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Your Environment. Your Health.

Program Publications: University of New Mexico: UNM Metals Exposure and Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program

Superfund Research Program

UNM Metals Exposure and Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program

Center Director: Johnnye L. Lewis
Grant Number: P42ES025589
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's Twitter page


  • Hoover JH, Lin Y, Beene D, Liu Z. Partnering with Indigenous Communities to Address the Environmental Health Legacy of Abandoned Mines in the Western United States. In: The Rocky Mountain West: A Compendium of Geographic Perspectives. American Association of Geographers, Washington D.C., DC.
  • McLemore V, Frey BA, Hayek EE, Hettiarachchi E, Brown R, Chavez O, Paul S, Das M. The Jackpile-Paguate Uranium Mine, Grants Uranium District: Changes in perspectives from production to superfund site. In: The Geology of the Mount Taylor Area Special Publication. New Mexico Geological Society, NM.



  • Avasarala S, Brearley AJ, Spilde MN, Peterson EJ, Jiang Y, Benavidez A, Cerrato JM. 2020. Crystal chemistry of carnotite in abandoned mine wastes. Minerals 10(10):883. doi:10.3390/min10100883
  • Begay J, Sanchez B, Wheeler A, Baldwin F, Lucas S, Herbert G, Suarez YO, Shuey C, Klaver Z, Harkema JR, Wagner JG, Morishita M, Bleske B, Zychowski KE, Campen M. 2020. Assessment of particulate matter toxicity and physicochemistry at the Claim 28 uranium mine site in Blue Gap, AZ. J Toxicol Environ Health A 1-18. doi:10.1080/15287394.2020.1830210 PMID:33050837
  • Bush NR, Wakschlag LS, LeWinn KZ, Hertz-Picciotto I, Nozadi S, Pieper S, Lewis JL, Biezonski D, Blair C, Deardorff J, Neiderhiser JM, Leve LD, Elliott AJ, Duarte CS, Lugo-Candelas C, O'Shea TM, Avalos LA, Page GP, Posner J. 2020. Family environment, neurodevelopmental risk, and the Environmental Influences on Child Health Outcomes (ECHO) initiative: looking back and moving forward. Front Psychiatry 11:547. doi:10.3389/fpsyt.2020.00547 PMID:32636769 PMCID:PMC7318113
  • Dashner-Titus EJ, Schilz JR, Simmons KA, Duncan TR, Alvarez SC, Hudson LG. 2020. Differential response of human T-lymphocytes to arsenic and uranium. Toxicol Lett 333:269-278. doi:10.1016/j.toxlet.2020.08.013 PMID:32866568 PMCID:PMC7590629
  • De La Rosa VY, Hoover JH, Du R, Yakes Jimenez E, MacKenzie D, Lewis JL. 2020. Diet quality among pregnant women in the Navajo Birth Cohort Study. Matern Child Nutr doi:10.1111/mcn.12961
  • De Pree TA. 2020. The politics of baselining in the Grants uranium mining district of northwestern New Mexico. J Environ Manage 268:110601. doi:10.1016/j.jenvman.2020.110601 PMID:32510424
  • Gonzalez-Estrella J, Meza I, Burns A, Ali AS, Lezama-Pacheco JS, Lichtner PC, Shaikh N, Fendorf S, Cerrato JM. 2020. Effect of Bicarbonate, Calcium, and pH on the Reactivity of As(V) and U(VI) Mixtures. Environ Sci Technol 54:3979-3987. doi:10.1021/acs.est.9b06063 PMID:32176846 PMCID:PMC7189768
  • Johns A, Qian J, Carolan M, Shaikh N, Peroutka A, Seeger A, Cerrato JM, Forbes T, Cwiertny DM. 2020. Functionalized electrospun polymer nanofibers for treatment of water contaminated with uranium. Environ Sci-Wat Res 6(3):622-634. doi:10.1039/C9EW00834A
  • Kim H, Xue X. 2020. Detection of total reactive oxygen species in adherent cells by 2',7' -Dichlorodihydrofluorescein Diacetate staining. J Vis Exp 5:doi:10.3791/60682 PMID:32658187
  • Lin Y, Hoover JH, Beene D, Erdei E, Liu Z. 2020. Environmental risk mapping of potential abandoned uranium mine contamination on the Navajo Nation, USA, using a GIS-based multi-criteria decision analysis approach. Environ Sci Pollut Res Int doi:10.1007/s11356-020-09257-3 PMID:32468361
  • Medina S, Lauer FT, Castillo EF, Bolt AM, Ali AS, Liu K, Burchiel SW. 2020. Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice. Toxicol Appl Pharmacol 403:doi:10.1016/j.taap.2020.115155 PMID:32710956
  • Rodriguez-Freire L, DeVore C, Hayek EE, Berti D, Ali AS, Lezama-Pacheco JS, Blake JM, Spilde MN, Brearley AJ, Artyushkova K, Cerrato JM. 2020. Emerging investigator series: entrapment of uranium-phosphorus nanocrystals inside root cells of Tamarix plants from a mine waste site. Environ Sci Process Impacts doi:10.1039/d0em00306a PMID:33325952 (ahead of print)
  • Sanchez B, Zhou X, Gardiner SA, Herbert G, Lucas S, Morishita M, Wagner JG, Lewandowski R, Harkema JR, Shuey CL, Campen M, Zychowski KE. 2020. Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation. Part Fibre Toxicol 17:29. doi:10.1186/s12989-020-00361-3 PMID:32611356 PMCID:PMC7329534
  • Schantz SL, Eskenazi B, Buckley JP, Braun JM, Sprowles JN, Bennett DH, Cordero JF, Frazier JA, Lewis JL, Hertz-Picciotto I, Lyall K, Nozadi S, Sagiv SK, Stroustrup A, Watkins DJ. 2020. A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: opportunities and challenges. Environ Res 188:109709. doi:10.1016/j.envres.2020.109709 PMID:32526495
  • Sharma P, Caldwell TS, Rivera MN, Gullapalli RR. 2020. Cadmium exposure activates Akt/ERK Signaling and pro-inflammatory COX-2 expression in human gallbladder epithelial cells via a ROS dependent mechanism. Toxicol In Vitro 67:12. doi:10.1016/j.tiv.2020.104912 PMID:32512147
  • Zheng W, Ma Z, Sun X, Huang Y, Lu B, Chen X, Xue X, Yang X, Wu X. 2020. Exposure time determines the protective effect of Trichinella spiralis on experimental colitis. Microb Pathog 147:doi:10.1016/j.micpath.2020.104263 PMID:32442663


  • Avasarala S, Torres C, Ali AS, Thomson BM, Spilde MN, Peterson EJ, Artyushkova K, Dobrica E, Lezama-Pacheco JS, Cerrato JM. 2019. Effect of bicarbonate and oxidizing conditions on U (IV) and U (VI) reactivity in mineralized deposits of New Mexico. Chemical Geology 524:345-355. doi:10.1016/j.chemgeo.2019.07.007 PMID:31406388 PMCID:PMC6690612
  • Blake JM, Avasarala S, Ali AS, Spilde MN, Lezama-Pacheco JS, Latta DE, Artyushkova K, Ilgen A, Shuey CL, Nez C, Cerrato JM. 2019. Reactivity of As and U co-occurring in mine wastes in northeastern Arizona. Chemical Geology 522:26-37. doi:10.1016/j.chemgeo.2019.05.024 PMID:31371834 PMCID:PMC6675030
  • Bolt AM, Medina S, Lauer FT, Liu K, Burchiel SW. 2019. Minimal uranium immunotoxicity following a 60-day drinking water exposure to uranyl acetate in male and female C57BL/6J mice. Toxicol Appl Pharmacol 372:33-39. doi:10.1016/j.taap.2019.04.003 PMID:30978399
  • DeVore C, Rodriguez-Freire L, Mehdi-Ali A, Ducheneaux C, Artyushkova K, Zhou Z, Latta DE, Lueth VW, Gonzales M, Lewis JL, Cerrato JM. 2019. Effect of bicarbonate and phosphate on arsenic release from mining-impacted sediments in the Cheyenne River watershed, South Dakota, USA. Environ Sci Process Impacts 21(3):456-468. doi:10.1039/c8em00461g PMID:30714588 PMCID:PMC6474758
  • Hayek EE, Brearley AJ, Howard T, Hudson P, Torres C, Spilde MN, Cabaniss S, Ali AS, Cerrato JM. 2019. Calcium in carbonate water facilitates the transport of U(VI) in brassica juncea roots and enables root-to-shoot translocation. ACS Earth Space Chem 3(10):2190-2196. doi:10.1021/acsearthspacechem.9b00171 PMID:31742240 PMCID:PMC6859903
  • Hoover JH, Erdei E, Nash J, Gonzales M. 2019. A review of metal exposure studies conducted in the rural Southwestern and Mountain West Region of the United States. Curr Epidemiol Rep 6(1):34-49. doi:10.1007/s40471-019-0182-3 PMID:30906686 PMCID:PMC6429957
  • Luo L, Hudson LG, Lewis JL, Lee J. 2019. Two-step approach for assessing the health effects of environmental chemical mixtures: application to simulated datasets and real data from the Navajo Birth Cohort Study. Environ Health 18(46):doi:10.1186/s12940-019-0482-6 PMID:31072361 PMCID:PMC6507239
  • Miller C. 2019. Marginal probabilities and point estimation for conditionally specified logistic regression. Commun Stat Simul Comput doi:10.1080/03610918.2019.1643478
  • Nozadi S, Li L, Clifford J, Du R, Murphy K, Chen L, Anderson Q, Atene L, Barton L, Begay D, Begay D, Begay F, Begay M, Begay N, Begay P, Bennally D, Brown B, Cajero M, Chavez C, Chee B, Clawson B, Crank L, Erdei E, Francisco M, Harold V, Hoover JH, Kear L, Laselute C, Lee J, Lasiloo L, Mitchell P, Muskett O, Nez T, Phillips C, Ramone S, Reese D, Rondon A, Roman C, Rogers J, Swindal C, Sam D, Samuel M, Sanders A, Shuey C, Smith B, Tapaha M, Thompson R, Tsinnijinnie D, Tsosie M, Tsosie R, Tsosie S, Villavicecio J, Welch M, Watson J, Yazzie B, Seanez P, Burnette C, MacKenzie D, Lewis JL. 2019. Use of Ages and Stages Questionnaires (ASQ) in a Navajo population: comparison with the US normative dataset. Child Care Health Dev 45:5:709-718. doi:10.1111/cch.12704 PMID:31276599 PMCID:PMC6894904
  • O'Donald ER, Miller C, O'Leary R, Ong J, Pacheco B, Foos K, Enright K, O'Leary M, Henderson PN, Lewis JL, Erdei E, Henderson JA. 2019. Active smoking, secondhand smoke exposure and serum cotinine levels among Cheyenne River Sioux communities in context of a tribal public health policy. Tob Control doi:10.1136/tobaccocontrol-2019-055056 PMID:31462578
  • Velasco CA, Artyushkova K, Ali AS, Osburn CL, Gonzalez-Estrella J, Lezama Pacheco J, Cabaniss S, Cerrato JM. 2019. Organic functional group chemistry in mineralized deposits containing U(IV) and U(VI) from the Jackpile Mine in New Mexico. Environ Sci Technol 53(10):5758-5767. doi:10.1021/acs.est.9b00407 PMID:30998849 PMCID:PMC6557721
  • Xue X, Falcon DM. 2019. The role of immune cells and cytokines in intestinal wound healing. Int J Mol Sci 20:doi:10.3390/ijms20236097 PMID:31816903 PMCID:PMC6929186


  • Bolt AM, Medina S, Lauer FT, Xu H, Ali AS, Liu K, Burchiel SW. 2018. Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice. PLoS One 13(10):e0205211. doi:10.1371/journal.pone.0205211 PMID:30356336 PMCID:PMC6200214
  • Dashner-Titus EJ, Hoover JH, Li L, Lee J, Du R, Liu K, Traber MG, Ho E, Lewis JL, Hudson LG. 2018. Metal exposure and oxidative stress markers in pregnant Navajo Birth Cohort Study participants. Free Radic Biol Med 124:484-492. doi:10.1016/j.freeradbiomed.2018.04.579 PMID:29723666 PMCID:PMC6381929
  • Gonzales M, Erdei E, Hoover JH, Nash J. 2018. A review of environmental epidemiology studies in southwestern and mountain west rural minority populations. Curr Epidemiol Rep 5(2):101-113. doi:10.1007/s40471-018-0146-z PMID:30906685 PMCID:PMC6426134
  • Gonzales M, King E, Bobelu J, Ghahate DM, Madrid T, Lesansee S, Shah V. 2018. Perspectives on biological monitoring in environmental health research: A focus group study in a Native American community. Int J Environ Res Public Health 15(6):E1129. doi:10.3390/ijerph15061129 PMID:29857506 PMCID:PMC6025825
  • Harmon M, Lewis JL, Miller C, Hoover JH, Ali AS, Shuey CL, Cajero M, Lucas S, Pacheco B, Erdei E, Ramone S, Nez T, Campen M, Gonzales M. 2018. Arsenic association with circulating oxidized low-density lipoprotein in a Native American community. J Toxicol Environ Health A 81:535-548. doi:10.1080/15287394.2018.1443860 PMID:29641933 PMCID:PMC6042213
  • Hayek EE, Torres C, Rodriguez-Freire L, Blake JM, De Vore CL, Brearley AJ, Spilde MN, Cabaniss S, Ali AS, Cerrato JM. 2018. Effect of calcium on the bioavailability of dissolved uranium(VI) in plant roots under circumneutral pH. Environ Sci Technol 52(22):13089-13098. doi:10.1021/acs.est.8b02724 PMID:30412391
  • Hoover JH, Coker E, Barney Y, Shuey CL, Lewis JL. 2018. Spatial clustering of metal and metalloid mixtures in unregulated water sources on the Navajo Nation - Arizona, New Mexico, and Utah, USA. Sci Total Environ 633:1667-1678. doi:10.1016/j.scitotenv.2018.02.288 PMID:29669690 PMCID:PMC6051417 (accepted for publication)
  • Zychowski KE, Kodali V, Harmon M, Tyler CR, Sanchez B, Suarez YO, Herbert G, Wheeler A, Avasarala S, Cerrato JM, Kunda NK, Muttil P, Shuey CL, Brearley AJ, Ali AS, Lin Y, Shoeb M, Erdely A, Campen M. 2018. Respirable Uranyl-Vanadate-Containing Particulate Matter Derived From a Legacy Uranium Mine Site Exhibits Potentiated Cardiopulmonary Toxicity. Toxicol Sci 164:101-114. doi:10.1093/toxsci/kfy064 PMID:29660078 PMCID:PMC6016706


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