Superfund Research Program

Ying Chen

Yale University
60 College St, LEPH 521
New Haven, Connecticut 06520
Phone: 203-785-4694
Email: ying.chen@yale.edu

Projects

• Yale University: Toxicity and Liver Carcinogenicity of 1,4-Dioxane: Single Chemical and Mixtures Studies (2022-2027)

Publications

2022

• Chen Y, Wang Y, Charkoftaki G, Orlicky DJ, Davidson EA, Wan F, Ginsberg GL, Thompson DC, Vasiliou V. 2022. Oxidative stress and genotoxicity in 1,4-doxane liver toxicity as evidence in a mouse model of glutathione deficiency. Sci Total Environ 806(Pt2):150703. doi:10.1016/j.scitotenv.2021.150703 PMID:34600989 PMCID:PMC8633123
• Ginsberg GL, Chen Y, Vasiliou V. 2022. Mechanistic considerations in 1,4-dioxane cancer risk assessment. Current Opinion in Environmental Science & Health 30:100407. doi:10.1016/j.coesh.2022.100407 PMID:37091947
• Wang Y, Charkoftaki G, Davidson EA, Orlicky DJ, Tanguay RL, Thompson DC, Vasiliou V, Chen Y. 2022. Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models. Current Opinion in Environmental Science & Health 29:100389. doi:10.1016/j.coesh.2022.100389

2021

• Charkoftaki G, Golla JP, Santos-Neto A, Orlicky DJ, Garcia-Milian R, Chen Y, Rattray NJ, Cai Y, Wang Y, Shearn CT, Mironova V, Wang Y, Johnson CH, Thompson DC, Vasiliou V. 2021. Identification of dose-dependent DNA damage and repair responses from subchronic exposure to 1,4-dioxane in mice using a systems analysis approach. Toxicol Sci 183(2):338-351. doi:10.1093/toxsci/kfab030 PMID:33693819 PMCID:PMC8921626

2005

• Kann S, Estes C, Reichard JF, Huang M, Sartor MA, Schwemberger S, Chen Y, Dalton TP, Shertzer HG, Xia Y, Puga A. 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol Sci 87(2):365-384. PMID:16014739