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University of North Carolina-Chapel Hill: Dataset Details, ID=GSE164542

Superfund Research Program

Research Experience and Training Coordination Core (RETCC)

Project Leader: Ilona Jaspers
Co-Investigators: Julia E. Rager, Meghan E. Rebuli
Grant Number: P42ES031007
Funding Period: 2020-2025
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Title: Wildfire Smoke-Induced Transcriptomic Changes in the Mouse Lung and Heart

Accession Number: GSE164542

Link to Dataset:

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by high throughput sequencing

Organism(s): Mus musculus

Summary: These analyses set out to evaluate transcriptomic responses in the mouse lung and heart in response to simulated wildland fire exposure conditions. These exposure conditions were based on smoke condensate consisting of particulate matter and semivolative organic compounds resulting from the burning of five biomass fuels; namely eucalyptus, pine, pine needles, peat, and red oak. These biomasses were evaluated under two burn conditions: flaming and smoldering.

Publication(s) associated with this dataset:
  • Carberry C, Koval L, Payton A, Hartwell HJ, Kim YH, Smith GJ, Reif DM, Jaspers I, Gilmour MI, Rager JE. 2022. Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke. Environ Int 167:doi:10.1016/j.envint.2022.107419 PMID:35863239 PMCID:PMC9389917
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