Superfund Research Program

Rory B. Conolly

U.S. Environmental Protection Agency (EPA)
National Center for Computational Toxicology, ORD
109 TW Alexander Drive
Mail Code B205-01
Research Triangle Park, North Carolina 27711
Phone: 919-541-3350
Email: Conolly.rory@epa.gov

Projects

• Michigan State University: Research Support A: Computational Modeling of Mammalian Biomolecular Responses (2006-2021)

Publications

2022

• Liu R, Zacharewski TR, Conolly RB, Zhang Q. 2022. A physiologically based pharmacokinetic (PBPK) modeling framework for mixtures of dioxin-like compounds. Toxics 10(11):700. doi:10.3390/toxics10110700 PMID:36422908 PMCID:PMC9698634

2021

• Gingrich J, Filipovic D, Conolly RB, Veiga-Lopez A. 2021. Pregnancy-specific physiologically-based toxicokinetic models for bisphenol A and bisphenol S. Environ Int 147:106301. doi:10.1016/j.envint.2020.106301 PMID:33360411 PMCID:PMC7856209

2019

• Zhang Q, Caudle W, Pi J, Bhattacharya S, Andersen ME, Kaminski NE, Conolly RB. 2019. Embracing systems toxicology at single-cell resolution. Curr Opin Toxicol 16:49-57. doi:10.1016/j.cotox.2019.04.003 PMID:31768481 PMCID:PMC6876623

2018

• Zhang Q, Li J, Middleton A, Bhattacharya S, Conolly RB. 2018. Bridging the data gap from in vitro toxicity testing to chemical safety assessment through computational modeling. Front Public Health 6:261. doi:10.3389/fpubh.2018.00261 PMID:30255008 PMCID:PMC6141783

2014

• Zhang Q, Bhattacharya S, Conolly RB, Clewell H, Andersen ME. 2014. Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses. Environ Health Perspect 122(12):1261-1270. doi:10.1289/ehp.1408244 PMID:25117432 PMCID:PMC4256703

2013

• Zhang Q, Kline DE, Bhattacharya S, Crawford RB, Conolly RB, Thomas RS, Andersen ME, Kaminski NE. 2013. All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 268(1):17-26. doi:10.1016/j.taap.2013.01.015 PMID:23357550 PMCID:PMC3594464

2010

• Bhattacharya S, Conolly RB, Kaminski NE, Thomas RS, Andersen ME, Zhang Q. 2010. A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 115(1):51-65. doi:10.1093/toxsci/kfq035 PMID:20123757 PMCID:PMC2855357
• Kline DE, Zhang Q, Bhattacharya S, Andersen ME, Conolly RB, Crawford RB, Kaminski NE. 2010. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Suppresses LPS-activated Binary Switching of B Cells to Plasma Cells.
• Zhang Q, Bhattacharya S, Andersen ME, Conolly RB. 2010. Computational systems biology and dose-response modeling in relation to new directions in toxicity testing. J Environ Sci Health B 13(2-4):253-76. doi:10.1080/10937404.2010.483943 PMID:20574901
• Zhang Q, Bhattacharya S, Kline DE, Crawford RB, Thomas RS, Kaminski NE, Andersen ME, Conolly RB. 2010. Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin. BMC Syst Biol 4:40. doi:10.1186/1752-0509-4-40 PMID:20359356 PMCID:PMC2859749

2006

• Zhang Q, Thomas RS, Kaminski NE, Conolly RB, Andersen ME. 2006. Computational modeling of TCDD disruption of B-cell terminal differentiation. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.

2004

• Slikker W, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, David RM, Doerrer NG, Dorman DC, Gaylor DW, Hattis D, Rogers JM, Setzer RW, Swenberg JA, Wallace K, Andersen ME. 2004. Dose-dependent transitions in mechanisms of toxicity. Toxicol Appl Pharmacol 201(3):203-225. PMID:15582645

2003

• Andersen ME, Ou YC, Yang RH, Conolly RB, Thomas RS, Gustafson DL, Long ME, Dobrev ID, Chubb LS, Xu Y, Lapidot SA. 2003. Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. Toxicol Sci 73(2):301-314. PMID:12700395

2001

• Ou YC, Conolly RB, Thomas RS, Xu Y, Andersen ME, Chubb LS, Pitot HC, Yang RH. 2001. A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay. Cancer Res 61(5):1879-1889. PMID:11280742

2000

• Thomas RS, Conolly RB, Gustafson DL, Long ME, Benjamin SA, Yang RH. 2000. A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator. Toxicol Appl Pharmacol 166(2):128-137. PMID:10896854