Superfund Research Program
UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research Program
Center Director: Jose Manuel Cerrato
Grant Number: P42ES025589
Funding Period: 2017-2027
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Title: Male mouse 60d water uranium exposure
Accession Number: doi:10.6073/pasta/cc93f3bc137b0ad638815dd7607bbf91
Link to Dataset: https://portal.edirepository.org/nis/mapbrowse?packageid=edi.495.1
Repository: EDI Data Portal (Environmental Data Initiative)
Data Type(s): Chemical & Chemical Biology, Exposure Data
Organism(s): Mus musculus
Summary: Male mice were exposed to uranium in the drinking water for 60 days. Doses of uranium (in the form of uranyl acetate) were 0, 5, and 50 ppb. We examined 1) immune function of splenocytes (mitogenesis) 2) lymphocyte population subsets in the bone marrow, spleen and thymus (flow cytometry) 3) erythroid cell differentiation in the bone marrow (flow cytometry) 4) uranium concentrations in kidney, femur bone, liver, blood spleen thymus and bone marrow (ICP-MS).