Superfund Research Program
UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research Program
Center Director: Jose Manuel Cerrato
Grant Number: P42ES025589
Funding Period: 2017-2027
Program Links
Datasets
Hazardous Waste Sites
News Items
Patents
Publications
Research BriefsConnect with the Grant Recipients
Title: Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice
Accession Number: doi:10.6073/pasta/00830d488944eaddf25b89ebb86cebf0
Link to Dataset: https://portal.edirepository.org/nis/mapbrowse?packageid=edi.459.1
Repository: EDI Data Portal (Environmental Data Initiative)
Data Type(s): Exposure Data
Organism(s): Mus musculus
Summary: High levels of uranium (U) exist in soil, water, and air in the Southwestern United States due, in part, to waste generated from more than 160,000 abandoned hard rock mines located in this region. As a result, many people living in this region are chronically exposed to U at levels that have been linked to detrimental health outcomes. In an effort to establish a relevant in vivo mouse model for future U immunotoxicity studies, we evaluated the tissue distribution of U in immune organs; blood, bone marrow, spleen, and thymus, as well as femur bones, kidneys, and liver, following a 60-d drinking water exposure to uranyl acetate (UA) in male and female C57BL/6J mice. Following the 60-d exposure, there was low overall tissue retention of U (<0.01 ) at both the 5 and the 50 ppm (mg/L) oral concentrations. In both male and female mice, there was limited U accumulation in immune organs. U only accumulated at low concentrations in the blood and bone marrow of male mice (0.6 and 16.8 ng/g, respectively). Consistent with previous reports, the predominant sites of U accumulation were the femur bones (350.1 and 399.0 ng/g, respectively) and kidneys (134.0 and 361.3 ng/g, respectively) of male and female mice. Findings from this study provide critical insights into the distribution and retention of U in lymphoid tissues following chronic drinking water exposure to U. This information will serve as a foundation for immunotoxicological assessments of U, alone and in combination with other metals.
Publication(s) associated with this dataset:- Bolt AM, Medina S, Lauer FT, Xu H, Ali AS, Liu K, Burchiel SW. 2018. Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice. PLoS One 13(10):e0205211. doi:10.1371/journal.pone.0205211 PMID:30356336 PMCID:PMC6200214