Superfund Research Program

Zhengui Xia

University of Washington
Department of Environmental and Occupational Health Sciences
Health Sciences Building, F-561C
Box 357234
Seattle, Washington 98195
Phone: 206-616-9433
Fax: 206-685-3990
Email: zxia@uw.edu

Projects

• University of Washington: Cellular and Molecular Mechanisms of Cadmium Neurotoxicity (2015-2023)
• University of Washington: Mechanisms and Biomarkers of Metal Olfactory Injury in Salmon (2009-2023)
• University of Washington: Research Translation (2006-2023)
• University of Washington: Training Core (2015-2023)

Research Briefs

• 301 - Cadmium Exposure Impairs Production of Neurons Responsible for Learning and Memory

Publications

2024

• Matsushita MT, Xia Z. 2024. Cadmium inhibits calcium activity in hippocampal CA1 neurons of freely moving mice. Toxicol Sci doi:10.1093/toxsci/kfae048

2023

• Matsushita MT, Wang H, Abel GM, Xia Z. 2023. Inducible and conditional activation of adult neurogenesis rescues cadmium-induced hippocampus-dependent memory deficits in ApoE4-KI mice. Int J Mol Sci 24(11):9118. doi:10.3390/ijms24119118 PMID:37298071 PMCID:PMC10253189

2022

• Wang H, Zhang L, Xia Z, Cui JY. 2022. Effect of chronic cadmium exposure on brain and liver transporters and drug-metabolizing enzymes in male and female mice genetically predisposed to Alzheimer's disease. Drug Metab Dispos 50(10):1414-1428. doi:10.1124/dmd.121.000453 PMID:35878927 PMCID:PMC9513859

2021

• Wang H, Abel GM, Storm D, Xia Z. 2021. Adolescent cadmium exposure impairs cognition and hippocampal neurogenesis in C57BL/6 mice. Environ Toxicol 37(2):doi:10.1002/tox.23402 PMID:34741586 (ahead of print)
• Zhang A, Matsushita MT, Zhang L, Wang H, Shi X, Gu H, Xia Z, Cui JY. 2021. Cadmium exposure modulates the gut-liver axis in an Alzheimers disease mouse model. Commun Biol 4:doi:10.1038/s42003-021-02898-1 PMID:34912029 PMCID:PMC8674298

2020

• Wang H, Matsushita MT, Abel GM, Storm D, Xia Z. 2020. Inducible and conditional activation of ERK5 MAP kinase rescues mice from cadmium-induced olfactory memory deficits. Neurotoxicology 81:127-136. doi:10.1016/j.neuro.2020.09.038 PMID:33039505 PMCID:PMC7708515
• Wang H, Matsushita MT, Zhang L, Abel GM, Mommer BC, Huddy T, Storm D, Xia Z. 2020. Inducible and conditional stimulation of adult hippocampal neurogenesis rescues Cadmium-induced impairments of adult hippocampal neurogenesis and hippocampus-dependent memory in mice. Toxicol Sci 177:263-280. doi:10.1093/toxsci/kfaa104 PMID:32617577 PMCID:PMC7553705

2019

• Wang H, Abel GM, Storm D, Xia Z. 2019. Cadmium exposure impairs adult hippocampal neurogenesis. Toxicol Sci 171:501-514. doi:10.1093/toxsci/kfz152 PMID:31271426
• Zhang L, Chen X, Sindreu C, Lu S, Storm D, Zweifel LS, Xia Z. 2019. Dynamics of a hippocampal neuronal ensemble encoding trace fear memory revealed by in vivo Ca2+ imaging. PLoS One 14(7):e0219152. doi:10.1371/journal.pone.0219152 PMID:31269057 PMCID:PMC6608968
• Zhang L, Wang H, Abel GM, Storm D, Xia Z. 2019. The effects of gene-environment interactions between cadmium exposure and apolipoprotein E4 on memory in a mouse model of alzheimer's disease. Toxicol Sci 173(1):189-201. doi:10.1093/toxsci/kfz218 PMID:31626305

2018

• Wang H, Zhang L, Abel GM, Storm D, Xia Z. 2018. Cadmium exposure impairs cognition and olfactory memory in male C57BL/6 mice. Toxicol Sci 161:87-102. doi:10.1093/toxsci/kfx202 PMID:29029324 PMCID:PMC5837361

2017

• Wang H, Engstrom AK, Xia Z. 2017. Cadmium impairs the survival and proliferation of cultured adult subventricular neural stem cells through activation of the JNK and p38 MAP kinases. Toxicology 380:30-37. doi:10.1016/j.tox.2017.01.013 PMID:28163110 PMCID:PMC5413202
• Xia Z, Storm D. 2017. Role of circadian rhythm and REM sleep for memory consolidation. Neurosci Res 118:13-20. doi:10.1016/j.neures.2017.04.011