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Your Environment. Your Health.

Person Details: Dr. William G. Thilly

Superfund Research Program

Dr. William G. Thilly

Massachusetts Institute of Technology
50 Ames Street, Bldg. E18-666
Cambridge, Massachusetts 02139
Phone: 617-253-6220
Fax: 617-258-5424
Email: thilly@mit.edu

Projects

Research Briefs

Publications

1998

  • Bjorheim J, Lystad S, Lindblom A, Kressner U, Westring S, Wahlberg S, Lindmark G, Gaudernack G, Ekstrom P, Roe J, Thilly WG, Borresen-Dale AL. 1998. Mutation analyses of KRAS exon 1 comparing three different techniques: temporal temperature gradient electrophoresis, constant denaturant capillary electrophoresis and allele specific polymerase chain reaction. Mutat Res 403:103-112. PMID:9726011
  • Coller HA, Khrapko K, Torres A, Frampton MW, Utell MJ, Thilly WG. 1998. Mutational spectra of a 100-base pair mitochondrial DNA target sequence in bronchial epithelial cells: a comparison of smoking and nonsmoking twins. Cancer Res 58(6):1268-1277. PMID:9515815
  • Coller HA, Thilly WG. 1998. Mutational Spectra Technology. In: Encyclopedia of environmental analysis and remediation. Wiley-Interscience, pp.2967-3005.
  • Durant JL, Lafleur AL, Plummer EF, Taghizadeh K, Busby WF, Thilly WG. 1998. Human lymphoblast mutagens in urban airborne particles. Environ Sci Technol 32:1894-1906.
  • Hannigan MP, Cass GR, Penman BW, Crespi CL, Lafleur AL, Busby WF, Thilly WG. 1998. Bioassay-directed chemical analysis of Los Angeles airborne particulate matter using a human cell mutagenicity assay. Environ Sci Technol 32:3502-3514.
  • Herrero-Jimenez P, Thilly G, Southam PJ, Tomita AV, Morgenthaler S, Furth EE, Thilly WG. 1998. Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States. Mutat Res 400:553-578. PMID:9685710
  • Khrapko K, Coller HA, Hanekamp JS, Thilly WG. 1998. Identification of point mutations in mixtures by capillary electrophoresis hybridization. Nucleic Acids Res 26(24):5738-5740. PMID:9838007
  • Li X, Thilly WG. 1998. Scanning technology for point mutants within 100-bp sequences in human blood and tissues. Journal of Disease Gene Identification: Methods and Protocols, a series of Methods in Molecular Medicine
  • Marcelino LA, Andre PC, Khrapko K, Coller HA, Griffith J, Thilly WG. 1998. Chemically induced mutations in mitochondrial DNA of human cells: Mutational spectrum of N-Methyl-N'-nitro-N-nitrosoguanidine. Cancer Res 58:2857-2862. PMID:9661902
  • Tomita AV, Muniappan BP, Herrero-Jimenez P, Zarbl HF, Thilly WG. 1998. Single nucleotide polymorphism spectra in newborns and centenarians: identification of genes coding for risk of mortal disease. Gene 26:381-391. PMID:9858772

1997

  • Hannigan MP, Cass GR, Penman BW, Crespi CL, Lafleur AL, Busby WF, Thilly WG. 1997. Human cell mutagens in Los Angeles air. Environ Sci Technol 31:438-447.
  • Khrapko K, Coller HA, Andre PC, Li X, Hanekamp JS, Thilly WG. 1997. Mitochondrial mutational spectra in human cells and tissues. Proc Natl Acad Sci U S A 94(25):13798-13803. PMID:9391107
  • Rogers CE, Tomita AV, Trowbridge PR, Gone J, Chen J, Zeeb PJ, Hemond HF, Thilly WG, Olmez I, Durant JL. 1997. Hair analysis does not support hypothesized arsenic and chromium exposure from drinking water in Woburn, Massachusetts. Environ Health Perspect 105(10):1090-1097. PMID:9349834

1996

  • Cha RS, Guerra L, Thilly WG, Zarbl HF. 1996. Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats. Carcinogenesis 17(11):2519-2524. PMID:8968072
  • Chen J, Thilly WG. 1996. Mutational spectra vary with exposure conditions: benzo(a)pyrene in human cells. Mutat Res 357(1-2):209-217. PMID:8876696
  • Hanekamp JS, Thilly WG, Chaudry A. 1996. Screening for human mitochondrial DNA polymorphisms with denaturing gradient gel electrophoresis. Hum Genet 98:243-245. PMID:8698353
  • Khrapko K, Coller HA, Thilly WG. 1996. Efficiency of separation of DNA mutations by constant denaturant capillary electrophoresis (CDCE) is controlled by the kinetics of DNA melting equilibrium. Electrophoresis 17(12):1867-1874. PMID:9034768
  • Thilly WG. 1996. On the trail of mutations at MIT. Environ Health Perspect 104(2):142-145.

1995

  • Cha RS, Thilly WG. 1995. Specificity, Efficiency, and Fidelity of PCR. In: PCR Primer A Laboratory Manual. Cold Spring Harbor, NY. pp.37-51.
  • Durant JL, Chen J, Hemond HF, Thilly WG. 1995. Elevated incidence of childhood leukemia in Woburn, Massachusetts: NIEHS Superfund Basic Research Program Search for Causes. Environ Health Perspect 103(Suppl.6):93-98. PMID:8549500
  • Hanekamp JS, Andre PC, Coller HA, Li X, Thilly WG, Khrapko K. 1995. A protocol for constant denaturant capillary electrophoresis (CDCE): Mutant DNA sequence detection. In: Mutation Detection Visby Sweden, Laboratory Protocols. Oxford University Press, pp.38-41.
  • Hanekamp JS, Thilly WG. 1995. Chromatographic separations of genetically altered DNA sequences in humans: Mutational Spectrometry. In: Chromatographic Analysis of Environment, 3rd Edition. Marcel Dekker, Inc, NY.
  • Kumar R, Hanekamp JS, Louhelainen J, Burvall J, Onfelt A, Hemminki K, Thilly WG. 1995. Separation of transforming amino acid-substituting mutations in codons 12, 13 and 61 the N-ras gene by constant denaturant capillary electrophoresis (CDCE). Carcinogenesis 16(11):2667-2673. PMID:7586184
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