Superfund Research Program

Leona D. Samson

Massachusetts Institute of Technology
.77 Massachusetts Avenue
Cambridge, Massachusetts 02139-4307
Phone: 617-253-7813
Email: lsamson@mit.edu

Projects

• Massachusetts Institute of Technology: NDMA and DNA Alkylation Repair in the Liver: Impact of Gene-Environment Interactions on Cellular Responses, Mutations and Cancer (2017-2022)

Publications

2023

• Armijo AL, Thongararm P, Fedeles BI, Yau J, Kay JE, Corrigan JJ, Chancharoen M, Chawanthayatham S, Samson LD, Carrasco SE, Engelward BP, Fox JG, Croy RG, Essigmann JM. 2023. Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents. NAR Cancer 5(2):doi:10.1093/narcan/zcad015 PMID:36992846 PMCID:PMC1004153

2021

• Ge J, Ngo LP, Kaushal S, Tay IJ, Thadhani E, Kay J, Mazzucato P, Chow DN, Fessler JL, Weingeist DM, Sobol RW, Samson LD, Floyd SR, Engelward BP. 2021. CometChip enables parallel analysis of multiple DNA repair activities. DNA Repair (Amst) 106(11):doi:10.1016/j.dnarep.2021.103176 PMID:34365116 PMCID:PMC8439179
• Kay J, Corrigan JJ, Armijo AL, Nazari IS, Kohale I, Torous DK, Avlasevich SL, Croy RG, Wadduwage DN, Carrasco SE, Dertinger SD, White FM, Essigmann JM, Samson LD, Engelward BP. 2021. Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice. Cell Rep 34(11):108864. doi:10.1016/j.celrep.2021.108864 PMID:33730582

2020

• Ngo LP, Owiti NA, Swartz C, Winters J, Su Y, Ge J, Xiong A, Han J, Recio L, Samson LD, Engelward BP. 2020. Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates. Nucleic Acids Res 48(3):e13. doi:10.1093/nar/gkz1077 PMID:31822921 PMCID:PMC7026589

2019

• Kay J, Thadhani E, Samson LD, Engelward BP. 2019. Inflammation-induced DNA damage, mutations and cancer. DNA Repair (Amst) 83:doi:10.1016/j.dnarep.2019.102673 PMID:31387777 PMCID:PMC6801086
• Navasumrit P, Chaisatra K, Promvijit J, Parnlob V, Waraprasit S, Chompoobut C, Binh T, Hai D, Bao N, Hai N, Kim K, Samson LD, Graziano JH, Mahidol C, Ruchirawat K. 2019. Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study. Environ Health 18:51. doi:10.1186/s12940-019-0481-7 PMID:31174534 PMCID:PMC6555940
• Ngo LP, Chan TK, Ge J, Samson LD, Engelward BP. 2019. Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation. Cell Rep 26:1668-1678. doi:10.1016/j.celrep.2019.01.053 PMID:30726746 PMCID:PMC6431241

2007

• Beyer RP, Lasarev MR, Meira LB, Palmer VS, Ross PK, Bammler TK, Bradford BU, Cunningham ML, Higgins G, Hurban P, Kayton RJ, Kosyk O, Vliet PA, Wolfinger R, Woods CG, Freedman JH, Linney EA, Kaufmann WK, Kavanagh TJ, Rusyn I, Samson LD, Spencer PS, Suk WA, Zarbl HF. 2007. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 99(1):326-337. PMID:17562736

2005

• Bammler TK, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li Y, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'Malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin L, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin J, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl HF. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2(5):351-6. PMID:15846362

2004

• Ham AL, Engelward BP, Koc H, Sangaiah R, Meira LB, Samson LD, Swenberg JA. 2004. New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N-6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo. DNA Repair (Amst) 3(3):257-265. PMID:15177041
• Kisby GE, Lam-Lesselroth H, Olivas A, Samson LD, Gold B, Tanaka K, Turker MS. 2004. Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death. DNA Repair (Amst) 3(6):617-627. PMID:15135729

2002

• Sobol RW, Watson DE, Nakamura J, Yakes FM, Hou E, Horton JK, Wu J, Van Houten B, Swenberg JA, Tindall KR, Samson LD, Wilson SH. 2002. Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proc Natl Acad Sci U S A 99(14):6860-6865. PMID:11983862