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Your Environment. Your Health.

Person Details: Anatoly Zhitkovich

Superfund Research Program

Anatoly Zhitkovich

Brown University
Laboratories of Molecular Medicine
70 Ship St., Room 507
Providence, Rhode Island 02912
Phone: 401-863-2912
Fax: 401-863-9008


Research Briefs





  • Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt RH, Kane AB. 2011. Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci 124(1):138-148. doi:10.1093/toxsci/kfr206 PMID:21828359 PMCID:PMC3196652 (Completed with ARRA Funds)
  • Zhitkovich A. 2011. Chromium in drinking water: sources, metabolism, and cancer risks. Chem Res Toxicol 24(10):1617–1629. doi:10.1021/tx200251t PMID:21766833 PMCID:PMC3196244 (Completed with ARRA Funds)



  • Zecevic A, Menard H, Gurel V, Hagan E, DeCaro R, Zhitkovich A. 2009. WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts. Cell Cycle 8(17):2769-78. PMID:19652551



  • Liu X, Gurel V, Morris D, Murray DW, Zhitkovich A, Kane AB, Hurt RH. 2007. Bioavailability of nickel in single-wall carbon nanotubes. Advanced Materials 19:2790-96.
  • Reynolds M, Stoddard L, Bespalov I, Zhitkovich A. 2007. Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair. Nucleic Acids Res 35(2):465-476. doi:10.1093/nar/gkl1069 PMID:17169990 PMCID:PMC1802609
  • Reynolds M, Zhitkovich A. 2007. Cellular vitamin C increases chromate toxicity via a death program requiring mismatch repair but not p53. Carcinogenesis 28(7):1613-1620. PMID:17301063


  • Quievryn G, Messer J, Zhitkovich A. 2006. Lower mutagenicity but higher stability of Cr-DNA adducts formed during gradual chromate activation with ascorbate. Carcinogenesis 27(11):2316-2321. PMID:16714765


  • Sutherland JE, Zhitkovich A, Kluz T, Costa M. 2000. Rats retain chromium in tissues following chronic ingestion of drinking water containing hexavalent chromium. Biol Trace Elem Res 74(1):41-53. PMID:11049199
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