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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Luoping Zhang

Superfund Research Program

Luoping Zhang

University of California-Berkeley
School of Public Health
2121 Berkeley Way West, Room 5302
University of California - Berkeley
Berkeley, California 94720-7360
Phone: 510-643-5189
Fax: 510-642-0427
Email: luoping@berkeley.edu

Projects

Publications

2022

  • Germolec DR, Lebrec H, Anderson SE, Burleson GR, Cardenas A, Corsini E, Elmore S, Kaplan BL, Lawrence BP, Lehmann GM, Maier CC, McHale CM, Myers LP, Pallardy M, Rooney AA, Zeise L, Zhang L, Smith MT. 2022. Consensus on the key characteristics of immunotoxic agents as a basis for hazard identification. Environ Health Perspect 130(10):105001. doi:10.1289/EHP10800 PMID:36201310 PMCID:PMC9536493
  • Hosgood H, Rahman ML, Blansky D, Hu W, Davitt M, Wen C, Huang Y, Tang X, Li L, Smith MT, Zhang L, Vermeulen R, Rothman N, Bassig BA, Lan Q. 2022. Targeted proteomic scan identifies alteration of serum proteins among workers occupationally exposed to low levels of trichloroethylene. Environ Mol Mutagen 63(8-9):423-428. doi:10.1002/em.22518 PMID:36346153
  • Phillips RV, Wei L, Cardenas A, Hubbard AE, McHale CM, Vermeulen R, Wei H, Smith MT, Zhang L, Lan Q, Rothman N. 2022. Epigenome-wide association studies of occupational exposure to benzene and formaldehyde. Epigenetics 1-19. doi:10.1080/15592294.2022.2115604 PMID:36017556
  • Zhang L, Louie A, Rigutto G, Guo H, Zhao Y, Ahn S, Dahlberg S, Sholinbeck M, Smith MT. 2022. A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure. Environ Res 220:115188. doi:10.1016/j.envres.2022.115188 PMID:36592815

2021

  • Rana I, Dahlberg S, Steinmaus CM, Zhang L. 2021. Benzene exposure and non-Hodgkin lymphoma: A systematic review and meta-analysis of human studies. Lancet Planet Health 5(9):e633-e643. doi:10.1016/S2542-5196(21)00149-2 PMID:34450064
  • Rana I, Rieswijk L, Steinmaus CM, Zhang L. 2021. Formaldehyde and brain disorders: A meta-analysis and bioinformatics approach. Neurotox Res 39(3):doi:10.1007/s12640-020-00320-y PMID:33400181 (ahead of print)
  • Rider CV, McHale CM, Webster TF, Lowe L, Goodson III WH, La Merrill MA, Rice G, Zeise L, Zhang L, Smith MT. 2021. Using the key characteristics of carcinogens to develop research on chemical mixtures and cancer. Environ Health Perspect 129(3):35003. doi:10.1289/EHP8525 PMID:33784186 PMCID:PMC8009606
  • Rothman N, Vermeulen R, Zhang L, Hu W, Yin S, Rappaport SM, Smith MT, Jones DP, Rahman M, Lan Q, Walker DI. 2021. Metabolome-wide association study of occupational exposure to benzene. Carcinogenesis 42(11):doi:10.1093/carcin/bgab089 PMID:34606590 (ahead of print)
  • van der Laan L, Cardenas A, Vermeulen R, Fadadu RP, Hubbard AE, Phillips RV, Zhang L, Breeze C, Hu W, Wen C, Huang Y, Tang X, Smith MT, Rothman N, Lan Q. 2021. Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde. Environ Int 158:106871. doi:10.1016/j.envint.2021.106871 PMID:34560324
  • Zhao Y, Magana L, Cui H, Huang J, McHale CM, Yang X, Looney MR, Li R, Zhang L. 2021. Formaldehyde-induced hematopoietic stem and progenitor cell toxicity in mouse lung and nose. Arch Toxicol 95(2):693-701. doi:10.1007/s00204-020-02932-x PMID:33084937 PMCID:PMC7878325
  • Zhao Y, Wei L, Tagmount A, Loguinov AV, Sobh A, Hubbard AE, McHale CM, Chang C, Vulpe CD, Zhang L. 2021. Applying genome-wide CRISPR to identify known and novel genes and pathways that modulate formaldehyde toxicity. Chemosphere 269:128701. doi:10.1016/j.chemosphere.2020.128701 PMID:33189395 PMCID:PMC7904579

2020

  • Guo H, Ahn S, Zhang L. 2020. Benzene-associated immunosuppression and chronic inflammation in humans: a systematic review. Occup Environ Med doi:10.1136/oemed-2020-106517 PMID:32938756
  • Schildroth S, Osborne G, Smith A, Yip C, Collins C, Smith MT, Sandy MS, Zhang L. 2020. Occupational exposure to antimony trioxide: A risk assessment. Occup Environ Med doi:10.1136/oemed-2020-106980 PMID:33243757 PMCID:PMC8149478 (ahead of print)
  • Smith MT, Guyton KZ, Kleinstreuer N, Borrell A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson III WH, Houck K, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden MR. 2020. The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them. Cancer Epidemiol Biomarkers Prev 29(10):doi:10.1158/1055-9965.EPI-19-1346 PMID:32152214 PMCID:PMC7483401
  • Zhang L, Guo H. 2020. Biomarkers of COVID-19 and technologies to combat SARS-CoV-2. Adv Biomark Sci Technol 2:1-23. doi:10.1016/j.abst.2020.08.001 PMID:33511330 PMCID:PMC7435336

2019

  • Lee KM, Bassig BA, Zhang L, Vermeulen R, Hu W, Wong JJ, Wen C, Huang Y, Purdue MP, Ji B, Li L, Tang X, Rothman N, Smith MT, Lan Q. 2019. Association between occupational exposure to trichloroethylene and serum levels of microRNAs: a cross-sectional molecular epidemiology study in China. Int Arch Occup Environ Health 92(8):1077-1085. doi:10.1007/s00420-019-01448-x PMID:31161417 PMCID:PMC6953905
  • Lee KM, Zhang L, Vermeulen R, Hu W, Bassig BA, Wong JJ, Qiu C, Purdue MP, Wen C, Walker DI, Jones DP, Li L, Huang Y, Rothman N, Smith MT, Lan Q. 2019. Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards. Occup Environ Med 76(6):376-381. doi:10.1136/oemed-2018-105583 PMID:30971425 PMCID:PMC6953904
  • Luderer U, Eskenazi B, Hauser R, Korach KS, McHale CM, Moran-Messen FM, Rieswijk L, Solomon G, Udagawa O, Zhang L, Zlatnik M, Zeise L, Smith MT. 2019. Proposed key characteristics of female reproductive toxicants as an approach for organizing and evaluating mechanistic data in hazard assessment. Environ Health Perspect 127:75001. doi:10.1289/ehp4971 PMID:31322437 PMCID:PMC6791466
  • Sobh A, Loguinov AV, Stornetta A, Balbo S, Tagmount A, Zhang L, Vulpe CD. 2019. Genome-wide CRISPR screening identifies the tumor suppressor candidate OVCA2 as a determinant of tolerance to acetaldehyde. Toxicol Sci 169:235-245. doi:10.1093/toxsci/kfz037 PMID:31059574 PMCID:PMC6484886
  • Sobh A, Loguinov AV, Yazici GN, Zeidan RS, Tagmount A, Hejazi NS, Hubbard AE, Zhang L, Vulpe CD. 2019. Functional profiling identifies determinants of arsenic trioxide cellular toxicity. Toxicol Sci 169:108-121. doi:10.1093/toxsci/kfz024 PMID:30815697 PMCID:PMC6484884
  • Zhang L, Rana L, Shaffer RM, Taioli E, Sheppard L. 2019. Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: a meta-analysis and supporting evidence. Mutat Res Rev Mutat Res doi:10.1016/j.mrrev.2019.02.001 (in press)

2018

  • Daniels SI, Chambers JC, Sanchez SS, La Merrill MA, Hubbard AE, Macherone A, McMullin M, Zhang L, Elliott P, Smith MT, Kooner JS. 2018. Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes. J Endocr Soc 2(8):832-841. doi:10.1210/js.2017-00480 PMID:30019022 PMCID:PMC6041775
  • Grigoryan H, Edmands WM, Lan Q, Carlsson H, Vermeulen R, Zhang L, Yin S, Li G, Smith MT, Rothman N, Rappaport SM. 2018. Adductomic signatures of benzene exposure provide insights into cancer induction. Carcinogenesis 39:661-668. doi:10.1093/carcin/bgy042 PMID:29538615 PMCID:PMC5932554
  • Guo J, Zhao Y, Jiang X, Li R, Xie H, Ge L, Xie B, Yang X, Zhang L. 2018. Exposure to formaldehyde perturbs the mouse gut microbiome. Genes (Basel) 9:18. doi:10.3390/genes9040192 PMID:29614050 PMCID:PMC5924534
  • McHale CM, Osborne G, Morello-Frosch R, Salmon AG, Sandy MS, Solomon G, Zhang L, Smith MT, Zeise L. 2018. Assessing health risks from multiple environmental stressors: moving from G x E to I x E. Mutat Res Rev Mutat Res 775:11-20. doi:10.1016/j.mrrev.2017.11.003 PMID:29555026 PMCID:PMC5863617
  • Rothman N, Zhang L, Smith MT, Vermeulen R, Lan Q. 2018. Formaldehyde, hematotoxicity, and chromosomal changes-response. Cancer Epidemiol Biomarkers Prev 27:120-121. doi:10.1158/1055-9965.epi-17-0804 PMID:29311167
  • Schiffman C, McHale CM, Hubbard AE, Zhang L, Thomas R, Vermeulen R, Li G, Shen M, Rappaport SM, Yin S, Lan Q, Smith MT, Rothman N. 2018. Identification of gene expression predictors of occupational benzene exposure. PLoS One 13(10):e0205427. doi:10.1371/journal.pone.0205427 PMID:30300410
  • Tachachartvanich P, Sangsuwan R, Ruiz HS, Sanchez SS, Durkin KA, Zhang L, Smith MT. 2018. Assessment of the endocrine-disrupting effects of trichloroethylene and its metabolites using in vitro and in silico approaches. Environ Sci Technol 52(3):1542-1550. doi:10.1021/acs.est.7b04832 PMID:29294279 PMCID:PMC6290898

2017

  • de la Rosa R, Steinmaus CM, Akers NK, Conde L, Ferreccio Readi C, Kalman DA, Zhang KR, Skibola CF, Smith AH, Zhang L, Smith MT. 2017. Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a Chilean population. Environ Mol Mutagen 58(6):411-422. doi:10.1002/em.22104 PMID:28640505 PMCID:PMC5515250
  • De La Rosa VY, Asfaha J, Fasullo M, Loguinov AV, Li P, Moore LE, Rothman N, Nakamura J, Swenberg JA, Scelo G, Zhang L, Smith MT, Vulpe CD. 2017. Editor's highlight: High-throughput functional genomics identifies modulators of TCE metabolite genotoxicity and candidate susceptibility genes. Toxicol Sci 160:111-120. doi:10.1093/toxsci/kfx159 PMID:28973557 PMCID:PMC5837773
  • Rothman N, Lan Q, Smith MT, Vermeulen R, Zhang L. 2017. Response to letter to the editor of Carcinogenesis by Pira et al., 2017. Carcinogenesis 38:1253-1255. doi:10.1093/carcin/bgx111 PMID:29040449

2016

  • Bassig BA, Zhang L, Vermeulen R, Tang X, Li G, Hu W, Guo W, Purdue MP, Yin S, Rappaport SM, Shen M, Ji Z, Qiu C, Ge Y, Hosgood H, Reiss B, Wu B, Xie Y, Li L, Yue F, Freeman LB, Blair AE, Hayes RB, Huang H, Smith MT, Rothman N, Lan Q. 2016. Comparison of hematological alterations and markers of B-cell activation in workers exposed to benzene, formaldehyde and trichloroethylene. Carcinogenesis 37(7):692-700. doi:10.1093/carcin/bgw053 PMID:27207665 PMCID:PMC4936387
  • Shen H, McHale CM, Haider SI, Jung C, Zhang S, Smith MT, Zhang L. 2016. Identification of genes that modulate susceptibility to formaldehyde and imatinib by functional genomic screening in human haploid KBM7 cells. Toxicol Sci 151(1):10-22. doi:10.1093/toxsci/kfw032 PMID:27008852 PMCID:PMC4914802
  • Walker D, Uppal K, Zhang L, Vermeulen R, Smith MT, Hu W, Purdue MP, Tang X, Reiss B, Kim S, Li L, Huang H, Pennell KD, Jones DP, Rothman N, Lan Q. 2016. High-resolution metabolomics of occupational exposure to trichloroethylene. Int J Epidemiol 45(5):1517-1527. doi:10.1093/ije/dyw218 PMID:27707868 PMCID:PMC5100622

2015

  • Bailey H, Infante-Rivard C, Metayer C, Clavel J, Lightfoot TJ, Kaatsch P, Roman E, Magnani C, Spector LG, Petridou E, Milne E, Dockerty JD, Miligi L, Armstrong BK, Rudant J, Fritschi L, Simpson J, Zhang L, Rondelli R, Baka M, Orsi L, Moschovi M, Kang AY, Schuz J. 2015. Home pesticide exposures and risk of childhood leukemia: findings from the childhood leukemia international consortium. Int J Cancer 137(11):2644-2663. doi:10.1002/ijc.29631 PMID:26061779 PMCID:PMC4572913
  • Goodson III WH, Lowe L, Carpenter DO, Gilbertson M, Ali AM, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen A, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Bagole CJ, Dong C, Mondello C, Hsu C, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon E, Laconi E, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten F, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams GP, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Hamid HA, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu H, Park HH, Koturbash I, Miousse IR, Scovassi A, Klaunig JE, Vondracek J, Raju J, Roman J, Wise Sr. JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohine-Solal KA, Moorwood KA, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin L, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Manjili MH, Lleonart ME, Xia M, Gonzalez Guzman MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, Van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Darbre PD, Leung PS, Nangia-Makker P, Cheng Q(, Robey R, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Hamid RA, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Erikkson S, Forte S, Casey SC, Luanpitpong S, Lee T, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engstrom W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. 2015. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis 36Suppl1:S254-S296. doi:10.1093/carcin/bgv039 PMID:26106142 PMCID:PMC4480130
  • Ji Z, McHale CM, Bersonda J, Tung J, Smith MT, Zhang L. 2015. Induction of centrosome amplification by formaldehyde, but not hydroquinone, in human lymphoblastoid TK6 cells. Environ Mol Mutagen 56(6):535-544. doi:10.1002/em.21947 PMID:25821186
  • Lan Q, Smith MT, Tang X, Guo W, Vermeulen R, Ji Z, Hu W, Hubbard AE, Shen M, McHale CM, Qiu C, Liu S, Reiss B, Beane-Freeman L, Blair AE, Ge Y, Xiong J, Li L, Rappaport SM, Huang H, Rothman N, Zhang L. 2015. Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde. Carcinogenesis 36(1):160-167. doi:10.1093/carcin/bgu229 PMID:25391402 PMCID:PMC4291049
  • Shen H, McHale CM, Smith MT, Zhang L. 2015. Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9. Mutat Res Rev Mutat Res 764:31-42. doi:10.1016/j.mrrev.2015.01.002 PMID:26041264 PMCID:PMC4456615
  • Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C. 2015. Global characteristics of childhood acute promyelocytic leukemia. Blood Rev 29(2):101-125. doi:10.1016/j.blre.2014.09.013 PMID:25445717 PMCID:PMC4379131

2014

  • Bassig BA, Zhang L, Cawthon RM, Smith MT, Yin S, Li G, Hu W, Shen M, Rappaport SM, Barone-Adesi F, Rothman N, Vermeulen R, Lan Q. 2014. Alterations in leukocyte telomere length in workers occupationally exposed to benzene. Environ Mol Mutagen 55(8):673-678. doi:10.1002/em.21880 PMID:24945723 PMCID:PMC4360990
  • Daniels SI, Sille FC, Goldbaum A, Yee B, Key EF, Zhang L, Smith MT, Thomas R. 2014. Improving power to detect changes in blood miRNA expression by accounting for sources of variability in experimental designs. Cancer Epidemiol Biomarkers Prev 23(12):2658-2666. doi:10.1158/1055-9965.EPI-14-0623 PMID:25472674 PMCID:PMC4256675
  • McHale CM, Smith MT, Zhang L. 2014. Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: From yeast to human. Ann N Y Acad Sci 1310:74-83. doi:10.1111/nyas.12382 PMID:24571325 PMCID:PMC3978411
  • North M, Shuga J, Fromowitz M, Loguinov AV, Shannon K, Zhang L, Smith MT, Vulpe CD. 2014. Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke. BMC Cancer 14:6. doi:10.1186/1471-2407-14-6 PMID:24386979 PMCID:PMC3898384
  • Thomas R, Hubbard AE, McHale CM, Zhang L, Rappaport SM, Lan Q, Rothman N, Vermeulen R, Guyton KZ, Jinot J, Sonawane B, Smith MT. 2014. Characterization of changes in gene expression and biochemical pathways at low levels of benzene exposure. PLoS One 9(5):e91828. doi:10.1371/journal.pone.0091828 PMID:24786086 PMCID:PMC4006721

2013

  • Hosgood H, Zhang L, Tang X, Vermeulen R, Hao Z, Shen M, Qiu C, Ge Y, Hua M, Ji Z, Li S, Xiong J, Reiss B, Liu S, Xin KX, Azuma M, Xie Y, Freeman LB, Ruan X, Guo W, Galvan N, Blair AE, Li L, Huang H, Smith MT, Rothman N, Lan Q. 2013. Occupational exposure to formaldehyde and alterations in lymphocyte subsets. Am J Ind Med 56:252-257. doi:10.1002/ajim.22088 PMID:22767408 PMCID:PMC3493854
  • McHale CM, Zhang L, Lan Q, Thomas R, Hubbard AE, Vermeulen R, Li G, Rappaport SM, Yin S, Smith MT, Rothman N. 2013. Toxicogenomic and systems biology approaches in the understanding of toxicity and leukemogenesis induced by benzene. The Toxicologist, Society of Toxicology Meeting, March 2013.
  • McHale CM, Zhang L, Thomas R, Smith MT. 2013. Analysis of the transcriptome in molecular epidemiology studies. Environ Mol Mutagen 54(7):500-517. doi:10.1002/em.21798 PMID:23907930 PMCID:PMC5142298
  • Metayer C, Zhang L, Wiemels JL, Bartley K, Schiffman J, Ma X, Aldrich MC, Chang JS, Selvin S, Fu CH, Ducore J, Smith MT, Buffler PA. 2013. Tobacco smoke exposure and the risk of childhood acute lymphoblastic and Myeloid Leukemias by cytogenetic subtype. Cancer Epidemiol Biomarkers Prev 22(9):1600. doi:10.1158/1055-9965.epi-13-0350 PMID:23853208 PMCID:PMC3769478
  • Ren X, Ji Z, McHale CM, Yuh J, Bersonda J, Tang M, Smith MT, Zhang L. 2013. The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines. Arch Toxicol 87(1):189-196. doi:10.1007/s00204-012-0911-6 PMID:22872141 PMCID:PMC4312773
  • Shuga J, Zeng Y, Novak R, Lan Q, Tang X, Rothman N, Vermeulen R, Li L, Hubbard AE, Zhang L, Mathies RA, Smith MT. 2013. Single molecule quantitation and sequencing of rare translocations using microfluidic nested digital PCR. Nucleic Acids Res 41(16):e159. doi:10.1093/nar/gkt613 PMID:23873959 PMCID:PMC3763562
  • Thomas R, McHale CM, Lan Q, Hubbard AE, Zhang L, Vermeulen R, Li G, Rappaport SM, Yin S, Rothman N, Smith MT. 2013. Global gene expression response of a population exposed to benzene: A pilot study exploring the use of RNA-sequencing technology. Environ Mol Mutagen 54(7):566-573. doi:10.1002/em.21801 PMID:23907980 PMCID:PMC4353497
  • Zhang L, Bassig BA, Mora JL, Vermeulen R, Ge Y, Curry JD, Hu W, Shen M, Qiu C, Ji Z, Reiss B, McHale CM, Liu S, Guo W, Purdue MP, Yue F, Li L, Smith MT, Huang H, Tang X, Rothman N, Lan Q. 2013. Alterations in serum immunoglobulin levels in workers occupationally exposure to trichloroethylene. Carcinogenesis 34(4):799-802. doi:10.1093/carcin/bgs403 PMID:23276795 PMCID:PMC3616671

2012

  • Fromowitz M, Shuga J, Wlassowsky AY, Ji Z, North M, Vulpe CD, Smith MT, Zhang L. 2012. Bone marrow genotoxicity of 2,5-dimethylfuran, a green biofuel candidate. Environ Mol Mutagen 53:488-491. doi:10.1002/em.21707 PMID:22730236
  • Godderis L, Thomas R, Hubbard AE, Tabish AM, Hoet P, Zhang L, Smith MT, Veulemans H, McHale CM. 2012. Effect of chemical mutagens and carcinogens on gene expression profiles in human TK6 cells. PLoS One 7(6):e39205. doi:10.1371/journal.pone.0039205 PMID:22723965 PMCID:PMC3377624
  • Hosgood H, Zhang L, Tang X, Vermeulen R, Qiu C, Shen M, Smith MT, Ge Y, Ji Z, Xiong J, He J, Reiss B, Liu S, Xie Y, Guo W, Galvan N, Li L, Hao Z, Rothman N, Huang H, Lan Q. 2012. Decreased numbers of CD4+ naive and effector memory T cells, and CD8+, are associated with trichloroethylene exposure. Front Oncol 1:53. doi:10.3389/fonc.2011.00053 PMID:22649769 PMCID:PMC3355872
  • Ji Z, Weldon RH, Marchetti F, Chen H, Li G, Xing C, Kurtovich E, Young SS, Schmid TE, Waidyanatha S, Rappaport SM, Zhang L, Eskenazi B. 2012. Comparison of aneuploidies of chromosomes 21, X, and Y in the blood lymphocytes and sperm of workers exposed to benzene. Environ Mol Mutagen 53(3):218-26. doi:10.1002/em.21683 PMID:22351378
  • Ji Z, Zhang L. 2012. Chromosomics: Detection of numerical and structural alterations in all 24 human chromosomes simulaneously using a novel OctoChrome FISH assay. J Vis Exp 6(60):e3619. doi:10.3791/3619 PMID:22331009 PMCID:PMC3369631
  • Marchetti F, Eskenazi B, Weldon RH, Li G, Zhang L, Rappaport SM, Schmid TE, Xing C, Kurtovich E, Wyrobek AJ. 2012. Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men. Environ Health Perspect 120(2):229-234. doi:10.1289/ehp.1103921 PMID:22086566 PMCID:PMC3279447
  • McHale CM, Zhang L, Smith MT. 2012. Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis doi:10.1093/carcin/bgr297 PMID:22166497 PMCID:PMC3271273
  • O'Connor SF, Lan J, North M, Loguinov AV, Zhang L, Smith MT, Gu AZ, Vulpe CD. 2012. Genome-wide functional and stress response profiling reveals toxic mechanism and genes required for tolerence to benzo[a]pyrene in S. cerevisiae. Front Genet 3:316. doi:10.3389/fgene.2012.00316 PMID:23403841 PMCID:PMC3567348
  • Phuong J, Kim S, Thomas R, Zhang L. 2012. Predicted toxicity of the biofuel candidate 2,5-dimethylfuran in environmental and biological systems. Environ Mol Mutagen 53(6):478-487. doi:10.1002/em.21702 PMID:22730190
  • Thomas R, Phuong J, McHale CM, Zhang L. 2012. Using bioinformatic approaches to identify pathways targeted by human leukemogens. Int J Environ Res Public Health 9(7):2479-2503. doi:10.3390/ijerph9072479 PMID:22851955 PMCID:PMC3407916
  • Vermeulen R, Zhang L, Spierenburg A, Bonventre JV, Reiss B, Shen M, Smith MT, Qiu C, Ge Y, Ji Z, Xiong J, He J, Hao Z, Liu S, Xie Y, Yue F, Guo W, Purdue MP, Freeman LB, Sabbisetti V, Li L, Huang H, Rothman N, Lan Q, Tang X. 2012. Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene. Carcinogenesis 33(8):1538-1541. doi:10.1093/carcin/bgs191 PMID:22665366 PMCID:PMC3499056
  • Zhang L, Lan Q, Ji Z, Li G, Shen M, Guo W, Hubbard AE, McHale CM, Rappaport SM, Hayes RB, Linet MS, Yin S, Smith MT, Rothman N, Vermeulen R. 2012. Leukemia-specific chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers. Leukemia 26(12):2494-2498. doi:10.1038/leu.2012.143 PMID:22643707 PMCID:PMC3472034

2011

  • Chu F, Ren X, Chasse A, Hickman T, Zhang L, Yuh J, Smith MT, Burlingame AL. 2011. Quantitative mass spectrometry reveals the epigenome as a target of arsenic. Chem Biol Interact 192(1-2):113-117. doi:10.1016/j.cbi.2010.11.003 PMID:21075096 PMCID:PMC4360996
  • McHale CM, Zhang L, Hubbard AE, Smith MT. 2011. Transcriptomic studies in human populations. Chapter 9 in: Applications of toxicogenomics in safety evaluation and risk assessment. John Wiley & Sons, Hoboken, NJ. pp.177-206.
  • McHale CM, Zhang L, Lan Q, Vermeulen R, Li G, Hubbard AE, Porter KE, Thomas R, Portier CJ, Shen M, Rappaport SM, Yin S, Rothman N, Smith MT. 2011. Global gene expression profiling of a population exposed to a range of benzene levels. Environ Health Perspect 119:628-634. doi:10.1289/ehp.1002546 PMID:21147609 PMCID:PMC3094412
  • North M, Tandon VJ, Thomas R, Loguinov AV, Gerlovina I, Hubbard AE, Zhang L, Smith MT, Vulpe CD. 2011. Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast. PLoS One 6(8):e24205. doi:10.1371/journal.pone.0024205 PMID:21912624 PMCID:PMC3166172
  • Ren X, Aleshin M, Jo WJ, Kalman DA, Vulpe CD, Smith MT, Zhang L. 2011. Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity. Environ Health Perspect 119:771-777. doi:10.1289/ehp.1002733 PMID:21193388 PMCID:PMC3114810
  • Ren X, Lim S, Ji Z, Yuh J, Peng V, Smith MT, Zhang L. 2011. Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. PLoS One 6:e14546. doi:10.1371/journal.pone.0014546 PMID:21267443 PMCID:PMC3022623
  • Ren X, McHale CM, Skibola CF, Smith AH, Smith MT, Zhang L. 2011. An emerging role for epigenetic dysregulation in arsenic toxicity 
and carcinogenesis. Environ Health Perspect 119(1):11-19. doi:10.1289/ehp.1002114 PMID:20682481 PMCID:PMC3018488
  • Shen M, Zhang L, Lee KM, Vermeulen R, Hosgood H, Yin S, Rothman N, Chanock SJ, Smith MT, Lan Q, Li G. 2011. Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity. Exp Mol Med 43:374-378. doi:10.3858/emm.2011.43.6.041 PMID:21540635 PMCID:PMC3128916
  • Smith MT, Zhang L, McHale CM, Skibola CF, Rappaport SM. 2011. Benzene, the exposome and future investigations of leukemia etiology. Chem Biol Interact 192(1-2):155-159. doi:10.1016/j.cbi.2011.02.010 PMID:21333640 PMCID:PMC3461963
  • Zhang L, Lan Q, Guo W, Hubbard AE, Li G, Rappaport SM, McHale CM, Shen M, Vermeulen R, Yin S, Rothman N, Smith MT, Ji Z. 2011. Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene. Carcinogenesis 32:605-612. doi:10.1093/carcin/bgq286 PMID:21216845 PMCID:PMC3066415

2010

  • Ji Z, Zhang L, Peng V, Ren X, McHale CM, Smith MT. 2010. A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide. Leukemia 24(5):986-991. doi:10.1038/leu.2010.43 PMID:20339439 PMCID:PMC4353491
  • Lan Q, Zhang L, Tang X, Shen M, Smith MT, Qiu C, Ge Y, Ji Z, Xiong J, He J, Reiss B, Hao Z, Liu S, Xie Y, Guo W, Purdue MP, Galvan N, Xin KX, Hu W, Freeman LB, Blair AE, Li L, Rothman N, Vermeulen R, Huang H. 2010. Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers. Carcinogenesis 31(9):1592-1596. doi:10.1093/carcin/bgq121 PMID:20530238 PMCID:PMC2930801
  • Vlaanderan J, Moore LE, Smith MT, Lan Q, Zhang L, Skibola CF, Rothman N, Vermeulen R. 2010. Application of OMICS technologies in occupational and environmental health research; current status and projections. Occup Environ Med 67(2):136-143. doi:10.1136/oem.2008.042788 PMID:19933307 PMCID:PMC2910417
  • Xing C, Marchetti F, Li G, Weldon RH, Kurtovich E, Young SS, Schmid TE, Zhang L, Rappaport SM, Waidyanatha S, Wyrobek AJ, Eskenazi B. 2010. Benzene exposure near the US permissible limit is associated with sperm aneuploidy. Environ Health Perspect 118:833-839. doi:10.1289/ehp.0901531 PMID:20418200 PMCID:PMC2898861
  • Zhang L, McHale CM, Rothman N, Li G, Ji Z, Vermeulen R, Hubbard AE, Ren X, Shen M, Rappaport SM, North M, Skibola CF, Yin S, Vulpe CD, Chanock SJ, Smith MT, Lan Q. 2010. Systems biology of human benzene exposure. Chem Biol Interact 184(1-2):86-93. doi:10.1016/j.cbi.2009.12.011 PMID:20026094 PMCID:PMC2846187
  • Zhang L, Tang X, Rothman N, Vermeulen R, Ji Z, Shen M, Qiu C, Guo W, Liu S, Reiss B, Freeman LB, Ge Y, Hubbard AE, Hua M, Blair AE, Galvan N, Ruan X, Alter BP, Xin KX, Li S, Moore LE, Kim S, Xie Y, Hayes RB, Azuma M, Hauptmann M, Xiong J, Stewart P, Li L, Rappaport SM, Huang H, Fraumeni JF, Smith MT, Lan Q. 2010. Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells. Cancer Epidemiol Biomarkers Prev 19(1):80-88. doi:10.1158/1055-9965.EPI-09-0762 PMID:20056626 PMCID:PMC2974570

2009

  • Guyton KZ, Kyle AD, Aubrecht J, Cogliano VJ, Eastmond DA, Jackson M, Keshava N, Sandy MS, Sonawane B, Zhang L, Waters M, Smith MT. 2009. Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches. Mutat Res Rev Mutat Res 681(2-3):230-240. doi:10.1016/j.mrrev.2008.10.001 PMID:19010444
  • Ji Z, Zhang L, Guo W, McHale CM, Smith MT. 2009. The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells. Mutagenesis 24(4):367-372. doi:10.1093/mutage/gep018 PMID:19491217 PMCID:PMC2701990
  • Jo WJ, Loguinov AV, Wintz H, Chang M, Smith AH, Vulpe CD, Kalman DA, Zhang L, Smith MT. 2009. Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast. Toxicol Sci 111(2):424-436. doi:10.1093/toxsci/kfp162 PMID:19635755 PMCID:PMC2742584
  • Jo WJ, Ren X, Chu F, Aleshin M, Wintz H, Burlingame AL, Smith MT, Vulpe CD, Zhang L. 2009. Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Toxicol Appl Pharmacol 241(3):294-302. doi:10.1016/j.taap.2009.08.027 PMID:19732783 PMCID:PMC2784148
  • Lan Q, Zhang L, Shen M, Jo WJ, Vermeulen R, Li G, Vulpe CD, Lim S, Ren X, Rappaport SM, Berndt SI, Yeager M, Yuenger J, Hayes RB, Linet MS, Yin S, Chanock SJ, Smith MT, Rothman N. 2009. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis 30(1):50-58. doi:10.1093/carcin/bgn249 PMID:18978339 PMCID:PMC2639030
  • McHale CM, Zhang L, Lan Q, Li G, Hubbard AE, Forrest MS, Vermeulen R, Chen J, Shen M, Rappaport SM, Yin S, Smith MT, Rothman N. 2009. Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms. Genomics 93(4):343-349. doi:10.1016/j.ygeno.2008.12.006 PMID:19162166 PMCID:PMC2693268
  • Rappaport SM, Kim S, Lan Q, Vermeulen R, Waidyanatha S, Zhang L, Li G, Yin S, Hayes RB, Rothman N, Smith MT. 2009. Evidence that humans metabolize benzene via two pathways. Environ Health Perspect 117:946-952. doi:10.1289/ehp.0800510 PMID:19590688 PMCID:PMC2702411
  • Ren X, Lim S, Smith MT, Zhang L. 2009. Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone. Toxicol Sci 107(2):367-375. doi:10.1093/toxsci/kfn254 PMID:19064679 PMCID:PMC2639759
  • Scelo G, Metayer C, Zhang L, Wiemels JL, Aldrich MC, Selvin S, Month S, Smith MT, Buffler PA. 2009. Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environ Health Perspect 117(1):133-139. PMID:19165400
  • Zhang L, Steinmaus CM, Eastmond DA, Xin XK, Smith MT. 2009. Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms. Mutat Res Rev Mutat Res 681(2-3):150-168. doi:10.1016/j.mrrev.2008.07.002 PMID:18674636

2008

  • Galvan N, Lim S, Zmugg S, Smith MT, Zhang L. 2008. Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone. Mutat Res 649(1-2):54-61. doi:10.1016/j.mrgentox.2007.07.011 PMID:17875398 PMCID:PMC3461953
  • Hegedus CM, Skibola CF, Warner M, Skibola DR, Zhang L, Steinmaus CM, Smith AH, Smith MT, Moore LE, Alexander D, Lim S, Dangleben NL, Clark M, Pfeiffer RM. 2008. Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenic. Toxicol Sci 106(1):74-82. doi:10.1093/toxsci/kfn104 PMID:18511430 PMCID:PMC2563143
  • Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit CJ, Loh ML, Buffler PA, Yeh R. 2008. Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally. Cancer Res 68(23):9935-9944. doi:10.1158/0008-5472.CAN-08-2139 PMID:19047175 PMCID:PMC2597307

2007

  • Escobar PA, Smith MT, Vasishta A, Hubbard AE, Zhang L. 2007. Leukaemia-specific chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH). Mutagenesis 22(5):321-327. doi:10.1093/mutage/gem020 PMID:17575318
  • Kim S, Lan Q, Waidyanatha S, Chanock SJ, Johnson BA, Vermeulen R, Smith MT, Zhang L, Li G, Shen M, Yin S, Rothman N, Rappaport SM. 2007. Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations. Pharmacogenet Genomics 17(10):789-801. PMID:17885617
  • Lin Y, Vermeulen R, Tsai CH, Waidyanatha S, Lan Q, Rothman N, Smith MT, Zhang L, Shen M, Li G, Yin S, Kim S, Rappaport SM. 2007. Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers. Environ Health Perspect 115(1):28-34. PMID:17366815
  • McHale CM, Zhang L, Hubbard AE, Zhao X, Baccarelli A, Pesatori AC, Smith MT, Landi MT. 2007. Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects. Toxicology 229:101-113. PMID:17101203
  • Zhang L, Rothman N, Li G, Guo W, Yang W, Hubbard AE, Hayes RB, Yin S, Lu W, Smith MT. 2007. Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers. Environ Mol Mutagen 48(6):467-74. PMID:17584886

2006

  • Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. 2006. Cytogenetics of hispanic and white children with acute lymphoblastic leukemia in california. Cancer Epidemiol Biomarkers Prev 15(3):578-581. PMID:16537719
  • Kim S, Vermeulen R, Waidyanatha S, Johnson BA, Lan Q, Rothman N, Smith MT, Zhang L, Li G, Shen M, Yin S, Rappaport SM. 2006. Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. Carcinogenesis 27(4):772-81. PMID:16339183
  • Kim S, Vermeulen R, Waidyanatha S, Johnson BA, Lan Q, Smith MT, Zhang L, Li G, Shen M, Yin S, Rothman N, Rappaport SM. 2006. Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev 15(11):2246-52. PMID:17119053
  • Shen M, Lan Q, Zhang L, Chanock SJ, Li G, Vermeulen R, Rappaport SM, Guo W, Hayes RB, Linet MS, Yin S, Yeager M, Welch R, Forrest MS, Rothman N, Smith MT. 2006. Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity. Carcinogenesis 27(10):2083-2089. doi:10.1093/carcin/bgl061 PMID:16728435
  • Vermeulen R, Lan Q, Li G, Rappaport SM, Kim S, van Wendel de Joode B, Shen M, Bohong X, Smith MT, Zhang L, Yin S, Rothman G. 2006. Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches. J Environ Monit 8(11):1143-8. PMID:17075621

2005

  • Lan Q, Zhang L, Hakim F, Shen M, Memon S, Li G, Vermeulen R, Smith MT, Rappaport SM, Hayes RB, Linet MS, Yin S, Rothman N, Rabkin CS. 2005. Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzene. Chem Biol Interact 153-154:111-115. PMID:15935806
  • Lan Q, Zhang L, Shen M, Smith MT, Li G, Vermeulen R, Rappaport SM, Forrest MS, Hayes RB, Linet MS, Dosemeci M, Alter BP, Weinberg RS, Yin S, Yeager M, Welch R, Waidyanatha S, Kim S, Chanock SJ, Rothman N. 2005. Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. Cancer Res 65(20):9574-9581. doi:10.1158/0008-5472.CAN-05-1419 PMID:16230423
  • Rappaport SM, Waidyanatha S, Yeowell-O'Connell K, Rothman N, Smith MT, Zhang L, Qu Q, Shore R, Li G, Yin S. 2005. Protein adducts as biomarkers of human benzene metabolism. Chem Biol Interact 153-154:103-109. PMID:15935805
  • Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. 2005. Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol 206(2):237-245. PMID:15967214
  • Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. 2005. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia 19(3):415-419. PMID:15674422

2004

  • Lan Q, Zhang L, Li G, Vermeulen R, Weinberg RS, Dosemeci M, Rappaport SM, Shen M, Alter BP, Wu Y, Kopp W, Waidyanatha S, Rabkin CS, Guo W, Chanock SJ, Hayes RB, Linet MS, Kim S, Yin S, Rothman N, Smith MT. 2004. Hematotoxicity in workers exposed to low levels of benzene. Science 306(5702):1774-1776. doi:10.1126/science.1102443 PMID:15576619 PMCID:PMC1256034
  • Vermeulen R, Li G, Lan Q, Dosemeci M, Rappaport SM, Bohong X, Smith MT, Zhang L, Hayes RB, Linet MS, Mu R, Wang L, Xu J, Yin S, Rothman N. 2004. Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China. Ann Occup Hyg 48(2):105-116. PMID:14990432
  • Zhang L, Hayes RB, Guo W, McHale CM, Yin S, Wiencke JK, O'Neill JP, Rothman N, Li G, Smith MT. 2004. Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes. Mutat Res 558(1-2):63-74. PMID:15036120
  • Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. 2004. Hypermethylation of the 5 ' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res 64(6):2000-2006. PMID:15026336

2003

  • Escobar PA, Zhang L, Smith MT. 2003. Chemically induced damage to specific regions of DNA detected by cometfish. Environ Mol Mutagen 41(3):174.
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Feusner J, Matthay KK, Dahl GV, Smith MT. 2003. Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16). Blood 101(11):4640-4641. PMID:12756163
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W, Loh ML, Smith MT. 2003. Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California. Genes, Chromosomes and Cancer 37(1):36-43. PMID:12661004
  • Smith MT, Wiencke JK, Wiemels JL, Zhang L, Ma X, McHale CM, Buffler PA. 2003. Molecular epidemiology of childhood leukemia. Environ Mol Mutagen 41(3):206.
  • Wiencke JK, Zheng S, Smith MT, Zhang L, Ma X, Wiemels JL, Marsit CJ, Kelsey KT, Buffler PA. 2003. Methylation of transcribed PTEN pseudogene in pediatric leukemia is associated with subtypes of common ALL containing t(12;21) translocation. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.
  • Zhang L, Zheng S, Ma X, Wiemels JL, Buffler PA, Smith MT, Wiencke JK. 2003. Molecular cytogenetic characterization of childhood acute lymphoblastic leukemia and its relation to FHIT gene methylation. Environ Mol Mutagen 41(3):215.
  • Zheng S, Ma X, Wiemels JL, Zhang L, Gunn L, Smith MT, Buffler PA, Wiencke JK. 2003. Hypermethylation of the 5'CpG island of the FHIT gene is associated with hyperdiploid and translocation negative subtypes of pediatric leukemia. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.

2002

  • Gunn L, Forrest MS, Zhang L, Holland NT, Smith MT. 2002. Biomarkers of early effect in the study of cancer risk. Chapter 22 in: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press Company, Boca Raton, FL. pp.319.
  • Guo W, Zhang L, Yang W, Smith MT. 2002. Chromosomal aneuploidy detected at different stages of cervical cancer using interphase cytongenetics. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3698.
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Smith MT. 2002. Prenatal origin of TEL-AML positive acute lymphoblastic leukemia in children born in California. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4566.
  • Rappaport SM, Yeowell-O'Connell K, Smith MT, Dosemeci M, Hayes RB, Zhang L, Li G, Yin S, Rothman N. 2002. Non-linear production of benzene oxide-albumin adducts with human exposure to benzene. J Chromatogr A 778:367-374. PMID:12376141
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4567.
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood 99(10):3801-3805. PMID:11986239
  • Yang W, Zhang L, Hubbard AE, Wang Y, Smith MT. 2002. Non-random chromosome damage may be important in chemical carinogenesis. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3451.
  • Zhang L, Eastmond DA, Smith MT. 2002. The nature of chromosomal aberrations detected in humans exposed to benzene. Crit Rev Toxicol 32(1):1-42. PMID:11846214
  • Zhang L, Guo W, Rothman N, Lan Q, Yang W, Lo C, Li G, Turakulov RI, Yin S, Smith MT. 2002. Application of OctoChrome FISH device to detect leukemia and lymphoma specific chromosome aberrations in molecular epidemiology and toxicology. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3810.
  • Zhang L, Yang W, Hubbard AE, Wang Y, Smith MT. 2002. Is chromosomal aneuploidy induced by benzene metabolites random or selective?. Environ Mol Mutagen 39(Suppl33):230.

2001

  • Yeowell-O'Connell K, Rothman N, Waidyanatha S, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 2001. Protein adducts of 1,4-benzoquinone and benzene oxide among smokers and nonsmokers exposed to benzene in China. Cancer Epidemiol Biomarkers Prev 10:831-838. PMID:11489749

2000

  • Hayes RB, Zhang L, Yin S, Swenberg JA, Xi L, Wiencke JK, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Zhang D, Wiemels JL, Dosemeci M, Li G, Smith MT. 2000. Genotoxic markers among butadiene-polymer workers in China. Carcinogenesis 21(1):55-62. PMID:10607734
  • Smith MT, Zhang L, Jeng M, Wang Y, Guo W, Duramad P, Hubbard AE, Hofstadler G, Holland NT. 2000. Hydroquinone, a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells. Carcinogenesis 21(8):1485-1490. PMID:10910948
  • Zhang L, Rothman N, Wang Y, Guo W, Hayes RB, Li G, Yin S, Smith MT. 2000. Spectrum of chromosomal changes detected by fluorescence in situ hybridization in workers exposed to benzene. Proc Am Assoc Cancer Res 41:Abstract2777.

1999

  • Holland NT, Zhang L, Smith MT. 1999. Cytogenetic biomarkers and air pollution. In: Proceedings of the 7th International Inhalation Symposium, 1999. Hanover, Germany.
  • Rothman N, Campleman S, Hayes RB, Hoener B, Yin S, Dosemeci M, Meyer KB, Li G, Zhang L, Smith MT. 1999. High CYP2E1 activity is a risk factor for benzene poisoning. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.282.
  • Rothman N, Traver RD, Smith MT, Hayes RB, Li G, Campleman S, Dosemeci M, Zhang L, Linet MS, Wacholder S, Yin S, Ross D. 1999. Lack of NAD(P)H:quinone oxidoreductase activity (NQ01) is associated with increased risk of benzene hematotoxicity. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.258.
  • Smith MT, Zhang L, Wang Y, Li G, Hayes RB, Kolachana P, Dosemeci M, Holland NT, Xi L, Yin S, Rothman N. 1999. Translocations between chromosome 8 and 21 in workers exposed to benzene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Xi L, Zhang L, Wang Y, Smith MT. 1999. Induction of chromosome-specific aneusomy and micronuclei in human lymphocytes by metabolites of 1, 3-butadiene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Yeowell-O'Connell K, Rothman N, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1999. Hemoglobin adducts of benzene oxide in workers exposed to high levels of benzene in China. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.251.
  • Yeowell-O'Connell K, Rothman N, Waidyanatha S, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1999. Albumin adducts of benzene oxide, 1, 2- and 1, 4 benzoquinones in benzene exposed workers. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.477.
  • Zhang L, Rothman N, Li G, Wang Y, Hayes RB, Guo W, Lu W, Zhang D, Yin S, Smith MT. 1999. Molecular cytogenetics of humans exposed to benzene and 1,3-butadiene. In: Proceedings of the 1999 HEI (The Health Effects Institute ) Annual Conference. San Diego, CA.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT. 1999. Benzene exposure is associated with increased aneusomy and long arm deletion of chromosomes 5 and 7 in Chinese workers. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.628.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Li G, Smith MT. 1999. Aneuploidy of chromosomes 7, 8 and 9 detected by fluorescence in situ hybridization in workers exposed to benzene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.112.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Titenko-Holland N, Dosemeci M, Wang Y, Kolachana P, Lu W, Xi L, Li G, Smith MT. 1999. Benzene increases aneuploidy in the lymphocytes of exposed workers: A comparison of data obtained by fluorescence in situ hybridization in interphase and metaphase cells. Environ Mol Mutagen 34:260-268. PMID:10618174
  • Zhang L, Wang Y, Shang N, Smith MT. 1999. Differential chromosome sensitivity to aneuploidy induced by benzene and its metabolites. Proc Am Assoc Cancer Res Abstract3365.

1998

  • Smith MT, Zhang L. 1998. Biomarkers of leukemia risk: benzene as a model. Environ Health Perspect 106(4):937-946. PMID:9703476
  • Smith MT, Zhang L, Wang Y, Hayes RB, Li G, Wiemels JL, Dosemeci M, Holland NT, Xi L, Kolachana P, Yin S, Rothman N. 1998. Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene. Cancer Res 58(10):2176-2181. PMID:9605763
  • Titenko-Holland N, Shao J, Zhang L, Xi L, Ngo H, Shang N, Smith MT. 1998. Studies on the genotoxicity of molybdenum salts in human cells in vitro and in mice in vivo. Environ Mol Mutagen 32(3):251-259. PMID:9814440
  • Titenko-Holland N, Zhang L, Smith MT. 1998. Biomarkers of genetic damage in humans. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, Honolulu, Hawaii, 22-24 April, 1998. Honolulu, HI. pp.141-143.
  • Yeowell-O'Connell K, Rothman N, Smith MT, Hayes RB, Li G, Waidyanatha S, Dosemeci M, Zhang L, Yin S, Titenko-Holland N, Rappaport SM. 1998. Hemoglobin and albumin adducts of benzene oxide among workers exposed to high levels of benzene. Carcinogenesis 19(9):1565-1571. PMID:9771926
  • Yeowell-O'Connell K, Rothman N, Waidyanatha S, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1998. Albumin adducts of benzene oxide, 1, 2-and 1, 4 benzoquinones in benzene exposed workers. Chapter 39in: Proceedings of the Eighty Nineth Annual Meeting of the (AACR) American Association for Cancer Research, March 28th-April 1st, 1998. New Oreleans, LA. pp.477.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT. 1998. Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene. Carcinogenesis 19(11):1955-1961. PMID:9855009
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Titenko-Holland N, Yin S, Shang N, Smith MT. 1998. The loss and long arm deletions of chromosomes 5 and 7 in human lymphocytes treated with benzene metabolites and in workers exposed to benzene. Environ Mol Mutagen 31(29):72.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Titenko-Holland N, Dosemeci M, Kolachana P, Xi L, Li G, Smith MT. 1998. A comparison of interphase and metaphase FISH analysis of aneusomy in benzene-exposed workers. Environ Mol Mutagen 31(29):72.
  • Zhang L, Wang L, Shang N, Smith MT. 1998. Benzene metabolites induce the loss and long arm deletion of chromosomes 5 and 7 in human lymphocytes. Leuk Res 22(2):105-113. PMID:9593466

1997

  • Holland NT, Shao J, Zhang L, Ngo H, Shang N, Smith MT. 1997. Molybdenum salts are genotoxic. In: Proceedings of Environmental Mutagen Society Meeting, 1997. Minneapolis, MN.
  • Rothman N, Smith MT, Hayes RB, Traver RD, Hoener B, Campleman S, Li G, Dosemeci M, Linet MS, Zhang L, Xi L, Wacholder S, Lu W, Meyer KB, Titenko-Holland N, Stewart JT, Yin S, Ross D. 1997. Benzene poisoning, a risk factor for hematologic malignancy, is associated with the NQ01 609C->T mutation and rapid fractional excretion of chlorzoxazone. Cancer Res 57(14):2839-2842. PMID:9230185
  • Smith MT, Rothman N, Yin S, Zhang L, Dosemeci M, Wang Y, Li G, Hayes RB. 1997. Benzene exposure and risk of MDS/AML. Leuk Res Supp.1:S3.
  • Xi L, Zhang L, Wang Y, Smith MT. 1997. Induction of chromosome-specific aneuploidy and micronuclei in human lymphocytes by metabolites of 1,3-butadiene. Carcinogenesis 18(9):1687-1693. PMID:9328162
  • Xi L, Zhang L, Wang Y, Smith MT. 1997. Induction of chromosome-specific aneusomy and micronuclei in human lymphocytes by metabolites of 1, 3-butadiene. Chapter 38in: Proceedings of the Eighty Eightieth Annual Meeting of the (AACR) American Association for Cancer Research, 1997.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT. 1997. Benzene exposure is associated with increased aneusomy and long arm deletion of chromosomes 5 and 7 in Chinese workers. Chapter 38in: Proceedings of the Eighty Eightieth Annual Meeting of the (AACR) American Association for Cancer Research, 1997. pp.628.

1996

  • Rothman N, Li G, Dosemeci M, Bechtold WE, Marti GE, Wang Y, Linet MS, Xi L, Lu W, Smith MT, Titenko-Holland N, Zhang L, Blot W, Yin S, Hayes RB. 1996. Hematotoxicity among Chinese workers heavily exposed to benzene. Am J Ind Med 29:236-246. PMID:8833776
  • Rothman N, Smith MT, Hayes RB, Li G, Irons RD, Dosemeci M, Haas R, Stillman WS, Linet MS, Xi L, Bechtold WE, Wiemels JL, Campleman S, Zhang L, Quintana PJ, Titenko-Holland N, Wang Y, Lu W, Kolachana P, Meyer KB, Yin S. 1996. An epidemiologic study of early biologic effects of benzene in Chinese workers. Environ Health Perspect 104(6):1365-1370. PMID:9118921
  • Rothman N, Traver RD, Smith MT, Hayes RB, Li G, Campleman S, Dosemeci M, Zhang L, Linet MS, Wacholder S, Yin S, Ross D. 1996. Lack of NAD(P)H:quinone oxidoreductase activity (NQ01) is associated with increased risk of benzene hematotoxicity. Chapter 37in: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996. pp.258.
  • Shao J, Zhang L, Semenza JC, Beach B, Smith MT. 1996. Tetrasomy 8 detected by interphase cytogenetics in a child with acute lymphocytic leukemia. Cancer Genet Cytogenet 92:135-140. PMID:8976370
  • Smith MT, Rothman N, Zhang L, Wang Y, Hayes RB, Yin S. 1996. Molecular cytogenetics of humans exposed to benzene. Environ Health Perspect 30(1,part2):911.
  • Smith MT, Zhang L, Wang Y, Li G, Hayes RB, Kolachana P, Dosemeci M, Titenko-Holland N, Xi L, Yin S, Rothman N. 1996. Translocations between chromosome 8 and 21 in workers exposed to benzene. In: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996.
  • Yeowell-O'Connell K, Rothman N, Wang Y, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1996. Hemoglobin adducts of benzene oxide in workers exposed to high levels of benzene in China. Chapter 37in: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996. pp.251.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Bechtold WE, Venkatesh P, Yin S, Wang Y, Dosemeci M, Li G, Lu W, Smith MT. 1996. Interphase cytogenetics of workers exposed to benzene. Environ Health Perspect 104Suppl6:1325-1329. PMID:9118914 PMCID:PMC1469718

1995

  • Rothman N, Campleman S, Hayes RB, Hoener B, Yin S, Dosemeci M, Meyer KB, Li G, Zhang L, Smith MT. 1995. High CYP2E1 activity is a risk factor for benzene poisoning. Chapter 36in: Proceedings of the Eighty Sixth Annual Meeting of the (AACR) American Association of Cancer Research, March, 1995. Ontario, Canada. pp.282.
  • Rothman N, Haas R, Hayes RB, Li G, Wiemels JL, Campleman S, Quintana PJ, Xi L, Dosemeci M, Titenko-Holland N, Meyer KB, Lu W, Zhang L, Bechtold WE, Wang Y, Kolachana P, Yin S, Blot W, Smith MT. 1995. Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans. Proc Natl Acad Sci U S A 92(9):4069-4073. PMID:7732033
  • Xi L, Zhang L, Smith MT. 1995. Butadiene metabolites induce micronuclei and aneuploidy in human lymphocytes. In: Proceedings of the International symposium on evaluation of butadiene & isoprene health risks. Blaine, WA.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Li G, Smith MT. 1995. Aneuploidy of chromosomes 7, 8 and 9 detected by fluorescence in situ hybridization in workers exposed to benzene. Chapter 36in: Proceedings of the Eighty Sixth Annual Meeting of the (AACR) American Association of Cancer Research, March, 1995. Ontario, Canada. pp.112.
  • Zhang L, Shiverick KT. 1995. Regulation of gene expression and cell proliferation in human placental choriocarcinoma cells by 2,3,7,8-tetachlorodibenzo-p-dioxin. Environ Health Perspect 15:67.
  • Zhang L, Smith MT, Bandy B, Tamaki SJ, Davison AJ. 1995. Role of quinones, active oxygen species and metals in the genotoxicity of 1,2,4-benzenetriol, a metabolite of benzene. In: Free radicals in the Environment, and Toxicology. Richelieu Press, London, United Kingdom. pp.521-562.
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