management organization also promotes data sharing across research projects and facilitates the dissemination of data to public databases, such as the NIEHS Chemical Effects in Biological Systems Knowledge Base and NCBI's Gene Expression Omnibus. This Core also provides training opportunities for post-doctoral fellows in the Program to cross-train in statistics and bioinformatics.