Superfund Research Program

Carmen J. Marsit

Emory University
1518 Clifton Road NE
1518-002-2BB
Atlanta, Georgia 30322
Phone: 404-712-8912
Fax: 404-727-8744
Email: carmen.j.marsit@emory.edu

Projects

• Brown University: Environment, Genetics and Epigenetics in a R.I. Birth Cohort (2009-2014)

Publications

2023

• Bulka C, Everson TM, Burt AA, Marsit CJ, Karagas MR, Boyle KE, Niemiec S, Kechris K, Davidson EJ, Yang IV, Feinberg JI, Volk HE, Ladd-Acosta C, Breton CV, O'Shea TM, Fry RC. 2023. Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis. Epigenetics 18(1):2179726. doi:10.1080/15592294.2023.2179726 PMID:36840948 PMCID:PMC9980626
• Freedman AN, Clark J, Eaves LA, Roell K, Oran A, Koval L, Rager JE, Santos HP, Kuban K, Joseph RM, Frazier JA, Marsit CJ, Burt AA, O'Shea TM, Fry RC. 2023. A multi-omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm. Autism Res 16(5):918-934. doi:10.1002/aur.2915 PMID:36938998 PMCID:PMC10192070

2022

• Moroishi Y, Salas LA, Zhou J, Baker E, Hoen AG, Everson TM, Marsit CJ, Madan J, Gui J, Karagas MR. 2022. Umbilical cord blood immune cell profiles in relation to the infant gut microbiome. iScience 26(1):105833. doi:10.1016/j.isci.2022.105833 PMID:36632065 PMCID:PMC9826880

2020

• Hussey MR, Burt AA, Deyssenroth MA, Jackson BP, Hao K, Peng S, Chen J, Marsit CJ, Everson TM. 2020. Placental lncRNA expression associated with placental cadmium concentrations and birth weight. Environ Epigenet 6:doi:10.1093/eep/dvaa003
• Tian F, Everson TM, Lester B, Punshon T, Jackson BP, Hao K, Lesseur C, Chen J, Karagas MR, Marsit CJ. 2020. Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: An epigenome-wide study of two U.S. birth cohorts. Environ Int 137:doi:10.1016/j.envint.2020.105508 PMID:32007686 PMCID:PMC7722519

2019

• Andrew AS, Karagas MR, Schroeck FR, Marsit CJ, Schned AR, Pettus JR, Armstrong DA, Seigne JD. 2019. MicroRNA Dysregulation and Non-Muscle-Invasive Bladder Cancer Prognosis. Cancer Epidemiol Biomarkers Prev 28:728-788. doi:10.1158/1055-9965.EPI-18-0884 PMID:30700445 PMCID:PMC6473178

2018

• Reynolds LJ, Chavan NR, DeHoff LB, Preston J, Maddox HF, O'Brien JM, Armstrong DA, Marsit CJ, Pearson KJ. 2018. Smoking during pregnancy increases chemerin expression in neonatal tissue. Exp Physiol 104(1):93-99. doi:10.1113/EP087307 PMID:30565770 PMCID:PMC6312488

2014

• Koestler DC, Li J, Baron JA, Tsongalis GJ, Butterly LF, Goodrich M, Lesseur C, Karagas MR, Marsit CJ, Moore JH, Andrew AS, Srivastava A. 2014. Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. Mod Pathol 27:145-155. doi:10.1038/modpathol.2013.104 PMID:23868178 PMCID:PMC3880603
• Langevin SM, Houseman EA, Accomando WP, Koestler DC, Christensen BC, Nelson HH, Karagas MR, Marsit CJ, Wiencke JK, Kelsey KT. 2014. Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients. Epigenetics 9(6):884-895. doi:10.4161/epi.28575 PMID:24671036 PMCID:PMC4065186

2012

• Andrew AS, Hu T, Gu J, Gui J, Ye Y, Marsit CJ, Kelsey KT, Schned AR, Tanyos SA, Pendleton EM, Mason RA, Morlock EV, Zens MS, Li Z, Moore JH, Wu X, Karagas MR. 2012. HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. PLoS One 7(12):e51301. doi:10.1371/journal.pone.0051301 PMID:23284679 PMCID:PMC3526593
• Karagas MR, Andrew AS, Nelson HH, Li Z, Punshon T, Schned AR, Marsit CJ, Morris J, Moore JH, Tyler AL, Gilbert-Diamond D, Guerinot ML, Kelsey KT. 2012. SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer. Hum Genet 131:453-461. doi:10.1007/s00439-011-1090-x PMID:21947419 PMCID:PMC3278547
• Lesseur C, Gilbert-Diamond D, Andrew AS, Ekstrom RM, Li Z, Kelsey KT, Marsit CJ, Karagas MR. 2012. A case-control study of polymorphisms in zenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. Toxicol Lett 210:100-106. doi:10.1016/j.toxlet.2012.01.015 PMID:22306368 PMCID:PMC3374400
• Nelson HH, Marsit CJ, Christensen BC, Houseman E, Kontic M, Wiemels JL, Karagas MR, Zheng S, Wiencke JK, Kelsey KT. 2012. Key epigenetic changes associated with lung cancer development: results from dense methylation array profiling. Epigenetics 7(6):559-566. doi:10.4161/epi.20219 PMID:22522909 PMCID:PMC3398985

2011

• Avissar-Whiting M, Koestler DC, Houseman EA, Christensen BC, Kelsey KT, Marsit CJ. 2011. Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. Epigenetics 6:703-709. doi:10.4161/epi.6.6.16158 PMID:21610323 PMCID:PMC3230543 (Completed with ARRA Funds)
• Banister CE, Koestler DC, Maccani MA, Houseman EA, Padbury JF, Marsit CJ. 2011. Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas. Epigenetics 6:920-927. doi:10.4161/epi.6.7.16079 PMID:21758004 PMCID:PMC3154432 (Completed with ARRA Funds)
• Filiberto AC, Maccani MA, Koestler DC, Wilhelm-Benartzi C, Gagne LA, Marsit CJ. 2011. Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta. Epigenetics 6(5):566-572. doi:10.4161/epi.6.5.15236 PMID:21521940 PMCID:PMC3121971
• Gui J, Moore JH, Kelsey KT, Marsit CJ, Karagas MR, Andrew AS. 2011. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Hum Genet 129(1):101-110. doi:10.1007/s00439-010-0905-5 PMID:20981448 PMCID:PMC3255326 (Completed with ARRA Funds)
• Langevin SM, Houseman EA, Christensen BC, Wiencke JK, Nelson HH, Karagas MR, Marsit CJ, Kelsey KT. 2011. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics 6:908-919. doi:10.4161/epi.6.7.16431 PMID:21617368 PMCID:PMC3154431 (Completed with ARRA Funds)
• Maccani MA, Padbury JF, Marsit CJ. 2011. miR-16 and miR-21 expression in the placenta is associated with fetal growth. PLoS One 6:doi:10.1371/journal.pone.0021210 PMID:21698265 PMCID:PMC3115987 (Completed with ARRA Funds)
• Marsit CJ, Koestler DC, Christensen BC, Karagas MR, Houseman EA, Kelsey KT. 2011. DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer. J Clin Oncol 29(9):1133-1139. doi:10.1200/JCO.2010.31.3577 PMID:21343564 PMCID:PMC3083868 (Completed with ARRA Funds)
• Pacheco SE, Christensen BC, Marsit CJ, Kelsey KT, Sigman M, Boekelheide K. 2011. Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm. PLoS One 6:doi:10.1371/journal.pone.0020280 PMID:21674046 PMCID:PMC3107223 (Completed with ARRA Funds)
• Robins J, Marsit CJ, Padbury J, Sharma S. 2011. Endocrine disruptors, environmental oxygen, epigenetics and pregnancy. Front Biosci (Landmark Ed) 3:690-700. PMID:21196344 PMCID:PMC3050574 (Completed with ARRA Funds)
• Wilhelm-Benartzi C, Christensen BC, Koestler DC, Houseman EA, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2011. Association of secondhand smoke exposures with DNA methylation in bladder carcinomas. Cancer Causes Control 22(8):1205-1213. doi:10.1007/s10552-011-9788-6 PMID:21660454 PMCID:PMC3140591 (Completed with ARRA Funds)

2010

• Avissar-Whiting M, Veiga KR, Uhl KM, Maccani MA, Gagne LA, Moen EL, Marsit CJ. 2010. Bisphenol A exposure leads to specific microRNA alterations in placental cells. Reprod Toxicol 29(4):401-406. doi:10.1016/j.reprotox.2010.04.004 PMID:20417706 PMCID:PMC2896875
• Christensen BC, Smith A, Zheng S, Koestler DC, Houseman E, Marsit CJ, Wiemels JL, Nelson HH, Karagas MR, Wrensch MR, Kelsey KT, Wiencke JK. 2010. DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma. J Natl Cancer Inst 103:143-153. doi:10.1093/jnci/djq497 PMID:21163902 PMCID:PMC3022619
• Gee GV, Koestler DC, Christensen BC, Sugarbaker DJ, Ugolini DJ, Ivaldi GP, Resnick MB, Houseman E, Kelsey KT, Marsit CJ. 2010. Downregulated microRNAs in the differential diagnosis of malignant pleural mesothelioma. Int J Cancer 127(12):2859-2869. doi:10.1002/ijc.25285 PMID:21351265 PMCID:PMC2911512
• Koestler DC, Marsit CJ, Christensen BC, Karagas MR, Bueno R, Sugarbaker DJ, Kelsey KT, Houseman EA. 2010. Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics 26(20):2578-2585. doi:10.1093/bioinformatics/btq470 PMID:20834038 PMCID:PMC2951086 (Completed with ARRA Funds)
• Kwong RC, Karagas MR, Kelsey KT, Mason RA, Tanyos SA, Schned AR, Marsit CJ, Andrew AS. 2010. Arsenic exposure predicts bladder cancer survival in a US population. World J Urol 28(4):487-492. doi:10.1007/s00345-009-0477-y PMID:19834714 PMCID:PMC3296964 (Completed with ARRA Funds)
• Maccani MA, Avissar-Whiting M, Banister CE, McGonnigal B, Padbury J, Marsit CJ. 2010. Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta. Epigenetics 5(7):583-589. doi:10.4161/epi.5.7.12762 PMID:20647767 PMCID:PMC2974801
• Marsit CJ, Houseman EA, Christensen BC, Gagne LA, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Andrew AS, Schned AR, Karagas MR, Kelsey KT. 2010. Identification of methylated genes associated with aggressive bladder cancer. PLoS One 5:e12334. doi:10.1371/journal.pone.0012334 PMID:20808801 PMCID:PMC2925945
• Wilhelm CS, Kelsey KT, Butler RA, Plaza S, Gagne LA, Zens MS, Andrew AS, Morris S, Nelson HH, Schned AR, Karagas MR, Marsit CJ. 2010. Implications of LINE1 methylation for bladder cancer risk in women. Clin Cancer Res 16:1682-1689. doi:10.1158/1078-0432.ccr-09-2983 PMID:20179218 PMCID:PMC2831156
• Wilhelm-Benartzi C, Koestler DC, Houseman E, Christensen BC, Wiencke JK, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2010. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis 31(11):1972-1976. doi:10.1093/carcin/bgq178 PMID:20802236 PMCID:PMC2966555 (Completed with ARRA Funds)

2009

• Andrew AS, Gui J, Sanderson A, Mason RA, Morlock EV, Schned AR, Kelsey KT, Marsit CJ, Moore JH, Karagas MR. 2009. Bladder cancer SNP panel predicts susceptibility and survival. Hum Genet 125(5-6):527-539. doi:10.1007/s00439-009-0645-6 PMID:19252927 PMCID:PMC2763504
• Andrew AS, Mason RA, Kelsey KT, Schned AR, Marsit CJ, Nelson HH, Karagas MR. 2009. DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk. Toxicol Lett 187(1):10-14. doi:10.1016/j.toxlet.2009.01.013 PMID:19429237 PMCID:PMC2680739
• Baris D, Karagas MR, Verrill C, Johnson A, Andrew AS, Marsit CJ, Colt JS, Cherala S, Samanic C, Waddell R, Cantor KP, Schned AR, Rothman N, Lubin JH, Fraumeni JF, Hoover RN, Kelsey KT, Silverman DT, Schwenn M. 2009. A case-control study of smoking and bladder cancer risk: emergent patterns over time. J Natl Cancer Inst 101(22):1553-1561. doi:10.1093/jnci/djp361 PMID:19917915 PMCID:PMC2778671
• Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury J, Bueno R, Sugarbaker DJ, Yeh R, Wiencke JK, Kelsey KT. 2009. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 5(8):e1000602. doi:10.1371/journal.pgen.1000602 PMID:19680444 PMCID:PMC2718614
• Dietrich K, Schned AR, Fortuny J, Heaney JA, Marsit CJ, Kelsey KT, Karagas MR. 2009. Glucocorticoid therapy and risk of bladder cancer. Br J Cancer 101(8):1316-1320. doi:10.1038/sj.bjc.6605314 PMID:19773763 PMCID:PMC2768444
• Maccani MA, Marsit CJ. 2009. Epigenetics in the placenta. Am J Reprod Immunol 62(2):78-89. doi:10.1111/j.1600-0897.2009.00716.x PMID:19614624 PMCID:PMC2813777
• Mason RA, Morlock EV, Karagas MR, Kelsey KT, Marsit CJ, Schned AR, Andrew AS. 2009. EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis. Carcinogenesis 30(7):1155-1160. doi:10.1093/carcin/bgp077 PMID:19372140 PMCID:PMC2704279

2008

• Houseman EA, Christensen BC, Yeh R, Marsit CJ, Karagas MR, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Kelsey KT. 2008. Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Biochem 9:365. doi:10.1186/1471-2105-9-365 PMID:18782434 PMCID:PMC2553421
• Schned AR, Andrew AS, Marsit CJ, Kelsey KT, Zens MS, Karagas MR. 2008. Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States. Scand J Urol Nephrol 42(3):237-42. PMID:18432530
• Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit CJ, Loh ML, Buffler PA, Yeh R. 2008. Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally. Cancer Res 68(23):9935-9944. doi:10.1158/0008-5472.CAN-08-2139 PMID:19047175 PMCID:PMC2597307

2007

• Hsiung DT, Marsit CJ, Houseman EA, Eddy K, Furniss CS, McClean MD, Kelsey KT. 2007. Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 16(1):108-14. PMID:17220338

2006

• Marsit CJ, Eddy K, Kelsey KT. 2006. MicroRNA responses to cellular stress. Cancer Res 66(22):10843-10848. PMID:17108120
• Marsit CJ, Houseman EA, Eddy K, Bueno R, Sugarbaker DJ, Nelson HH, Karagas MR, Kelsey KT, Christensen BC. 2006. Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Res 66(21):10621-9. PMID:17079487
• Marsit CJ, Karagas MR, Danaee H, Liu M, Andrew AS, Schned AR, Nelson HH, Kelsey KT. 2006. Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis 27(1):112-116. PMID:15987713
• Marsit CJ, Karagas MR, Schned AR, Kelsey KT. 2006. Carcinogen exposure and epigenetic silencing in bladder cancer. Ann N Y Acad Sci 1076:810-821. doi:10.1196/annals.1371.031 PMID:17119258

2005

• Hirao S, Hirao T, Hirao Y, Marsit CJ, Schned AR, Devi-Ashok T, Nelson HH, Andrew AS, Karagas MR, Kelsey KT. 2005. Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer 104(9):1918-1923. doi:10.1002/cncr.21423 PMID:16149093
• Marsit CJ, Karagas MR, Andrew AS, Liu M, Danaee H, Schned AR, Nelson HH, Kelsey KT. 2005. Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer. Cancer Res 65(16):7081-7085. PMID:16103055

2003

• Wiencke JK, Zheng S, Smith MT, Zhang L, Ma X, Wiemels JL, Marsit CJ, Kelsey KT, Buffler PA. 2003. Methylation of transcribed PTEN pseudogene in pediatric leukemia is associated with subtypes of common ALL containing t(12;21) translocation. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.