Superfund Research Program
Research Briefs By Category: Epidemiology
- 273 - Susceptibility to Arsenic-Induced Skin Lesions Influenced by DNA Differences -- Ahsan
Release Date: 09/06/2017
New research shows that deletions or duplications of long stretches of DNA, also known as copy number variations (CNVs), that occur in several gene locations are associated with a higher risk of developing arsenic-induced skin lesions. Skin lesions are a hallmark of arsenic toxicity that appear relatively early with chronic arsenic exposure. This newly discovered link may help to explain why some people exposed to arsenic develop skin lesions and get sick while others exposed to the same levels do not.
- 270 - Prenatal PCE Exposure and Maternal Alcohol Use Linked to Increased Risks of Teenage Drug Use -- Aschengrau
Release Date: 06/07/2017
Prenatal exposure to both alcohol and tetrachloroethylene, also known as perchloroethylene or PCE, may increase the risk of using multiple illicit drugs as a teenager, according to a study by Boston University Superfund Research Program (BU SRP) Center researchers. PCE is a solvent frequently used in dry cleaning solutions, adhesives, metal degreasers, and other commercial products.
- 247 - PCE in Drinking Water Linked to Cancer and Epilepsy -- Aschengrau
Release Date: 07/01/2015
Early-life exposure to tetrachloroethylene (PCE; perchloroethylene) in drinking water may increase the risk of epilepsy and certain types of cancer into adulthood, according to Boston University Superfund Research Program (BU SRP) Center researchers. PCE is a solvent frequently used in dry cleaning solutions, adhesives, metal degreasers, and other commercial products.
- 240 - Linking Phthalate Exposure and Oxidative Stress in Pregnancy -- Meeker
Release Date: 12/03/2014
In a recent study from the University of Michigan School of Public Health, NIEHS Superfund Research Program (SRP), scientists reported that in pregnant women, exposure to phthalates, found in plastics and personal care products, was associated with increased levels of oxidative stress, which damages the body's proteins, lipids, and DNA. The findings may help scientists better understand the mechanisms involved in pregnancy complications, such as preterm birth, which are associated with exposure to phthalates.
- 235 - Reducing the Risk of PCB-associated Type 2 Diabetes with Fruit and Vegetable Consumption -- Gaetke
Release Date: 07/02/2014
Adults with high levels of polychlorinated biphenyls (PCBs) in their bodies, which may increase the risk of developing type 2 diabetes, can reduce that risk by eating more fruits and vegetables, according to researchers from the University of Kentucky Superfund Research Program (UK SRP).
- 233 - Investigating the Newborn Proteome: Prenatal Arsenic Exposure and Altered Protein Expression -- Fry
Release Date: 05/07/2014
Scientists have identified changes in biological pathways that are associated with prenatal arsenic exposure. This research, led by Rebecca Fry, Ph.D., at the University of North Carolina Superfund Research Program (UNC SRP), is the largest protein-based study of an arsenic pregnancy cohort to date. The NIEHS-funded work provides mechanistic insights into the links between early life exposure to arsenic and disease susceptibility and also identifies proteins and pathways that may later be used to identify markers of arsenic exposure and disease risk in humans.
- 228 - Arsenic in Drinking Water and Cancer in Uniquely Exposed Northern Chile -- Steinmaus
Release Date: 12/04/2013
For the first time, findings by the University of California (UC) Berkeley Superfund Research Program (SRP) provide strong evidence in humans that ingested arsenic causes cancer in specific kidney and ureter cells, called transitional cells. Other recent findings from the group suggest that people exposed to both arsenic and other known or suspected carcinogens have very high risks of lung or bladder cancer.
- 223 - Nicotine in Peppers and Other Vegetables May Reduce Parkinson Disease Risk -- Checkoway, Searles Nielsen
Release Date: 07/03/2013
Eating nicotine-containing vegetables, mainly peppers, may provide a protective effect against Parkinson disease (PD). Based on studies consistently suggesting that smokers are less likely than non-smokers to develop PD, Susan Searles Nielsen, Ph.D., led a study to explore other sources of nicotine that might have effects similar to active smoking, such as vegetables from the same plant family as tobacco.
- 217 - Majority of Women Exposed to Multiple Pollutants -- Thompson
Release Date: 01/02/2013
According to a new analysis of thousands of U.S. women of child bearing age, most exceeded the median blood level for two or more environmental pollutants - lead, mercury, and polychlorinated biphenyls (PCBs) - that are known to harm brain development of fetuses and infants.
- 215 - Study Links Prenatal Mercury Exposure and Fish Intake to ADHD-Related Behavior -- Korrick
Release Date: 11/07/2012
A new study suggests an association between low-level mercury exposure and an increased risk of attention-deficit/hyperactivity disorder (ADHD)-related behaviors. Conversely, children whose mothers ate more fish, the main non-occupational source of mercury exposure, during pregnancy had a lower risk of exhibiting ADHD-related behaviors.
- 212 - Early-life PCE Exposure Linked to Visual Impairment in Adults -- Aschengrau
Release Date: 08/01/2012
New evidence shows exposure to the chemical PCE during development can lead to visual impairment later in life. Scientists have previously linked the chemical with neurological effects like memory and attention problems.
- 208 - A Flurry of Arsenic Findings -- Jackson, Lu, Ahsan
Release Date: 04/04/2012
New evidence about arsenic abounds in SRP studies published recently. The studies reveal that food is an unexpected source of arsenic exposure, demonstrate adverse health effects are from low levels of exposure, show the mechanisms behind some of arsenic's health effects, and suggest a strategy for reducing exposure from well water.
- 203 - Research Shows Arsenic Attaches to Sediments, Protects Human Health -- van Geen
Release Date: 11/02/2011
Scientists find arsenic can attach to sediments around deep wells, potentially reducing the risk of arsenic exposure for water users. The finding has implications for how arsenic-contaminated water sources are treated and managed.
- 202 - Size-resolved Chemical Characterization of Atmospheric Aerosols -- Betterton
Release Date: 10/05/2011
Some mining operations release dust containing hazardous elements like arsenic and lead into the air. Scientists have developed a new approach for detecting these airborne pollutants, assessing their potential health impacts and reducing human exposures.
- 190 - Determining Susceptibility to Environmentally-induced Neurotoxicity -- Furlong
Release Date: 10/05/2010
Researchers use an innovative approach to track the health effects of organophosphate insecticides. The findings may also have implications for research on Parkinson's disease and studies on the health effects of nerve agents and aircraft engine fumes.
- 189 - Use of Spatial and Temporal Analyses to Provide Insights into the Environmental Etiology of Cancer -- Aschengrau, Webster
Release Date: 09/01/2010
Scientists are investigating what individuals in geographic "hot spots" for cancer have in common to reveal possible routes of exposure to environmental carcinogens.
- 178 - Arsenic Just as Risky Ingested as Inhaled -- Smith
Release Date: 10/07/2009
- 174 - Gene-Environment Interactions: PCB Exposures and Adverse Effects on Pregnancy -- Sharma
Release Date: 06/03/2009
- 173 - Are There Links Between Selenium Intake and Bladder Cancer? -- Karagas
Release Date: 05/06/2009
- 137 - Impacts of in utero and Early Childhood Exposure to Arsenic in Drinking Water -- Smith
Release Date: 05/03/2006
- 129 - Manganese Exposure via Drinking Water and Children's Intellectual Function -- Graziano
Release Date: 09/07/2005
- 125 - Epidemiologic Research on Environmental Pollution and the Risk of Disease -- Aschengrau
Release Date: 05/04/2005
- 121 - Impacts of Low-Level Benzene Exposure -- Smith, Rappaport
Release Date: 01/05/2005
- 120 - Arsenic Exposure via Drinking Water and Children's Intellectual Function -- Graziano
Release Date: 12/01/2004
- 99 - The Role of Gene/Environment Interactions in the Etiology of Parkinson's Disease -- Checkoway
Release Date: 03/05/2003
- 97 - The Harvard-Mexico Project on Maternal-Fetal Lead Exposure, Risks, and Prevention -- Hu
Release Date: 01/02/2003
- 95 - Multidisciplinary Studies of the Origins of Childhood Leukemia -- Smith, Buffler
Release Date: 11/06/2002
- 76 - Low Dose Arsenic Exposures Related to Skin Cancer -- Karagas
Release Date: 04/04/2001
- 72 - An Investigation of the Behavioral Toxicity of Lead -- Strupp
Release Date: 12/06/2000
- 71 - A Partnership Study of the Effects of PCBs on Akwesasne Mohawk Youth -- Schell
Release Date: 11/01/2000
- 59 - New Mapping Method is Developed for Analysis of Environmental Epidemiological Data -- Ozonoff
Release Date: 11/17/1999
- 57 - Development of Biomarkers for Male Reproductive Toxicity and Their Implications for Male-Mediated Developmental Toxicity -- Wyrobek, Eskenazi
Release Date: 10/20/1999
- 54 - Investigating the Human Health Effects of Vanadium -- Recent Studies Show Significant Acute Respiratory Effects in Occupationally-Exposed Workers, Even at Permissible Exposure Limits -- Christiani
Release Date: 09/08/1999
- 35 - Organochlorine Exposure and Breast Cancer Risk -- Grandjean
Release Date: 12/09/1998
- 17 - In Utero PCB Exposures and Infant Development -- Korrick
Release Date: 04/01/1998
- 7 - New Methods of Spatial Analysis Are Developed for Environmental Epidemiological Data Using a Geographic Information System -- Ozonoff
Release Date: 10/29/1997
- 5 - Studies Determine Factors That Contribute to Bone Lead Accumulation and Release -- Hu
Release Date: 10/01/1997