Superfund Research Program

Kai Wang

University of Iowa
Department of Biostatistics
C22-BGH
University of Iowa
Iowa City, Iowa 52242
Phone: 319-384-5175
Email: kai-wang@uiowa.edu

Projects

• University of Iowa: Data Management and Analysis Core (2020-2025)

Publications

2023

• Roh T, Knappett PS, Han D, Ludewig G, Kelly KM, Wang K, Weyer P. 2023. Characterization of arsenic and atrazine contaminations in drinking water in Iowa: a public health concern. Int J Environ Res Public Health 20(7):5397. doi:10.3390/ijerph20075397 PMID:37048011 PMCID:PMC1009410

2022

• Li X, Hefti MM, Marek RF, Hornbuckle KC, Wang K, Lehmler H. 2022. Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: Age and brain region differences. Environ Sci Technol 56(13):9515-9526. doi:10.1021/acs.est.2c00581 PMID:35658127 PMCID:PMC9260965
• Li X, Lim JJ, Wang K, Prasad B, Bhatt D, Cui JY, Lehmler H. 2022. The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. Environ Toxicol Pharmacol 92:103854. doi:10.1016/j.etap.2022.103854 PMID:35331926 PMCID:PMC9090986
• Zhang D, Saktrakulkla P, Marek RF, Lehmler H, Wang K, Thorne PS, Hornbuckle KC, Duffel MW. 2022. PCB sulfates in serum from mothers and children in urban and rural US communities. Environ Sci Technol doi:10.1021/acs.est.2c00223 PMID:35500099 PMCID:PMC9118556

2021

• Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo D, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. 2021. Response to: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. Am J Physiol Endocrinol Metab doi:10.1152/ajpendo.00119.2021 PMID:33843283
• Zhang D, Saktrakulkla P, Tuttle K, Marek RF, Lehmler H, Wang K, Hornbuckle KC, Duffel MW. 2021. Detection and quantification of polychlorinated biphenyl sulfates in human serum. Environ Sci Technol 55:2473-2481. doi:10.1021/acs.est.0c06983 PMID:33502843 PMCID:PMC7924310

2020

• Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo D, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. 2020. Exposure to static magnetic and electric fields treats type 2 diabetes. Cell Metab 32:561-574. doi:10.1016/j.cmet.2020.09.012 PMID:33027675
• Li X, Zhang C, Wang K, Lehmler H. 2020. Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorinated biphenyls (PCBs) in mice with a liver-specific deletion of cytochrome P450 reductase. Environ Pollut 266:115233. doi:10.1016/j.envpol.2020.115233 PMID:32712482 PMCID:PMC7492420

2019

• Wang K, Vasylieva N, Wan D, Eads DA, Yang J, Tretten T, Barnych B, Li J, Li QX, Gee SJ, Hammock BD, Xu T. 2019. Quantitative detection of fipronil and fipronil-sulfone in sera of black-tailed prairie dogs and rats after oral exposure to fipronil by camel single-domain antibody-based immunoassays. Anal Chem 91:1532-1540. doi:10.1021/acs.analchem.8b04653

2018

• He J, Tian J, Xu J, Wang K, Li J, Gee SJ, Hammock BD, Li QX, Xu T. 2018. Strong and oriented conjugation of nanobodies onto magnetosomes for the development of a rapid immunomagnetic assay for the environmental detection of tetrabromobisphenol-A. Anal Bioanal Chem 410(25):6633-6642. doi:10.1007/s00216-018-1270-9 PMID:30066195
• Liang Y, Lang AL, Zhang J, Chen J, Wang K, Chen L, Beier JI, Qian Y, Cai L. 2018. Exposure to vinyl chloride and its influence on western diet-induced cardiac remodeling. Chem Res Toxicol 31:482-493. doi:10.1021/acs.chemrestox.8b00043 PMID:29727174 PMCID:PMC6167925

2017

• Kania-Korwel I, Wu X, Wang K, Lehmler H. 2017. Identification of lipidomic markers of chronic 3,3 ,4,4 ,5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver. Toxicology 390:124-134. doi:10.1016/j.tox.2017.09.005 PMID:28890136 PMCID:PMC5633524
• Lynch CF, Kelly KM, Ludewig G, Wang K, Roh T, Weyer P. 2017. Low-level arsenic exposure from drinking water is associated with prostate cancer in Iowa. Environ Res 159:338-343. doi:10.1016/j.envres.2017.08.026 PMID:28841521 PMCID:PMC5623650

2016

• Koh W, Hornbuckle KC, Wang K, Thorne PS. 2016. Serum polychlorinated biphenyls and their hydroxylated metabolites are associated with demographic and behavioral factors in children and mothers. Environ Int 94:538-545. doi:10.1016/j.envint.2016.06.014 PMID:27352881 PMCID:PMC4980156
• Koh WX, Hornbuckle KC, Marek RF, Wang K, Thorne PS. 2016. Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two US Midwestern communities. Chemosphere 147:389-395. doi:10.1016/j.chemosphere.2015.12.113 PMID:26774304 PMCID:PMC4747419
• Wang B, Klaren WD, Wels B, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G. 2016. Dietary manganese modulates PCB126 toxicity, metal status, and MnSOD in the rat. Toxicol Sci 150(1):15-26. doi:10.1093/toxsci/kfv312 PMID:26660635 PMCID:PMC5009614

2013

• Lai IK, Klaren WD, Li M, Wels B, Simmons DL, Olivier AK, Haschek-Hock WM, Wang K, Ludewig G, Robertson LW. 2013. Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver?. Chem Res Toxicol 26(5):634-644. doi:10.1021/tx400049s PMID:23527585 PMCID:PMC3660509
• Marek RF, Thorne PS, Wang K, DeWall J, Hornbuckle KC. 2013. PCBs and OH-PCBs in serum from children and mothers in urban and rural U.S. communities. Environ Sci Technol 47(7):3353-3361. doi:10.1021/es304455k PMID:23452180 PMCID:PMC3645264

2011

• Lai IK, Chai Y, Simmons DL, Watson WH, Tan R, Haschek-Hock WM, Wang K, Wang B, Ludewig G, Robertson LW. 2011. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicol Sci 124:202-214. doi:10.1093/toxsci/kfr215 PMID:21865291 PMCID:PMC3196656
• Wang B, Robertson LW, Wang K, Ludewig G. 2011. Species difference in the regulation of cytochrome P450 2S1: lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126. Xenobiotica 41:1031-1043. doi:10.3109/00498254.2011.603763 PMID:21970748 PMCID:PMC3564674

2010

• Jacobus JA, Wang B, Maddox C, Esch HL, Lehmann L, Robertson LW, Wang K, Kirby PA, Ludewig G. 2010. 3-Methylcholanthrene (3-MC) and 4-chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats. Environ Int 36(8):970-979. doi:10.1016/j.envint.2010.07.006 PMID:20739065 PMCID:PMC2949545
• Lehmler H, Martinez A, Wang K, Hornbuckle KC, Hu D. 2010. Atmospheric PCB congeners across Chicago. Atmos Environ (1994) 44(12):1550-1557. doi:10.1016/j.atmosenv.2010.01.006 PMID:21918637 PMCID:PMC3171135
• Martinez A, Norstrom K, Wang K, Hornbuckle KC. 2010. Polychlorinated biphenyls in the surficial sediment of Indiana Harbor and Ship Canal, Lake Michigan. Environ Int 36(8):849-854. doi:10.1016/j.envint.2009.01.015 PMID:19268364 PMCID:PMC2888873
• Martinez A, Wang K, Hornbuckle KC. 2010. Fate of PCB congeners in an industrial harbor of Lake Michigan. Environ Sci Technol 44:2803-2808. doi:10.1021/es902911a PMID:20131898 PMCID:PMC3257175

2008

• Maddox C, Wang B, Kirby PA, Wang K, Ludewig G. 2008. Mutagenicity of 3-methylcholanthrene, pcb3, and 4-oh-pcb3 in the lung of transgenic bigblue rats. Environ Toxicol Pharmacol 25(2):260-266. doi:10.1016/j.etap.2007.10.021 PMID:18438460 PMCID:PMC2346436
• Wang K, You D, Balakrishna S, Ripple M, Ahlert TA, Fahmy B, Becnel D, Daly M, Subra W, McElduff JS, Lomax LG, Troxclair D, Cormier SA. 2008. Sediment from Hurricane Katrina: potential to produce pulmonary dysfunction in mice. Int J Clin Exp Pathol 1:130-144. PMID:19079667