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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Fred A. Wright

Superfund Research Program

Fred A. Wright

North Carolina State University
2601 Stinson Dr.
Raleigh, North Carolina 27695-0000
Phone: 919-260-2704
Email: fred_wright@ncsu.edu

Projects

Publications

2024

  • Ford L, Lin H, Tsai H, Zhou Y, Wright FA, Sedykh A, Shah R, Chiu WA, Rusyn I. 2024. Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types. Toxicology 503:153763. doi:10.1016/j.tox.2024.153763 PMID:38423244
  • Tsai H, Ford L, Chen Z, Dickey AN, Wright FA, Rusyn I. 2024. Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes. ALTEX doi:10.14573/altex.2311031 PMID:38429992

2023

  • Cordova AC, Dodds J, Tsai H, Lloyd D, Roman-Hubers AT, Wright FA, Chiu WA, McDonald TJ, Zhu R, Newman G, Rusyn I. 2023. Application of ion mobility spectrometry-mass spectrometry for compositional characterization and fingerprinting of a library of diverse crude oil samples. Environ Toxicol Chem doi:10.1002/etc.5727 PMID:37530422
  • Cordova AC, Klaren WD, Ford L, Grimm FA, Baker ES, Zhou Y, Wright FA, Rusyn I. 2023. Integrative chemical-biological grouping of complex high production volume substances from lower olefin manufacturing streams. Toxics 11(7):586. doi:10.3390/toxics11070586 PMID:37505552 PMCID:PMC10385386
  • Rusyn I, Wright FA. 2023. Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and associations. Toxicol Sci doi:10.1093/toxsci/kfad134 PMID:38141214
  • Sakolish C, Moyer HL, Tsai H, Ford L, Dickey AN, Wright FA, Han G, Bajaj P, Baltazar MT, Carmichael PL, Stanko JP, Ferguson SS, Rusyn I. 2023. Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity. Toxicol Sci doi:10.1093/toxsci/kfad080 PMID:37555834
  • Tsai H, House JS, Wright FA, Chiu WA, Rusyn I. 2023. A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo. Toxicol Sci doi:10.1093/toxsci/kfad041 PMID:37079747 PMCID:PMC10230285

2022

  • Bhandari S, Casillas GA, Aly NA, Zhu R, Newman G, Wright FA, Miller A, Adler G, Rusyn I, Chiu WA. 2022. Spatial and temporal analysis of impacts of Hurricane Florence on criteria air pollutants and air toxics in eastern North Carolina. Int J Environ Res Public Health 19(3):doi:10.3390/ijerph19031757 PMID:35162780 PMCID:PMC8835244
  • Boysen G, Rusyn I, Chiu WA, Wright FA. 2022. Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice. Regul Toxicol Pharmacol doi:10.1016/j.yrtph.2022.105171 PMID:35469930
  • Ford L, Jang S, Chen Z, Zhou Y, Gallins P, Wright FA, Chiu WA, Rusyn I. 2022. A population-based human in vitro approach to quantify inter-individual variability in responses to chemical mixtures. Toxics 10(8):441. doi:10.3390/toxics10080441 PMID:36006120
  • House JS, Dalzell A, Kuchi S, Zhang S, Lenz K, Boogard PJ, Ketelslegers HB, Gant TW, Rusyn I, Wright FA, Grimm FA, Klaren WD. 2022. Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays. ALTEX doi:10.14573/altex.2107051 PMID:35288757
  • Roman-Hubers AT, Cordova AC, Rohde A, Chiu WA, McDonald TJ, Wright FA, Dodds J, Baker ES, Rusyn I. 2022. Characterization of compositional variability in petroleum substances. Fuel 317:doi:10.1016/j.fuel.2022.123547 PMID:35250041 PMCID:PMC8896784
  • Rusyn I, Chiu WA, Wright FA. 2022. Model systems and organisms for addressing inter- and intra-species variability in risk assessment. Regul Toxicol Pharmacol 132:105197. doi:10.1016/j.yrtph.2022.105197 PMID:35636685
  • Zhou Y, Gallins P, Etheridge AS, Jima DD, Scholl EH, Wright FA, Innocenti F. 2022. A resource for integrated genomic analysis of the human liver. Sci Rep 12(1):15151. doi:10.1038/s41598-022-18506-z PMID:36071064 PMCID:PMC9452507

2021

  • Chen Z, Jang S, Kaihatu JM, Zhou Y, Wright FA, Chiu WA, Rusyn I. 2021. Potential human health hazard of post-Hurricane Harvey sediments in Galveston Bay and Houston Ship Channel: A case study of using in vitro bioactivity data to inform risk management decisions. Int J Environ Res Public Health 18:doi:10.3390/ijerph182413378 PMID:34948986 PMCID:PMC8702027
  • Chen Z, Lloyd D, Zhou Y, Chiu WA, Wright FA, Rusyn I. 2021. Risk characterization of environmental samples using in vitro bioactivity and polycyclic aromatic hydrocarbon (PAH) concentrations data. Toxicol Sci 179(1):108-120. doi:10.1093/toxsci/kfaa166 PMID:33165562 PMCID:PMC7797768
  • Erber L, Goodman S, Wright FA, Chiu WA, Tretyakova N, Rusyn I. 2021. Intra- and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl)guanine adducts following inhalation exposure to 1,3-butadiene. Chem Res Toxicol 34(11):2375-2383. doi:10.1021/acs.chemrestox.1c00291 PMID:34726909 PMCID:PMC8715497
  • House JS, Grimm FA, Klaren WD, Dalzell A, Kuchi S, Zhang S, Lenz K, Boogaard PJ, Ketelslegers HB, Gant TW, Wright FA, Rusyn I. 2021. Grouping of UVCB substances with new approach methodologies (NAMs) data. ALTEX 38:123-137. doi:10.14573/altex.2006262 PMID:33086383 PMCID:PMC7900923
  • Luo Y, Chen Z, Blanchette A, Zhou Y, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Food Chem Toxicol doi:10.1016/j.fct.2021.111979 PMID:33450301
  • Marvel S, House JS, Wheeler M, Song K, Zhou Y, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2021. The COVID-19 Pandemic Vulnerability Index (PVI) dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. Environ Health Perspect 129:17701. doi:10.1289/EHP8690 PMID:33400596 PMCID:PMC7785295
  • Roman-Hubers AT, Cordova AC, Aly NA, McDonald TJ, Lloyd D, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Data processing workflow to identify structurally related compounds in petroleum substances using ion mobility spectrometry-mass spectrometry. Energy Fuels 35:10529-10539. doi:10.1021/acs.energyfuels.1c00892 PMID:34366560 PMCID:PMC8341389
  • Wang M, Rivenbark K, Gong J, Wright FA, Phillips TD. 2021. Application of edible montmorillonite clays for the adsorption and detoxification of microcystin. ACS Appl Bio Mater 4(9):7254-7265. doi:10.1021/acsabm.1c00779

2020

2019

  • Burnett SD, Blanchette A, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. 2019. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol 381:114711. doi:10.1016/j.taap.2019.114711 PMID:31425687 PMCID:PMC6745256
  • Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. 2019. Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers. Regul Toxicol Pharmacol 101:91-102. doi:10.1016/j.yrtph.2018.11.011 PMID:30471335 PMCID:PMC6333527
  • Lewis L, Borowa-Mazgaj B, de Conti A, Chappell G, Luo Y, Bodnar WM, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. 2019. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chem Res Toxicol 32(5):doi:10.1021/acs.chemrestox.9b00035 PMID:30990016 (ahead of print)
  • Luo Y, Cichocki JA, Hsieh N, Lewis L, Wright FA, Threadgill DW, Chiu WA, Rusyn I. 2019. Using Collaborative Cross mouse population to fill data gaps in risk assessment: A case study of population-based analysis of toxicokinetics and kidney toxicodynamics of tetrachloroethylene. Environ Health Perspect 127(6):67011. doi:10.1289/EHP5105 PMID:31246107 PMCID:PMC6792382
  • Mukherjee R, Onel M, Beykal B, Szafran AT, Stossi F, Mancini MA, Zhou L, Wright FA, Pistikopoulos EN. 2019. Development of the Texas A&M Superfund Research Program computational platform for data integration, visualization, and analysis. Computer Aided Chemical Engineering 46:967-972. doi:10.1016/B978-0-12-818634-3.50162-4 PMID:31612156 PMCID:PMC6791821
  • Onel M, Beykal B, Ferguson K, Chiu WA, McDonald TJ, Zhou L, House JS, Wright FA, Sheen D, Rusyn I, Pistikopoulos EN. 2019. Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization. PLoS One 14(10):e0223517. doi:10.1371/journal.pone.0223517 PMID:31600275 PMCID:PMC6786635

2018

2017

  • House JS, Grimm FA, Jima DD, Zhou Y, Rusyn I, Wright FA. 2017. A pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics. Front Genet 8:168. doi:10.3389/fgene.2017.00168 PMID:29163636 PMCID:PMC5672545
  • Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065 PMID:28369613
  • Zhou Y, Cichocki JA, Soldatow VY, Scholl EH, Gallins P, Jima DD, Yoo HS, Chiu WA, Wright FA, Rusyn I. 2017. Editor's highlight: comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse. Toxicol Sci 160(1):95-110. doi:10.1093/toxsci/kfx165 PMID:28973375 PMCID:PMC5837274

2016

  • Grimm FA, Iwata Y, Sirenko O, Chappell G, Wright FA, Reif DM, Braisted JA, Gerhold D, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde A, Rusyn I. 2016. A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. Green Chem 18(16):4407-4419. doi:10.1039/c6gc01147k PMID:28035192 PMCID:PMC5179981
  • Singleton D, Dickey AN, Scholl EH, Wright FA, Aitken MD. 2016. Complete genome sequence of a bacterium representing a deep uncultivated lineage within the gammaproteobacteria associated with the degradation of polycyclic aromatic hydrocarbons. Genome Announc 4(5):e01086-e01116. doi:10.1128/genomeA.01086-16 PMID:27795254 PMCID:PMC5054325
  • Tian X, Patel K, Ridpath JR, Chen Y, Zhou Y, Neo D, Clement JM, Takata M, Takeda S, Sale J, Wright FA, Swenberg JA, Nakamura J. 2016. Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium. PLoS One 11(12):e0167503. doi:10.1371/journal.pone.0167503 PMID:27907204 PMCID:PMC5132242

2015

  • Abdo N, Wetmore BA, Chappell G, Shea D, Wright FA, Rusyn I. 2015. In vitro screening for population variability in toxicity of pesticide-containing mixtures. Environ Int 85:147-155. doi:10.1016/j.envint.2015.09.012 PMID:26386728 PMCID:PMC4773193
  • Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou Y, Jack J, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif A, Austin CP, Tice RR, Rusyn I, Wright FA. 2015. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect 123(5):458-466. doi:10.1289/ehp.1408775 PMID:25622337 PMCID:PMC4421772
  • Eduati F, Mangravite LM, Wang T, Tang H, Bare J, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y. 2015. Prediction of human population responses to toxic compounds by a collaborative competition. Nat Biotechnol 33(9):933-940. PMID:26258538
  • Rager JE, Tilley SK, Tulenko SE, Smeester L, Ray PD, Yosim A, Currier JM, Ishida MC, del Carmen Gonzalez-Horta M, Sanchez-Ramirez B, Ballinas-Casarrubias L, Gutierrez-Torres DS, Drobna Z, Del Razo LM, Garcia-Vargas GG, Kim WY, Zhou Y, Wright FA, Styblo M, Fry RC. 2015. Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol 28(6):1144-1155. doi:10.1021/tx500393y PMID:26039340 PMCID:PMC4748849
  • Singleton D, Dickey AN, Scholl EH, Wright FA, Aitken MD. 2015. Complete genome sequence of a novel bacterium within the family Rhodocyclaceae that degrades polycyclic aromatic hydrocarbons. Genome Announc 3(2):doi:10.1128/genomeA.00251-15 PMID:25858839 PMCID:PMC4392151
  • Zhou Y, Wright FA. 2015. Hypothesis testing at the extremes: fast and robust association for high-throughput data. Biostatistics 16(3):611-625. doi:10.1093/biostatistics/kxv007 PMID:25792622 PMCID:PMC4804120

2014

  • Chiu WA, Campbell J, Clewell H, Zhou Y, Wright FA, Guyton KZ, Rusyn I. 2014. Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse. Environ Health Perspect 122(5):456-463. doi:10.1289/ehp.1307623 PMID:24518055 PMCID:PMC4014769
  • Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I. 2014. Standardizing benchmark dose calculations to improve science-based decisions in human health assessments. Environ Health Perspect 122(5):499-505. doi:10.1289/ehp.1307539 PMID:24569956 PMCID:PMC4014768
  • Wright FA, Sullivan PF, Brooks AI, Zou F, Sun W, Xia K, Madar V, Jansen R, Chung W, Zhou Y, Abdellaoui A, Batista S, Butler C, Chen G, Chen T, D'Ambrosio D, Gallins P, Ha MJ, Hottenga JJ, Huang S, Kattenberg M, Kochar J, Middeldorp CM, Qu A, Shabalin AA, Tischfield JA, Todd L, Tzeng J, van Grootheest G, Vink JM, Wang Q, Wang W, Wang W, Willemsen G, Smit JH, de Geus EJ, Yin Z, Penninx BW, Boomsma DI. 2014. Heritability and genomics of gene expression in peripheral blood. Nat Genet 46(5):430-437. doi:10.1038/ng.2951 PMID:24728292 PMCID:PMC4012342

2013

  • Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, Young N, Foster B, Moser M, Karasik E, Gillard B, Ramsey K, Sullivan S, Bridge J, Magazine H, Syron J, Fleming J, Siminoff L, Traino H, Mosavel M, Barker L, Jewell S, Rohrer D, Maxim D, Filkins D, Harbach P, Cortadillo E, Berghuis B, Turner L, Hudson E, Feenstra K, Sobin L, Robb J, Branton P, Korzeniewski G, Shive C, Tabor D, Qi L, Groch K, Nampally S, Buia S, Zimmerman A, Smith A, Burges R, Robinson K, Valentino K, Bradbury D, Cosentino M, Diaz-Mayoral N, Kennedy M, Engel T, Williams P, Erickson K, Ardlie K, Winckler W, Getz G, DeLuca D, MacArthur D, Kellis M, Thomson A, Young T, Gelfand E, Donovan M, Meng Y, Grant G, Mash D, Marcus Y, Basile M, Liu J, Zhu J, Tu Z, Cox NJ, Nicolae DL, Gamazon ER, Im HK, Konkashbaev A, Pritchard J, Stevens M, Flutre T, Wen X, Dermitzakis ET, Lappalainen T, Guigo R, Monlong J, Sammeth M, Koller D, Battle A, Mostafavi S, McCarthy M, Rivas M, Maller J, Rusyn I, Nobel AB, Wright FA, Shabalin AA, Feolo M, Sharopova N, Sturcke A, Paschal J, Anderson JM, Wilder EL, Derr LK, Green ED, Struewing JP, Temple G, Volpi S, Boyer JT, Thomson EJ, Guyer MS, Ng C, Abdallah A, Colantuoni D, Insel TR, Koester SE, Little A, Bender PK, Lehner T, Yao Y, Compton CC, Vaught JB, Sawyer S, Lockhart NC, Demchok J, Moore HF. 2013. The Genotype-Tissue Expression (GTEx) project. Nat Genet 45:580-585. doi:10.1038/ng.2653 PMID:23715323 PMCID:PMC4010069
  • Moeller BC, Recio L, Green A, Sun W, Wright FA, Bodnar WM, Swenberg JA. 2013. Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure. Toxicol Sci 133(1):1-12. doi:10.1093/toxsci/kft029 PMID:23425604 PMCID:PMC3627555
  • Reif DM, Sypa M, Lock EF, Wright FA, Wilson A, Cathey T, Judson RR, Rusyn I. 2013. ToxPi GUI: An interactive visualization tool for transparent integration of data from diverse sources of evidence. Bioinformatics 29(3):402-403. doi:10.1093/bioinformatics/bts686 PMID:23202747 PMCID:PMC3988461
  • Sanders AP, Smeester L, Rojas D, DeBussycher T, Wu MC, Wright FA, Zhou Y, Laine JE, Rager JE, Swamy GK, Ashley-Koch A, Miranda ML, Fry RC. 2013. Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs. Epigenetics 9(2):29-38. doi:10.4161/epi.26798 PMID:24169490 PMCID:PMC3962531
  • Zhou Y, Barry WT, Wright FA. 2013. Empirical pathway analysis, without permutation. Biostatistics 14(3):573-585. doi:10.1093/biostatistics/kxt004 PMID:23428933 PMCID:PMC3677738
  • Zhou Y, Mayhew G, Sun Z, Xu X, Zou F, Wright FA. 2013. Space–time clustering and the permutation moments of quadratic forms. Stat 2(1):292-302. doi:10.1002/sta4.37 PMID:25210205 PMCID:PMC4157666

2012

  • Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou Y, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. 2012. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci 126(2):578-588. doi:10.1093/toxsci/kfs023 PMID:22268004 PMCID:PMC3307611
  • Wright FA, Shabalin AA, Rusyn I. 2012. Computational tools for discovery and interpretation of expression quantitative trait loci. Pharmacogenomics 13(3):343-352. doi:10.2217/pgs.11.185 PMID:22304583 PMCID:PMC3295835

2011

2010

  • Sun W, Wright FA. 2010. A geometric interpretation of the permutation p-value and its application in EQTL studies. Annals of Applied Statistics 4:1014-1033. doi:10.1214/09-aoas298

2009

  • Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I. 2009. Replication and narrowing of gene expression quantitative trait loci using inbred mice. Mamm Genome 20(7):437-446. doi:10.1007/s00335-009-9199-0 PMID:19609828 PMCID:PMC2745627
  • Gatti DM, Shabalin AA, Lam T, Wright FA, Rusyn I, Nobel AB. 2009. FastMap: fast eQTL mapping in homozygous populations. Bioinformatics 25(4):482-489. doi:10.1093/bioinformatics/btn648 PMID:19091771 PMCID:PMC2642639
  • Gatti DM, Sypa M, Rusyn I, Wright FA, Barry WT. 2009. SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy. Bioinformatics 25(4):541-542. doi:10.1093/bioinformatics/btn655 PMID:19098030 PMCID:PMC2642635
  • Zhu H, Ye L, Richard A, Golbraikh A, Wright FA, Rusyn I, Tropsha A. 2009. A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents. Environ Health Perspect 117(8):1257-64. PMID:19672406

2008

  • Gatti DM, Shabalin AA, Rusyn I, Wright FA, Nobel AB. 2008. Fast association mapping using summation trees. In: 7th Annual Meeting of the Complex Traits Consortium,. Montreal, Canada.
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