Superfund Research Program

John J. LaPres

Michigan State University
Department of Biochemistry and Molecular Biology
603 Wilson Road, Room 224
Biochemistry Building
East Lansing, Michigan 48824-1319
Phone: 517-432-9282
Fax: 517-353-9334
Email: lapres@msu.edu

Projects

• Michigan State University: A Proteomic Analysis of the AHR signaling Network (2006-2013)
• Michigan State University: An Integrated Experimental and Computational Approach to Understand the Effects of Population Variability on the Shape of the Dose-Response Curve (2006-2021)

Publications

2023

• Jurgelewicz A, Nault R, Harkema JR, Zacharewski TR, LaPres JJ. 2023. Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity. Sci Rep 13(1):16598. doi:10.1038/s41598-023-42972-8 PMID:37789023 PMCID:PMC10547718
• Steidmann MM, Liu J, Bayes K, Castro LP, Ferguson-Miller S, LaPres JJ. 2023. Evidence for crosstalk between the aryl hydrocarbon receptor and the translocator protein in mouse lung epithelial cells. Exp Cell Res 429(1):113617. doi:10.1016/j.yexcr.2023.113617 PMID:37172753 PMCID:PMC10330775

2021

• Warren M, Radulescu A, Dornbos P, Cuomo D, Zumwalt S, Bueso-Mendoza D, Nitcher M, LaPres JJ, Threadgill DW. 2021. Peanut butter as an alternative dose delivery method to prevent strain-dependent orogastric gavage-induced stress in mouse teratogenicity studies. J Pharmacol Toxicol Methods 107:106948. doi:10.1016/j.vascn.2020.106948 PMID:33387613

2020

• Dornbos P, Arkatkar A, LaPres JJ. 2020. An automated method to predict mouse gene and protein sequences using variant data. G3 (Bethesda) 10(3):925-932. doi:10.1534/g3.119.400983 PMID:31911484 PMCID:PMC7056971

2019

• Dornbos P, Jurgelewicz A, Fader KA, Williams K, Zacharewski TR, LaPres JJ. 2019. Characterizing the role of HMG-CoA reductase in aryl hydrocarbon receptor-mediated liver injury in C57BL/6 mice. Sci Rep 9(1):15828. doi:10.1038/s41598-019-52001-2 PMID:31676775 PMCID:PMC6825130

2018

• Dornbos P, LaPres JJ. 2018. Incorporating population-level genetic variability within laboratory models in toxicology: From the individual to the population. Toxicology 395:1-8. doi:10.1016/j.tox.2017.12.007 PMID:29275117 PMCID:PMC5801153
• Dornbos P, Warren M, Crawford RB, Kaminski NE, Threadgill DW, LaPres JJ. 2018. Characterizing Serpinb2 as a modulator of TCDD-induced suppression of the B cell. Chem Res Toxicol 31(11):1248-1259. doi:10.1021/acs.chemrestox.8b00225 PMID:30339366 (ahead of print)

2016

• Dornbos P, Crawford RB, Kaminski NE, Hession SL, LaPres JJ. 2016. The influence of human interindividual variability on the low-dose region of dose-response curve induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in primary B cells. Toxicol Sci 153(2):352-360. doi:10.1093/toxsci/kfw128 PMID:27473338 PMCID:PMC5036619
• Hwang HJ, Dornbos P, LaPres JJ. 2016. Data on AHR-dependent changes in the mitochondrial proteome in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Data Brief 8:191-195. doi:10.1016/j.dib.2016.05.023 PMID:27331086 PMCID:PMC4898910
• Hwang HJ, Dornbos P, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ. 2016. Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol 304:121-132. doi:10.1016/j.taap.2016.04.005 PMID:27105554 PMCID:PMC4930739
• Hwang HJ, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ. 2016. Data of enzymatic activities of the electron transport chain and ATP synthase complexes in mouse hepatoma cells following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Data Brief 8:93-97. doi:10.1016/j.dib.2016.05.018 PMID:27284569 PMCID:PMC4887554

2010

• Forgacs AL, Burgoon LD, Lynn SG, LaPres JJ, Zacharewski TR. 2010. Effects of TCDD on the expression of nuclear encoded mitochondrial genes. Toxicol Appl Pharmacol 246(1-2):58-65. doi:10.1016/j.taap.2010.04.006 PMID:20399798 PMCID:PMC4030424
• Saini Y, Greenwood K, Merrill C, Kim KY, Patial S, Parameswaran N, Harkema JR, LaPres JJ. 2010. Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1 alpha in modulating inflammation. Toxicol Sci 116:673-681. doi:10.1093/toxsci/kfq155 PMID:20511350 PMCID:PMC2905409
• Saini Y, Lewandowski R, Bramble L, Harkema JR, LaPres JJ, Kim KY. 2010. Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. Am J Physiol 298(2):L139-L147. doi:10.1152/ajplung.00252.2009 PMID:19915160 PMCID:PMC2822559

2009

• Wang B, Bobe G, Bourquin LD, LaPres JJ. 2009. High sucrose diets promote intestinal epithelial cell proliferation and tumorigenesis in APC(Min) mice by increasing insulin and IGF-I levels. Nutr Cancer 61(1):81-93. doi:10.1080/01635580802372609 PMID:19116878
• Wang B, Bobe G, LaPres JJ, Bourquin LD. 2009. Dietary carbohydrate source alters gene expression profile of intestinal epithelium in mice. Nutr Cancer 61(1):146-155. doi:10.1080/01635580802372617 PMID:19116885

2008

• Lee K, Lynd JD, O'Reilly S, Kiupel M, McCormick JJ, LaPres JJ. 2008. The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Mol Cancer Res 6(5):829-842. doi:10.1158/1541-7786.MCR-07-2113 PMID:18505927
• Saini Y, Harkema JR, LaPres JJ. 2008. HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. J Biol Chem 283(48):33650-33657. doi:10.1074/jbc.M805927200 PMID:18801745 PMCID:PMC2586263

2007

• Lee K, Roth RA, LaPres JJ. 2007. Hypoxia, therapeutics, and toxicity. J Pharmacol Exp Ther 113(2):229-46. PMID:17046066

2006

• Lee K, Burgoon LD, Lamb L, Dere E, Zacharewski TR, Hogenesch JB, LaPres JJ. 2006. Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades. Chem Res Toxicol 19(10):1284-1293. doi:10.1021/tx060068d PMID:17040097 PMCID:PMC3152583