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Person Details: Melvin E. Andersen

Superfund Research Program

Melvin E. Andersen

ScitoVation LLC
Division of Computational Biology
6 Davis Drive, P.O. Box 12137
Research Triangle Park, North Carolina 27709
Phone: 919-558-1205
Fax: 919-558-1300




  • Filipovic D, Qi W, Kana O, Marri D, LeCluyse EL, Andersen ME, Cuddapah S, Bhattacharya S. 2023. Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants. Toxicol Sci 196(2):170-186. doi:10.1093/toxsci/kfad094 PMID:37707797 PMCID:PMC10682972


  • Josyula N, Andersen ME, Kaminski NE, Dere E, Zacharewski TR, Bhattacharya S. 2019. Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver. Arch Toxicol 94:113-126. doi:10.1007/s00204-019-02620-5 PMID:31728591
  • Zhang Q, Caudle W, Pi J, Bhattacharya S, Andersen ME, Kaminski NE, Conolly RB. 2019. Embracing systems toxicology at single-cell resolution. Curr Opin Toxicol 16:49-57. doi:10.1016/j.cotox.2019.04.003 PMID:31768481 PMCID:PMC6876623


  • Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton K, DeVito MJ, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper SC, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. 2016. The next generation of risk assessment multi-year study-highlights of findings, applications to risk assessment, and future directions. Environ Health Perspect 124(11):1671-1682. doi:10.1289/ehp233 PMID:27091369 PMCID:PMC5089888


  • Zhang Q, Bhattacharya S, Clewell RA, Carmichael PL, Andersen ME. 2015. Adaptive posttranslational control in cellular stress response pathways and its relationship to toxicity testing and safety assessment. Toxicol Sci 147(2):302-316. doi:10.1093/toxsci/kfv130 PMID:26408567 PMCID:PMC4707198


  • Kleensang A, Maertens A, Rosenberg M, Fitzpatrick S, Lamb J, Auerbach SS, Brennan R, Crofton K, Gordon B, Fornace AJ, Gaido KW, Gerhold D, Haw R, Henney A, Ma'ayan A, McBride M, Monti S, Ochs MF, Pandey A, Sharan R, Stierum R, Tugendreich S, Willett C, Wittwehr C, Xia J, Patton GW, Arvidson K, Bouhifd M, Hogberg HT, Luechtefeld T, Smirnova L, Zhao L, Adeleye Y, Kanehisa M, Carmichael PL, Andersen ME, Hartung T. 2014. t4 workshop report: Pathways of toxicity. ALTEX 31(1):53-61. doi:10.14573/altex.1309261 PMID:24127042 PMCID:PMC4041485
  • Zhang Q, Bhattacharya S, Conolly RB, Clewell H, Andersen ME. 2014. Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses. Environ Health Perspect 122(12):1261-1270. doi:10.1289/ehp.1408244 PMID:25117432 PMCID:PMC4256703



  • Campbell J, Clewell RA, Gentry PR, Andersen ME, Clewell H. 2012. Physiologically based pharmacokinetic/toxicokinetic modeling. Chapter 18 in: Computational Toxicology: Methods in Molecular Biology. Humana Press, New York, NY. pp.439-499.


  • Andersen ME, Clewell H, Carmichael PL, Boekelheide K. 2011. Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?". ALTEX 28(3):175-182. PMID:21993955 PMCID:PMC3943477 (Completed with ARRA Funds)
  • Bhattacharya S, Zhang Q, Andersen ME. 2011. Double-negative feedback loops as a common design motif in the transcriptional networks regulating cell fate. International Journal of Design Engineering 4:41-57. doi:10.1504/IJDE.2011.041408
  • Bhattacharya S, Zhang Q, Carmichael PL, Boekelheide K, Andersen ME. 2011. Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways. PLoS One 6(6):doi:10.1371/journal.pone.0020887 PMID:21701582 PMCID:PMC3118802 (Completed with ARRA Funds)
  • Tan Y, Clewell H, Campbell J, Andersen ME. 2011. Evaluating pharmacokinetic and pharmacodynamic interactions with computational models in supporting cumulative risk assessment. Int J Environ Res Public Health 8(5):1613-1630. doi:10.3390/ijerph8051613 PMID:21655141 PMCID:PMC3108131


  • Andersen ME, Zhang Q, Bhattacharya S. 2010. Modeling Gene and Protein Expression - Nested Motifs in Cellular and Tissue Response Networks. Chapter 10 in: Quantitative Modeling in Toxicology. John Wiley & Sons, Hoboken, NJ.
  • Bhattacharya S, Conolly RB, Kaminski NE, Thomas RS, Andersen ME, Zhang Q. 2010. A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 115(1):51-65. doi:10.1093/toxsci/kfq035 PMID:20123757 PMCID:PMC2855357
  • Bhattacharya S, Zhang Q, Andersen ME. 2010. Bistable Signaling Motifs and Cell Fate Decisions. Chapter 8 in: Quantitative Modeling in Toxicology. John Wiley & Sons, Hoboken, NJ.
  • Kline DE, Zhang Q, Bhattacharya S, Andersen ME, Conolly RB, Crawford RB, Kaminski NE. 2010. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Suppresses LPS-activated Binary Switching of B Cells to Plasma Cells.
  • Zhang Q, Bhattacharya S, Andersen ME, Conolly RB. 2010. Computational systems biology and dose-response modeling in relation to new directions in toxicity testing. J Environ Sci Health B 13(2-4):253-76. doi:10.1080/10937404.2010.483943 PMID:20574901
  • Zhang Q, Bhattacharya S, Kline DE, Crawford RB, Thomas RS, Kaminski NE, Andersen ME, Conolly RB. 2010. Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin. BMC Syst Biol 4:40. doi:10.1186/1752-0509-4-40 PMID:20359356 PMCID:PMC2859749
  • Zhang Q, Bhattacharya S, Woods CG, Andersen ME. 2010. Ultrasensitive Response Motifs in Biochemical Networks. Chapter 9 in: Quantitative Modeling in Toxicology. John Wiley & Sons, Hoboken, NJ. pp.199-218.
  • Zhang Q, Pi J, Woods CG, Andersen ME. 2010. A systems biology perspective on Nrf2-mediated antioxidant response. Toxicol Appl Pharmacol 244(1):84-97. doi:10.1016/j.taap.2009.08.018 PMID:19716833 PMCID:PMC2837757



  • Kim D, Andersen ME, Chao YE, Egeghy PP, Rappaport SM, Nylander-French LA. 2007. PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene. Environ Health Perspect 115(6):894-901. doi:10.1289/ehp.9778 PMID:17589597 PMCID:PMC1892111
  • Kim D, Andersen ME, Chao YE, Egeghy PP, Rappaport SM, Nylander-French LA. 2007. Prediction of human dermal and inhalation exposures to jet fuel by analysis of a PBTK model. Environ Health Perspect 115(6):894-901.


  • Kim D, Andersen ME, Nylander-French LA. 2006. A dermatotoxicokinetic model of human exposures to jet fuel. Toxicol Sci 93(1):22-33. doi:10.1093/toxsci/kfl048 PMID:16801332
  • Kim D, Andersen ME, Nylander-French LA. 2006. Dermal absorption and penetration of jet fuel components in humans. Toxicol Lett 165(1):11-21. doi:10.1016/j.toxlet.2006.01.009 PMID:16497449
  • Zhang Q, Thomas RS, Kaminski NE, Conolly RB, Andersen ME. 2006. Computational modeling of TCDD disruption of B-cell terminal differentiation. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.


  • Chubb LS, Andersen ME, Broccardo CJ, Legare ME, Billings RE, Dean CE, Hanneman WH. 2004. Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153. Toxicol Pathol 32(4):467-473. PMID:15223772
  • Slikker W, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, David RM, Doerrer NG, Dorman DC, Gaylor DW, Hattis D, Rogers JM, Setzer RW, Swenberg JA, Wallace K, Andersen ME. 2004. Dose-dependent transitions in mechanisms of toxicity. Toxicol Appl Pharmacol 201(3):203-225. PMID:15582645


  • Andersen ME, Ou YC, Yang RH, Conolly RB, Thomas RS, Gustafson DL, Long ME, Dobrev ID, Chubb LS, Xu Y, Lapidot SA. 2003. Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. Toxicol Sci 73(2):301-314. PMID:12700395


  • Andersen ME, Yang RH, French CT, Chubb LS, Dennison JE. 2002. Molecular circuits, biological switches, and nonlinear dose-response relationships. Environ Health Perspect 110(suppl.6):971-978. PMID:12634127
  • Dobrev ID, Andersen ME, Yang RH. 2002. In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane. Environ Health Perspect 110(10):1031-1039. PMID:12361929
  • Liao KH, Dobrev ID, Dennison, Jr. JE, Andersen ME, Reisfeld B, Reardon KF, Campain JA, Wei W, Klein MT, Quann RJ, Yang RH. 2002. Application of biologically based computer modeling to simple or complex mixtures. Environ Health Perspect 110(suppl.6):957-963. PMID:12634125


  • Dobrev ID, Andersen ME, Yang RH. 2001. Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling. Arch Toxicol 75(3):134-144. PMID:11409535
  • Ou YC, Conolly RB, Thomas RS, Xu Y, Andersen ME, Chubb LS, Pitot HC, Yang RH. 2001. A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay. Cancer Res 61(5):1879-1889. PMID:11280742


  • El-Masri HA, Thomas RS, Sabados G, Phillips JK, Constan AA, Benjamin SA, Mehendale HM, Yang RH, Andersen ME. 1996. Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and kepone. Arch Toxicol 70:704-713. PMID:8896716
  • Thomas RS, Yang RH, Morgan DG, Moorman MP, Kermani HR, Sloane RA, O'Connor RW, Adkins, Jr. B, Gargas ML, Andersen ME. 1996. PBPK modeling/Monte Carlo simulation of methylene chloride kinetic changes in mice in relation to age and acute, subchronic, and chronic inhalation exposure. Environ Health Perspect 104(8):858-865. PMID:8875160
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