Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Person Details: Julia E. Rager

Superfund Research Program

Julia E. Rager

University of North Carolina-Chapel Hill
135 Dauer Drive
CB 7431
Chapel Hill, North Carolina 27599-7412
Phone: 713-594-1824
Email: jrager@unc.edu

Projects

Publications

2021

  • Chang Y, Rager JE, Tilton SC. 2021. Linking coregulated gene modules with polycyclic aromatic hydrocarbon-related cancer risk in the 3D human bronchial epithelium. Chem Res Toxicol 34(6):1445-1455. doi:10.1021/acs.chemrestox.0c00333 PMID:34048650
  • Manuck TA, Lai Y, Ru H, Glover AV, Rager JE, Fry RC, Lu K. 2021. Metabolites from mid-trimester plasma of pregnant patients at high-risk for preterm birth. Am J Obstet Gynecol doi:10.1016/j.ajogmf.2021.100393 PMID:33991707 (ahead of print)
  • Ring C, Sipes N, Hsieh J, Carberry C, Koval L, Klaren WD, Harris M, Auerbach SS, Rager JE. 2021. Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high-throughput toxicokinetics. Comput Toxicol 18:doi:10.1016/j.comtox.2021.100166 PMID:34013136 PMCID:PMC8130852

2020

  • Eaves LA, Nguyen HT, Rager JE, Sexton K, Howard T, Smeester L, Freedman AN, Aagaard KM, Shope C, Lefer B, Flynn JH, Erickson MH, Fry RC, Vizuete W. 2020. Identifying the Transcriptional Response of Cancer and Inflammation-Related Genes in Lung Cells in Relation to Ambient Air Chemical Mixtures. Environ Sci Technol 1380713816.
  • Eaves LA, Nguyen HT, Rager JE, Sexton K, Howard T, Smeester L, Freedman AN, Aagaard KM, Shope C, Lefer B, Flynn JH, Erickson MH, Fry RC, Vizuete W. 2020. Identifying the transcriptional response of cancer and inflammation-related genes in lung cells in relation to ambient air chemical mixtures in Houston, Texas. Environ Sci Technol 54:13807-13816. doi:10.1021/acs.est.0c02250 PMID:33064461 PMCID:PMC7757424
  • Eaves LA, Phookphan P, Rager JE, Bangma J, Santos H, Smeester L, O'Shea TM, Fry RC. 2020. A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta. Epigenomics 12:doi:10.2217/epi-2020-0062 PMID:32901510
  • Gomez JL, Chen A, Diaz M, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry RC, Rager JE, Cohn L, Alexis N, Chupp GL. 2020. A network of sputum microRNAs is associated with neutrophilic airway inflammation in asthma. Am J Respir Crit Care Med 1:51-64. doi:10.1164/rccm.201912-2360OC PMID:32255668 PMCID:PMC7328332
  • Payton A, Clark J, Eaves LA, Santos H, Smeester L, Bangma J, O'Shea TM, Fry RC, Rager JE. 2020. Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling. Reprod Toxicol 96:221-230. doi:10.1016/j.reprotox.2020.07.007 PMID:32721520 PMCID:PMC7855285
  • Rager JE, Bangma J, Carberry C, Chao A, Grossman J, Lu K, Manuck TA, Sobus JR, Szilagyi JT, Fry RC. 2020. Review of the environmental prenatal exposome and its relationship to maternal and fetal health. Reprod Toxicol 98:1-12. doi:10.1016/j.reprotox.2020.02.004 PMID:32061676 PMCID:PMC7442624
  • Zavala J, Freedman AN, Szilagyi JT, Jaspers I, Wambaugh J, Higuchi M, Rager JE. 2020. New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing. Int J Environ Res Public Health 6:2124. doi:10.3390/ijerph17062124 PMID:32210027 PMCID:PMC7143849

2019

2017

  • Rager JE, Auerbach SS, Chappell G, Martin EM, Thompson CM, Fry RC. 2017. Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort. Chem Res Toxicol 30(10):1911-1920. doi:10.1021/acs.chemrestox.7b00221

2015

  • Martin EA, Gonzalez-Horta C, Rager JE, Bailey KA, Sanchez-Ramirez B, Ballinas-Casarrubias L, Ishida MC, Gutierrez-Torres DS, Ceron RH, Morales DV, Baeza Terrazas FA, Saunders RJ, Drobna Z, Mendez MA, Buse JB, Loomis D, Jia W, Garcia-Vargas GG, Del Razo LM, Styblo M, Fry RC. 2015. Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico. Toxicol Sci 144(2):338-346. doi:10.1093/toxsci/kfu318 PMID:25577196 PMCID:PMC4372663
  • Rager JE, Tilley SK, Tulenko SE, Smeester L, Ray PD, Yosim A, Currier JM, Ishida MC, del Carmen Gonzalez-Horta M, Sanchez-Ramirez B, Ballinas-Casarrubias L, Gutierrez-Torres DS, Drobna Z, Del Razo LM, Garcia-Vargas GG, Kim WY, Zhou Y, Wright FA, Styblo M, Fry RC. 2015. Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol 28(6):1144-1155. doi:10.1021/tx500393y PMID:26039340 PMCID:PMC4748849
  • Rojas D, Rager JE, Smeester L, Bailey KA, Drobna Z, Rubio-Andrade M, Styblo M, Garcia-Vargas GG, Fry RC. 2015. Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci 143(1):97-106. doi:10.1093/toxsci/kfu210 PMID:25304211 PMCID:PMC4274382

2014

  • Bailey KA, Laine JE, Rager JE, Sebastian E, Olshan A, Smeester L, Drobna Z, Styblo M, Rubio-Andrade M, Garcia-Vargas GG, Fry RC. 2014. Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci 139(2):328-337. doi:10.1093/toxsci/kfu053 PMID:24675094 PMCID:PMC4031624
  • Rager JE, Moeller BC, Miller SK, Kracko D, Doyle-Eisele M, Swenberg JA, Fry RC. 2014. Formaldehyde-associated changes in microRNAs: tissue and temporal specificity in the rat nose, white blood cells, and bone marrow. Toxicol Sci 138(1):36-46. doi:10.1093/toxsci/kft267 PMID:24304932 PMCID:PMC3930361
  • Rager JE, Yosim A, Fry RC. 2014. Prenatal exposure to arsenic and cadmium impacts infectious disease-related genes within the glucocorticoid receptor signal transduction pathway. Int J Mol Sci 15(12):22374-22391. doi:10.3390/ijms151222374 PMID:25479081 PMCID:PMC4284714

2013

  • Ahir B, Sanders AP, Rager JE, Fry RC. 2013. Systems biology and birth defects prevention: Blockade of the glucocorticoid receptor prevents arsenic-induced birth defects. Environ Health Perspect 121(3):332-338. doi:10.1289/ehp.1205659 PMID:23458687 PMCID:PMC3616967
  • Rager JE, Moeller BC, Doyle-Eisele M, Kracko D, Swenberg JA, Fry RC. 2013. Formaldehyde and epigenetic alterations: microRNA changes in the nasal epithelium of nonhuman primates. Environ Health Perspect 121(3):339-344. doi:10.1289/ehp.1205582 PMID:23322811 PMCID:PMC3621188
  • Sanders AP, Smeester L, Rojas D, DeBussycher T, Wu MC, Wright FA, Zhou Y, Laine JE, Rager JE, Swamy GK, Ashley-Koch A, Miranda ML, Fry RC. 2013. Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs. Epigenetics 9(2):29-38. doi:10.4161/epi.26798 PMID:24169490 PMCID:PMC3962531
  • Swenberg JA, Moeller BC, Lu K, Rager JE, Fry RC, Starr TB. 2013. Formaldehyde carcinogenicity research: 30 years and counting for mode of action, epidemiology, and cancer risk assessment. Toxicol Pathol 41(2):181-189. doi:10.1177/0192623312466459 PMID:23160431 PMCID:PMC3893912

2012

Back
to Top